Radiation Therapy and Thymus Function in Young Women With Breast Cancer

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT07725172
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Blood draw for the laboratory assessment — PROCEDURE
    Blood will be drawn and processed for Peripheral Blood Mononuclear Cells (PBMCs). PBMC biomarkers will be used to assess thymopoiesis .

Study Details

Breast cancer treatment sometimes includes radiation to the breast or chest wall. There is a small gland, called the thymus, located in the upper chest that may receive a small amount of the radiation aimed at the breast. The goal of this study is to collect blood samples from young women with breast cancer to study the effect of radiation therapy on the thymus gland.

Key Dates

First listed
Jul 24, 2026
Start date
Sep 30, 2026
Status verified
Jul 2026
Primary completion
Sep 30, 2029
Completion
Sep 30, 2029

Study Design

Enrollment
125 participants (estimated)

Arms

  • Arm: Radiation Therapy
    Up to 100 Breast cancer patients receiving radiation therapy
  • Arm: No Radiation Therapy
    Up to 25 Breast cancer patients NOT receiving radiation therapy as control

Primary Outcome Measure

Level of signal joint T cell Receptor Exclusion Circles (sjTREC) in peripheral blood T cells [ Time Frame: baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke Cancer CenterDurhamNorth Carolina27710
Eileen Duffy, RN OCN
[email protected]
919-668-3726
Linda Kaltenbach, PhD
[email protected]
(919) 668-3726
Susan McDuff, MD PhD (PRINCIPAL_INVESTIGATOR)
Andrew Macintyre, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Durham, NC

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By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Duke Cancer Center· Durham, NC

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