ENT Clinical Trials

Recruiting ent studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat ent. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting ent studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting ent trials

Within

AI-Enabled Mobile App for Safe Eating in Older Adults With Dysphagia

for Deglutition Disorders

Sponsor: KAM Chi Shan Anna

Sex: All·Age: 60+

Code: NCT07654088

Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial

for Dysphagia

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07736105

From Early Music Audiometry to Tone Audiograms

for Hearing Loss

Sponsor: Guy's and St Thomas' NHS Foundation Trust

Sex: All·Age: 7 - 45

Code: NCT07722936

Maximizing Quality of Life After Cancer Through Rehabilitation

for Head and Neck Cancer

3 sites incl. Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 89

Code: NCT07622407

Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures

for Cough

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06579989

Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD

for Dysphagia

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT07773025

SPI-1005 in Adults Receiving Cochlear Implant

for Hearing Loss

6 sites incl. Iowa City

Sponsor: Sound Pharmaceuticals, Incorporated

Sex: All·Age: 18+

Code: NCT06340633·Phase 2

Apply to this trial

A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

for Ovarian Cancer

Sponsor: LG Chem

Sex: All·Age: 18+

Code: NCT07752875·Phase 1, Phase 2

HEARS Maryland: Extending Capacity for Affordable, Accessible Hearing Care Through Older Adult Peer Mentorship

for Hearing Loss

Sponsor: Johns Hopkins University

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07699146

Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry

for Pancreas Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07732686

A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.

for Imaging

Sponsor: Radiopharm Theranostics, Ltd

Sex: All·Age: 18+

Code: NCT07272642·Phase 1

Comparing Radiotherapy Immobilization Systems for Anxious HNC Patients

for Head and Neck Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT06257121

Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)

for Head and Neck Cancer

1 site in Lexington

Sponsor: Mark Bernard

Sex: All·Age: 18 - 99

Code: NCT07770100·Phase 2

Study of a 1-Millimeter Resolution Clinical Positron Emission Tomography (PET) System in Head and Neck Cancer Imaging

for Head and Neck Cancer

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 19+

Code: NCT04662554

Blood Biomarkers Based Screening for HPV-driven OPC

for Head and Neck Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06528353

Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse

for Head and Neck Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 99

Code: NCT06660017·Phase 2

SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer

for Oropharyngeal Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07241273

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)

for Head and Neck Cancer

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07418034·Phase 2

Standardizing Swallow Pressure Measurements

for Dysphagia

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07475091

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)

for Oral Cavity Squamous Cell Carcinoma

3 sites incl. Atlanta

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07484139·Phase 2

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07552558·Phase 1, Phase 2

Impact of Chronic MICROplastic Exposure on RADiotherapy of Head and Neck Cancer Patients: Clinical and Translational Oncology Study:

for Head and Neck Cancer

Sponsor: University of Kragujevac

Sex: All·Age: 18+

Code: NCT07690631

Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction

for Head and Neck Cancer

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07694726

Benefit of a Clinically Streamlined and Structured Aural Rehabilitation (CSSAR) Program in Adults

for Hearing Loss

1 site in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 55+

Code: NCT07719114

Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)

for HNSCC

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07741565·EARLY_Phase 1

A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07744126·Phase 2

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

for Head and Neck Disorder

1 site in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT07631650·Phase 2

Apply to this trial

The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

for Dysphagia

1 site in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT07027826

Apply to this trial

Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer

for Head and Neck Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07667400·Phase 1, Phase 2

Neoadjuvant Presurgical Becotatug Vedotin (MRG003) Plus Pucotenlimab (HX008) in Oral Cavity Squamous Cell Carcinoma

for Oral Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 70

Code: NCT07766889·Phase 2

Adebrelimab Combined With Dalpiciclib Isethionate Plus Chemotherapy for Neoadjuvant Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

for HNSCC

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: All·Age: 18+

Code: NCT07778732·Phase 2

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

for Head and Neck Cancer

1 site in Philadelphia

Sponsor: IBA Proton Therapy, Inc.

Sex: All·Age: 18+

Code: NCT07644585

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07659678·Phase 2

RiMO-HNC-NEO1: Phase 2 Study of RiMO-301 and Hypofractionated Radiotherapy With Pembrolizumab for the Neoadjuvant Treatment of Resectable, Locally Advanced Head-Neck Cancer

for Head and Neck Cancer

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07732634·Phase 2

Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma

for HNSCC,Larynx, Pharynx and Oral Cavity

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07741643·Phase 1

A Study of IOV-5001 in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT07743723·Phase 1, Phase 2

AI-Based Dysphagia Rehabilitation Program: Development and Validation

for Dysphagia

Sponsor: National Research Center for Rehabilitation Technical Aids

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07767123

To Evaluate the Efficacy and Safety of Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) Combined With NBB-001 and NBB-002 for Patients With Recurrent Head and Neck Malignancies

for Head and Neck Cancer

Sponsor: Neuboron Bio-SciTech Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07795034·Phase 2

SYS6010 vs Investigator's Choice of Monotherapy in Patients With Recurrent or Metastatic HNSCC

for Head and Neck Squamous Cell Carcinoma

Sponsor: CSPC Megalith Biopharmaceutical Co.,Ltd.

