Head and neck cancer Clinical Trials

Recruiting head and neck cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat head and neck cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting head and neck cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting head and neck cancer trials

Within

Maximizing Quality of Life After Cancer Through Rehabilitation

for Head and Neck Cancer

3 sites incl. Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 89

Code: NCT07622407

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07441681·Phase 3

Blood Biomarkers Based Screening for HPV-driven OPC

for Head and Neck Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06528353

SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer

for Oropharyngeal Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07241273

Impact of Chronic MICROplastic Exposure on RADiotherapy of Head and Neck Cancer Patients: Clinical and Translational Oncology Study:

for Head and Neck Cancer

Sponsor: University of Kragujevac

Sex: All·Age: 18+

Code: NCT07690631

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

for Head and Neck Cancer

1 site in Philadelphia

Sponsor: IBA Proton Therapy, Inc.

Sex: All·Age: 18+

Code: NCT07644585

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07659678·Phase 2

Thermotherapy for Head and Neck Cancer Patients

for Head and Neck Cancer

Sponsor: Erasmus Medical Center

Sex: All·Age: 18+

Code: NCT07690618·Phase 1

Sancai Fengsui Decoction for RTOM: A Multicenter RCT

for Radiation-Induced Oral Mucositis (RTOM)

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07692997·Phase 2

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

for Hnscc

1 site in Nashville

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07460765·Phase 1

Apply to this trial

APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Aveta Biomics, Inc.

Sex: All·Age: 18+

Code: NCT07667296·Phase 3

A Phase II Study to Evaluate the Efficacy and Safety of SKB571 in Recurrent or Metastatic HNSCC Participants

for HNSCC

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07668154·Phase 2

Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction

for Head and Neck Cancer

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07694726

Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer

for Head and Neck Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07667400·Phase 1, Phase 2

Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation

for HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07628062·Phase 2

Pucotenlimab Plus Becotatug Vedotin in Perioperative Treatment of Locally Advanced Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Lepu Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT07586124·Phase 2

Apply to this trial

Camrelizumab With Famitinib for Patients With Rare Head and Neck Malignancies

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18+

Code: NCT07662681·Phase 1, Phase 2

Apply to this trial

Efficacy and Safety of Paclitaxel Polymeric Micelles in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07662746·Phase 2

Apply to this trial

Becotatug Vedotin Plus PD-1 Inhibitor for Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Feng Liu

Sex: All·Age: 18 - 80

Code: NCT07683507·Phase 2

Study of a 1-Millimeter Resolution Clinical Positron Emission Tomography (PET) System in Head and Neck Cancer Imaging

for Head and Neck Cancer

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 19+

Code: NCT04662554

Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse

for Head and Neck Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 99

Code: NCT06660017·Phase 2

ABY-029 Head & Neck Trial

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT07279116·Phase 1

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)

for Oral Cavity Squamous Cell Carcinoma

3 sites incl. Atlanta

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07484139·Phase 2

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07552558·Phase 1, Phase 2

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

1 site in Edison

Sponsor: InduPro, Inc.

Sex: All·Age: 18+

Code: NCT07602842·Phase 1, Phase 2

A First-in-Human Study of HH160 in Patients With Advanced Solid Tumors

for Solid Tumor

Sponsor: Huahui Health

Sex: All·Age: 18 - 75

Code: NCT07623369·Phase 1

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

for Head and Neck Disorder

1 site in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT07631650·Phase 2

MRG003 Plus Toripalimab Versus Toripalimab as Neoadjuvant Therapy for PD-L1-Positive, Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dongguan People's Hospital

Sex: All·Age: 18 - 70

Code: NCT07677475·Phase 2

A Study of a New PET Scanner in People With Cancer

for Non Small Cell Lung Carcinoma NSCLC

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07690917

Apply to this trial

Becotatug Vedotin Combined With Pucotenlimab for Locally Recurrent Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07632339·Phase 2

Apply to this trial

Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis

for Radiation-Induced Skin Fibrosis

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07567235·Phase 1

Apply to this trial

A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment

for Head and Neck Cancer

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07179315·Phase 2

Apply to this trial

Staph Nasal Decolonization to Improve Function and Feeding

for Radiation Mucositis

Sponsor: David Palma

Sex: All·Age: 18+

Code: NCT07524894·Phase 2

Effects of Infusion Timing on Treatment Response in Solid Tumors

for Lung Cancer

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07630168·Phase 2

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)

for Head and Neck Cancer

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07418034·Phase 2

Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II Study

for Head and Neck Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT07589049·Phase 2

