Head and neck cancer Clinical Trials

Recruiting head and neck cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat head and neck cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting head and neck cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting head and neck cancer trials

Within

Maximizing Quality of Life After Cancer Through Rehabilitation

for Head and Neck Cancer

3 sites incl. Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 89

Code: NCT07622407

A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

for Ovarian Cancer

Sponsor: LG Chem

Sex: All·Age: 18+

Code: NCT07752875·Phase 1, Phase 2

Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry

for Pancreas Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07732686

A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.

for Imaging

Sponsor: Radiopharm Theranostics, Ltd

Sex: All·Age: 18+

Code: NCT07272642·Phase 1

Comparing Radiotherapy Immobilization Systems for Anxious HNC Patients

for Head and Neck Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT06257121

Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)

for Head and Neck Cancer

1 site in Lexington

Sponsor: Mark Bernard

Sex: All·Age: 18 - 99

Code: NCT07770100·Phase 2

Study of a 1-Millimeter Resolution Clinical Positron Emission Tomography (PET) System in Head and Neck Cancer Imaging

for Head and Neck Cancer

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 19+

Code: NCT04662554

Blood Biomarkers Based Screening for HPV-driven OPC

for Head and Neck Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06528353

Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse

for Head and Neck Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 99

Code: NCT06660017·Phase 2

SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer

for Oropharyngeal Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07241273

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)

for Head and Neck Cancer

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07418034·Phase 2

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)

for Oral Cavity Squamous Cell Carcinoma

3 sites incl. Atlanta

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07484139·Phase 2

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07552558·Phase 1, Phase 2

Impact of Chronic MICROplastic Exposure on RADiotherapy of Head and Neck Cancer Patients: Clinical and Translational Oncology Study:

for Head and Neck Cancer

Sponsor: University of Kragujevac

Sex: All·Age: 18+

Code: NCT07690631

Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction

for Head and Neck Cancer

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07694726

Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)

for HNSCC

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07741565·EARLY_Phase 1

A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07744126·Phase 2

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

for Head and Neck Disorder

1 site in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT07631650·Phase 2

Apply to this trial

Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer

for Head and Neck Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07667400·Phase 1, Phase 2

Thermotherapy for Head and Neck Cancer Patients

for Head and Neck Cancer

Sponsor: Erasmus Medical Center

Sex: All·Age: 18+

Code: NCT07690618·Phase 1

Apply to this trial

Neoadjuvant Presurgical Becotatug Vedotin (MRG003) Plus Pucotenlimab (HX008) in Oral Cavity Squamous Cell Carcinoma

for Oral Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 70

Code: NCT07766889·Phase 2

Adebrelimab Combined With Dalpiciclib Isethionate Plus Chemotherapy for Neoadjuvant Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

for HNSCC

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: All·Age: 18+

Code: NCT07778732·Phase 2

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

for Head and Neck Cancer

1 site in Philadelphia

Sponsor: IBA Proton Therapy, Inc.

Sex: All·Age: 18+

Code: NCT07644585

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07659678·Phase 2

RiMO-HNC-NEO1: Phase 2 Study of RiMO-301 and Hypofractionated Radiotherapy With Pembrolizumab for the Neoadjuvant Treatment of Resectable, Locally Advanced Head-Neck Cancer

for Head and Neck Cancer

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07732634·Phase 2

Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma

for HNSCC,Larynx, Pharynx and Oral Cavity

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07741643·Phase 1

A Study of IOV-5001 in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT07743723·Phase 1, Phase 2

To Evaluate the Efficacy and Safety of Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) Combined With NBB-001 and NBB-002 for Patients With Recurrent Head and Neck Malignancies

for Head and Neck Cancer

Sponsor: Neuboron Bio-SciTech Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07795034·Phase 2

Online Sharing for Head & Neck Cancer Support

for Head and Neck Squamous Cell Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07766226

Apply to this trial

SYS6010 vs Investigator's Choice of Monotherapy in Patients With Recurrent or Metastatic HNSCC

for Head and Neck Squamous Cell Carcinoma

Sponsor: CSPC Megalith Biopharmaceutical Co.,Ltd.

Sex: All·Age: 18 - 75

Code: NCT07758621·Phase 3

MRG003 Plus Toripalimab Versus Toripalimab as Neoadjuvant Therapy for PD-L1-Positive, Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dongguan People's Hospital

Sex: All·Age: 18 - 70

Code: NCT07677475·Phase 2

Effects of Infusion Timing on Treatment Response in Solid Tumors

for Lung Cancer

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07630168·Phase 2

Sancai Fengsui Decoction for RTOM: A Multicenter RCT

for Radiation-Induced Oral Mucositis (RTOM)

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07692997·Phase 2

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

63 sites incl. Beverly Hills

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07441681·Phase 3

Apply to this trial

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

for Hnscc

1 site in Nashville

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07460765·Phase 1

Apply to this trial

APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Aveta Biomics, Inc.