Sex: All·Age: 18 - 75

Code: NCT07758621·Phase 3

MRG003 Plus Toripalimab Versus Toripalimab as Neoadjuvant Therapy for PD-L1-Positive, Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dongguan People's Hospital

Sex: All·Age: 18 - 70

Code: NCT07677475·Phase 2

Effects of Infusion Timing on Treatment Response in Solid Tumors

for Lung Cancer

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07630168·Phase 2

Thermotherapy for Head and Neck Cancer Patients

for Head and Neck Cancer

Sponsor: Erasmus Medical Center

Sex: All·Age: 18+

Code: NCT07690618·Phase 1

Sancai Fengsui Decoction for RTOM: A Multicenter RCT

for Radiation-Induced Oral Mucositis (RTOM)

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07692997·Phase 2

Online Sharing for Head & Neck Cancer Support

for Head and Neck Squamous Cell Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07766226

Mechanisms of Air-pulse Pharyngeal Sensory Stimulation Regulation Post-stroke Swallowing Neural Network Remodeling Via TRPV4 Channel

for Dysphagia

Sponsor: First People's Hospital of Foshan

Sex: All·Age: 18 - 76·Accepts healthy volunteers

Code: NCT07782424

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

63 sites incl. Beverly Hills

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07441681·Phase 3

Apply to this trial

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

for Hnscc

1 site in Nashville

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07460765·Phase 1

Apply to this trial

APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Aveta Biomics, Inc.

Sex: All·Age: 18+

Code: NCT07667296·Phase 3

A Phase II Study to Evaluate the Efficacy and Safety of SKB571 in Recurrent or Metastatic HNSCC Participants

for HNSCC

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07668154·Phase 2

Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions

for Dysphagia

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 5 - 21

Code: NCT07780981

Apply to this trial

Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation

for HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07628062·Phase 2

Comparison of Sedated and Unsedated PEG in Elderly ASA IV Patients

for Percutaneous Endoscopic Gastrostomy

Sponsor: Mersin University

Sex: All·Age: 65+

Code: NCT07758153

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

7 sites incl. Los Angeles

Sponsor: InduPro, Inc.

Sex: All·Age: 18+

Code: NCT07602842·Phase 1, Phase 2

Apply to this trial

Pucotenlimab Plus Becotatug Vedotin in Perioperative Treatment of Locally Advanced Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Lepu Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT07586124·Phase 2

Apply to this trial

WhatsApp AI Support vs Paper Support for First-Time Hearing Aid Users

for Hearing Loss

Sponsor: University of Pretoria

Sex: All·Age: 18+

Code: NCT07690670

Apply to this trial

Survey of Sensory Impairment Indicators Among Adults Aged 65 Years and Older in Xinxing County

for Visual Impairment

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07694505

Self-monitoring of Hearing Aids Using Artificial Intelligence

for Hearing Loss

Sponsor: Sodra Alvsborgs Hospital

Sex: All·Age: 18+

Code: NCT07255586

Camrelizumab With Famitinib for Patients With Rare Head and Neck Malignancies

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18+

Code: NCT07662681·Phase 1, Phase 2

Apply to this trial

Efficacy and Safety of Paclitaxel Polymeric Micelles in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07662746·Phase 2

Apply to this trial

Becotatug Vedotin Plus PD-1 Inhibitor for Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Feng Liu

Sex: All·Age: 18 - 80

Code: NCT07683507·Phase 2

New trials in Boston, MA?

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ENT clinical trials — common questions

Are ent clinical trials free to join?

Yes. Participating in a ent clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a ent clinical trial?

Each ent study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a ent trial near me?

Use the location controls above. We'll show recruiting ent trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many ent trials are recruiting right now?

We're currently tracking roughly 274 recruiting ent trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

ENT trials by city

Boston, MA Duarte, CA Los Angeles, CA Aurora, CO Chicago, IL Miami, FL Stanford, CA Beverly Hills, CA Birmingham, AL Cleveland, OH La Jolla, CA Tampa, FL

Conditions in this area

Hearing loss Dysphagia Head and neck cancer