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

for Ovarian Cancer

Sponsor: Zelluna Immunotherapy AS

Sex: All·Age: 18 - 75

Code: NCT07613723·Phase 1

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Safety, Tolerability, and Preliminary Antitumor Activity of Non-Cationic Peptide-CD47 siRNA in Advanced Solid Tumors

for Solid Tumor Cancer

Sponsor: West China Hospital

Sex: All·Age: 18 - 70

Code: NCT07583914·Phase 1

A Phase 1 First-in-Human Study of CRPA1A2, a MAGE-A1/HLA-A*02:01 Bispecific T-Cell Engager, in Patients With Solid Tumors

for Lung Cancer (Locally Advanced or Metastatic)

Sponsor: Corregene Biotechnology Co., Ltd

Sex: All·Age: 18+

Code: NCT07583316·Phase 1

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

6 sites incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06980038·Phase 2

Apply to this trial

Skin Color Matching in Head and Neck Reconstructive Surgery

for Head and Neck Cancer

3 sites incl. Guilford

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07431099

Apply to this trial

Evolution of Masticatory Function, Orofacial Functions and Quality of Life of Patients Treated for Cancers of the Upper Aerodigestive Tract, Rehabilitated by Maxillofacial Prostheses.

for Head and Neck Cancer

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07471451

Apply to this trial

Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

for Solid Tumor Malignancies

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT07407582·Phase 1, Phase 2

Apply to this trial

CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs

for Head and Neck Squamous Cell Carcinoma

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07172256·Phase 2

Apply to this trial

Postoperative Radiotherapy With Nimotuzumab ± Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18+

Code: NCT07535567·Phase 2, Phase 3

This Protocol Focuses on the Factors That Influence Survival, the Development of Complications and the Quality of Life Based on the Treatment Received in the Group of Patients Suffering From Malignant Lesions of the Head and Neck

for Head and Neck Cancer

Sponsor: IRCCS San Raffaele

Sex: All·Age: 18+

Code: NCT07066878

Prehabilitation Protocol for Head and Neck Cancer Patients

for Head and Neck Cancer

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07318220

Apply to this trial

Neoadjuvant Radio-immunotherapy Versus Immunotherapy Alone for Locally Advanced HNSCC

for Head and Neck Squamous Cell Carcinoma

Sponsor: Chen Chunyan

Sex: All·Age: 18 - 70

Code: NCT07554768·Phase 2

A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions

for Hypopharyngeal Cancer

Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07532538

Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology

for Small Cell Lung Cancer

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+

Code: NCT07550049

Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCC

for Head and Neck Squamous Cell Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18+

Code: NCT07572864·Phase 2

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Proton Versus Photon Therapy in Head and Neck Squamous Cell Carcinomas.

for HNSCC

Sponsor: Oslo University Hospital

Sex: All·Age: 40 - 90

Code: NCT07580300·Phase 3

Apply to this trial

18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors

for Clear Cell Renal Cell Cancer (ccRCC)

Sponsor: Peking University First Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07557225

Apply to this trial

Study Evaluating [18F]NOTA-ABY030 for Safety and Tolerability of Indeterminate Primary and/or Metastatic Disease in Head and Neck Squamous Cell Carcinoma

for SCC - Squamous Cell Carcinoma

1 site in Nashville

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07217028·Phase 1

Apply to this trial

Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Sex: All·Age: 18 - 75

Code: NCT07601737·Phase 2

Apply to this trial

BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy Progression

for Recurrent Head and Neck Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT07618624·Phase 2

Hypofractionated Radiotherapy for Postoperative Intermediate-Risk Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18 - 100

Code: NCT07507058

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

for Epidermal Growth Factor

6 sites incl. Los Angeles

Sponsor: EpiBiologics

Sex: All·Age: 18+

Code: NCT07462377·Phase 1

Apply to this trial

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

for Breast Cancer

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07524114

Apply to this trial

Study of IBI3028 in Participants With Locally Advanced, Unresectable, or Metastatic Solid Tumors

for Solid Tumor

Sponsor: Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD.

Sex: All·Age: 18+

Code: NCT07589205·Phase 1

Apply to this trial

Head and neck cancer clinical trials — common questions

Are head and neck cancer clinical trials free to join?

Yes. Participating in a head and neck cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a head and neck cancer clinical trial?

Each head and neck cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a head and neck cancer trial near me?

Use the location controls above. We'll show recruiting head and neck cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many head and neck cancer trials are recruiting right now?

We're currently tracking roughly 201 recruiting head and neck cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Head and neck cancer trials by city

Boston, MA Duarte, CA Los Angeles, CA Birmingham, AL Chicago, IL La Jolla, CA Miami, FL Stanford, CA Tampa, FL Aurora, CO Beverly Hills, CA Cleveland, OH

Related specialties

Oncology ENT