ENT Clinical Trials

Recruiting ent studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat ent. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting ent studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting ent trials

Within

AI-Enabled Mobile App for Safe Eating in Older Adults With Dysphagia

for Deglutition Disorders

Sponsor: KAM Chi Shan Anna

Sex: All·Age: 60+

Code: NCT07654088

Maximizing Quality of Life After Cancer Through Rehabilitation

for Head and Neck Cancer

3 sites incl. Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 89

Code: NCT07622407

Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures

for Cough

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06579989

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07441681·Phase 3

SPI-1005 in Adults Receiving Cochlear Implant

for Hearing Loss

6 sites incl. Iowa City

Sponsor: Sound Pharmaceuticals, Incorporated

Sex: All·Age: 18+

Code: NCT06340633·Phase 2

Apply to this trial

HEARS Maryland: Extending Capacity for Affordable, Accessible Hearing Care Through Older Adult Peer Mentorship

for Hearing Loss

Sponsor: Johns Hopkins University

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07699146

Blood Biomarkers Based Screening for HPV-driven OPC

for Head and Neck Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06528353

SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer

for Oropharyngeal Squamous Cell Carcinoma

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07241273

Impact of Chronic MICROplastic Exposure on RADiotherapy of Head and Neck Cancer Patients: Clinical and Translational Oncology Study:

for Head and Neck Cancer

Sponsor: University of Kragujevac

Sex: All·Age: 18+

Code: NCT07690631

Benefit of a Clinically Streamlined and Structured Aural Rehabilitation (CSSAR) Program in Adults

for Hearing Loss

1 site in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 55+

Code: NCT07719114

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

for Head and Neck Cancer

1 site in Philadelphia

Sponsor: IBA Proton Therapy, Inc.

Sex: All·Age: 18+

Code: NCT07644585

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07659678·Phase 2

Thermotherapy for Head and Neck Cancer Patients

for Head and Neck Cancer

Sponsor: Erasmus Medical Center

Sex: All·Age: 18+

Code: NCT07690618·Phase 1

Sancai Fengsui Decoction for RTOM: A Multicenter RCT

for Radiation-Induced Oral Mucositis (RTOM)

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07692997·Phase 2

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

for Hnscc

1 site in Nashville

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT07460765·Phase 1

Apply to this trial

Standardizing Swallow Pressure Measurements

for Dysphagia

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07475091

APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Aveta Biomics, Inc.

Sex: All·Age: 18+

Code: NCT07667296·Phase 3

A Phase II Study to Evaluate the Efficacy and Safety of SKB571 in Recurrent or Metastatic HNSCC Participants

for HNSCC

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07668154·Phase 2

Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction

for Head and Neck Cancer

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07694726

The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

for Dysphagia

1 site in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT07027826

Apply to this trial

Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer

for Head and Neck Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07667400·Phase 1, Phase 2

Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation

for HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07628062·Phase 2

Pucotenlimab Plus Becotatug Vedotin in Perioperative Treatment of Locally Advanced Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Lepu Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT07586124·Phase 2

Apply to this trial

WhatsApp AI Support vs Paper Support for First-Time Hearing Aid Users

for Hearing Loss

Sponsor: University of Pretoria

Sex: All·Age: 18+

Code: NCT07690670

Apply to this trial

Survey of Sensory Impairment Indicators Among Adults Aged 65 Years and Older in Xinxing County

for Visual Impairment

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07694505

Self-monitoring of Hearing Aids Using Artificial Intelligence

for Hearing Loss

Sponsor: Sodra Alvsborgs Hospital

Sex: All·Age: 18+

Code: NCT07255586

Camrelizumab With Famitinib for Patients With Rare Head and Neck Malignancies

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18+

Code: NCT07662681·Phase 1, Phase 2

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Efficacy and Safety of Paclitaxel Polymeric Micelles in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07662746·Phase 2

Apply to this trial

Becotatug Vedotin Plus PD-1 Inhibitor for Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Feng Liu

Sex: All·Age: 18 - 80

Code: NCT07683507·Phase 2

Treatment of Dysphagia in Patients With Dystrophic Epidermolysis Bullosa With Budesonide: a Retrospective Bicentric Study Nice - Paris St Louis / Necker (EBUDE Study)

for Recessive Dystrophic Epidermolysis Bullosa

Sponsor: Centre Hospitalier Universitaire de Nice

Sex: All·Age: 1+

Code: NCT07684105

Study of a 1-Millimeter Resolution Clinical Positron Emission Tomography (PET) System in Head and Neck Cancer Imaging

for Head and Neck Cancer

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 19+

Code: NCT04662554

Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse

for Head and Neck Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 99

Code: NCT06660017·Phase 2

ABY-029 Head & Neck Trial

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT07279116·Phase 1

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)

for Oral Cavity Squamous Cell Carcinoma

3 sites incl. Atlanta

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07484139·Phase 2

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07552558·Phase 1, Phase 2

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

1 site in Edison

Sponsor: InduPro, Inc.