Sex: All·Age: 18+

Code: NCT07667296·Phase 3

A Phase II Study to Evaluate the Efficacy and Safety of SKB571 in Recurrent or Metastatic HNSCC Participants

for HNSCC

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07668154·Phase 2

Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation

for HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07628062·Phase 2

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

6 sites incl. Los Angeles

Sponsor: InduPro, Inc.

Sex: All·Age: 18+

Code: NCT07602842·Phase 1, Phase 2

Apply to this trial

Pucotenlimab Plus Becotatug Vedotin in Perioperative Treatment of Locally Advanced Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Lepu Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT07586124·Phase 2

Apply to this trial

Camrelizumab With Famitinib for Patients With Rare Head and Neck Malignancies

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18+

Code: NCT07662681·Phase 1, Phase 2

Apply to this trial

Efficacy and Safety of Paclitaxel Polymeric Micelles in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07662746·Phase 2

Apply to this trial

Becotatug Vedotin Plus PD-1 Inhibitor for Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Feng Liu

Sex: All·Age: 18 - 80

Code: NCT07683507·Phase 2

ABY-029 Head & Neck Trial

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT07279116·Phase 1

A Study of a New PET Scanner in People With Cancer

for Non Small Cell Lung Carcinoma NSCLC

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07690917

Apply to this trial

Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCC

for Head and Neck Squamous Cell Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18+

Code: NCT07572864·Phase 2

Apply to this trial

Becotatug Vedotin Combined With Pucotenlimab for Locally Recurrent Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07632339·Phase 2

Apply to this trial

Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis

for Radiation-Induced Skin Fibrosis

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07567235·Phase 1

Apply to this trial

SGRT in Head and Neck Cancer Radiotherapy

for Head and Neck Cancer

Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Sex: All·Age: 18 - 75

Code: NCT07726407

Apply to this trial

A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

Sponsor: Huahui Health

Sex: All·Age: 18 - 75

Code: NCT07623369·Phase 1

Apply to this trial

A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment

for Head and Neck Cancer

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07179315·Phase 2

Apply to this trial

Staph Nasal Decolonization to Improve Function and Feeding

for Radiation Mucositis

Sponsor: David Palma

Sex: All·Age: 18+

Code: NCT07524894·Phase 2

Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II Study

for Head and Neck Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT07589049·Phase 2

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

for Ovarian Cancer

Sponsor: Zelluna Immunotherapy AS

Sex: All·Age: 18 - 75

Code: NCT07613723·Phase 1

Apply to this trial

Safety, Tolerability, and Preliminary Antitumor Activity of Non-Cationic Peptide-CD47 siRNA in Advanced Solid Tumors

for Solid Tumor Cancer

Sponsor: West China Hospital

Sex: All·Age: 18 - 70

Code: NCT07583914·Phase 1

A Phase 1 First-in-Human Study of CRPA1A2, a MAGE-A1/HLA-A*02:01 Bispecific T-Cell Engager, in Patients With Solid Tumors

for Lung Cancer (Locally Advanced or Metastatic)

Sponsor: Corregene Biotechnology Co., Ltd

Sex: All·Age: 18+

Code: NCT07583316·Phase 1

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

10 sites incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06980038·Phase 2

Apply to this trial

Skin Color Matching in Head and Neck Reconstructive Surgery

for Head and Neck Cancer

3 sites incl. Guilford

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07431099

Apply to this trial

Evolution of Masticatory Function, Orofacial Functions and Quality of Life of Patients Treated for Cancers of the Upper Aerodigestive Tract, Rehabilitated by Maxillofacial Prostheses.

for Head and Neck Cancer

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07471451

Apply to this trial

Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

for Solid Tumor Malignancies

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT07407582·Phase 1, Phase 2

Apply to this trial

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Head and neck cancer clinical trials — common questions

Are head and neck cancer clinical trials free to join?

Yes. Participating in a head and neck cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a head and neck cancer clinical trial?

Each head and neck cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a head and neck cancer trial near me?

Use the location controls above. We'll show recruiting head and neck cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many head and neck cancer trials are recruiting right now?

We're currently tracking roughly 201 recruiting head and neck cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Head and neck cancer trials by city

Duarte, CA Boston, MA Los Angeles, CA Chicago, IL Beverly Hills, CA Birmingham, AL La Jolla, CA Miami, FL Stanford, CA Tampa, FL Aurora, CO Cleveland, OH

Related specialties

Oncology ENT