Effects of Stimulant Medications in PTSD

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT07664631
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    dextrose
  • Adderall — DRUG
    mixed amphetamine salts

Study Details

While there have been advances in understanding post-traumatic stress disorder (PTSD) as a disorder and its biological features, unfortunately only one out of five traumatized persons with PTSD reach remission after cycling through evidence-based and/or FDA-approved medications. This is especially unfortunate given that people with PTSD are often from vulnerable populations, or those whose professions entail personal sacrifice. It is clear that new serotonergic antidepressants and atypical antipsychotics will not be sufficient to fix this gap, and new mechanisms of action need to be tested. In the current proposal, the investigators test the hypothesis that mixed amphetamine salts (brand name Adderall), FDA-approved for treating attention deficit hyperactivity disorder (ADHD), can improve PTSD outcomes.

Key Dates

Start date
Sep 15, 2026
Status verified
Jun 2026
Primary completion
Sep 15, 2027
Completion
Sep 15, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: placebo
    dextrose
  • Experimental: Adderall
    Adderall (20 mg)

Primary Outcome Measure

Quality of Social Interaction Ratings using the Conversation Questionnaire [ Time Frame: Completed 4 hours post-drug administration during both sessions (drug, placebo) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of ChicagoChicagoIllinois60637
Hanna Molla
[email protected]
7737023560
Royce Lee (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chicago, IL

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
University of Chicago· Chicago, IL

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