Sex: All·Age: 18+

Code: NCT07602842·Phase 1, Phase 2

Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS

for Amyotrophic Lateral Sclerosis (ALS)

Sponsor: Nova Southeastern University

Sex: All·Age: 18 - 90

Code: NCT07606235

Biomechanical Effects of EMST® on Swallowing Function in Parkinson's Disease

for Parkinson's Disease (PD)

Sponsor: University Hospital Muenster

Sex: All·Age: 18+

Code: NCT07606547

Apply to this trial

A First-in-Human Study of HH160 in Patients With Advanced Solid Tumors

for Solid Tumor

Sponsor: Huahui Health

Sex: All·Age: 18 - 75

Code: NCT07623369·Phase 1

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

for Head and Neck Disorder

1 site in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT07631650·Phase 2

MRG003 Plus Toripalimab Versus Toripalimab as Neoadjuvant Therapy for PD-L1-Positive, Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma

Sponsor: Dongguan People's Hospital

Sex: All·Age: 18 - 70

Code: NCT07677475·Phase 2

A Study of a New PET Scanner in People With Cancer

for Non Small Cell Lung Carcinoma NSCLC

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07690917

Apply to this trial

Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders

for Malnutrition

Sponsor: University Psychiatric Clinic Ljubljana

Sex: All·Age: 65+

Code: NCT07710456

Efficacy and Mechanism of 'Yanjiu Needle' for Pharyngeal Dysphagia Based on sEMG Features

for Acupuncture

Sponsor: The Third People's Hospital of Huizhou

Sex: All·Age: 40 - 75

Code: NCT07656025

Becotatug Vedotin Combined With Pucotenlimab for Locally Recurrent Resectable Head and Neck Squamous Cell Carcinoma

for Head and Neck Cancer

Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Sex: All·Age: 18 - 75

Code: NCT07632339·Phase 2

Apply to this trial

Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis

for Radiation-Induced Skin Fibrosis

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07567235·Phase 1

Apply to this trial

DDK Acoustic Analysis and Swallowing Indicators

for Swallowing Function

Sponsor: Kaohsiung Medical University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07626749

A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment

for Head and Neck Cancer

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07179315·Phase 2

Apply to this trial

Effect of an Oral Neuromuscular Training Device on Dysphagia

for Dysphagia

Sponsor: University of Aarhus

Sex: All·Age: 18+

Code: NCT07451028

Apply to this trial

Staph Nasal Decolonization to Improve Function and Feeding

for Radiation Mucositis

Sponsor: David Palma

Sex: All·Age: 18+

Code: NCT07524894·Phase 2

Effects of Infusion Timing on Treatment Response in Solid Tumors

for Lung Cancer

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07630168·Phase 2

Same-Day Cochlear Implant Activation (SDA-CI)

for Hearing Loss

Sponsor: University of Aarhus

Sex: All·Age: 18+

Code: NCT07681830

A Study to Evaluate Clinical Benefit, Performance and Safety of Cochlear Implants in Adults

for Hearing Loss

Sponsor: Cochlear

Sex: All·Age: 18+

Code: NCT07338864

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)

for Head and Neck Cancer

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07418034·Phase 2

System-integrated Technology-enabled Model of Care to Improve the Health of Stroke Patients With Dysphagia

for Dysphagia

Sponsor: Zeng Xi

Sex: All·Age: 18+

Code: NCT07563465

Hearing Outcomes With the Nucleus® 8 Sound Processor and Nucleus® 7 Sound Processor in Adult Veteran and Non-veteran Cochlear Implant Recipients

for Hearing Loss

1 site in Lone Tree

Sponsor: Cochlear

Sex: All·Age: 18+

Code: NCT07582198

Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II Study

for Head and Neck Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT07589049·Phase 2

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

for Ovarian Cancer

Sponsor: Zelluna Immunotherapy AS

Sex: All·Age: 18 - 75

Code: NCT07613723·Phase 1

Apply to this trial

Safety, Tolerability, and Preliminary Antitumor Activity of Non-Cationic Peptide-CD47 siRNA in Advanced Solid Tumors

for Solid Tumor Cancer

Sponsor: West China Hospital

Sex: All·Age: 18 - 70

Code: NCT07583914·Phase 1

A Phase 1 First-in-Human Study of CRPA1A2, a MAGE-A1/HLA-A*02:01 Bispecific T-Cell Engager, in Patients With Solid Tumors

for Lung Cancer (Locally Advanced or Metastatic)

Sponsor: Corregene Biotechnology Co., Ltd

Sex: All·Age: 18+

Code: NCT07583316·Phase 1

ENT clinical trials — common questions

Are ent clinical trials free to join?

Yes. Participating in a ent clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a ent clinical trial?

Each ent study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a ent trial near me?

Use the location controls above. We'll show recruiting ent trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many ent trials are recruiting right now?

We're currently tracking roughly 274 recruiting ent trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

ENT trials by city

Boston, MA Duarte, CA Los Angeles, CA Aurora, CO Miami, FL Stanford, CA Chicago, IL Birmingham, AL Cleveland, OH La Jolla, CA San Francisco, CA Tampa, FL

Conditions in this area

Hearing loss Dysphagia Head and neck cancer