Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Novo Nordisk A/S
Study ID
NCT07770841
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Semaglutide — DRUG
    Participants will receive semaglutide orally.
  • Placebo — DRUG
    Participants will receive placebo orally.

Study Details

The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo). Results from this study will help select the most optimal lower dose of oral semaglutide that can be used for treating participants living with overweight or obesity.

Key Dates

First listed
Aug 18, 2026
Start date
Aug 12, 2026
Status verified
Aug 2026
Primary completion
Feb 22, 2028
Completion
Apr 11, 2028

Study Design

Enrollment
450 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Semaglutide
    Participants will receive two different oral doses of semaglutide as an adjunct to a reduced-calorie diet and increased physical activity.
  • Placebo Comparator: Placebo
    Participants will receive oral dose of placebo as an adjunct to a reduced-calorie diet and increased physical activity.

Primary Outcome Measure

Relative change in body weight [ Time Frame: From baseline (week 0) to week 60 ]

Central Contacts

Locations (16)

FacilityCityStateZIPSite coordinators
Uni of Alabama at BirminghamBirminghamAlabama35296-
Headlands Research California, LLCEscondidoCalifornia92025-
National Research Institute - Huntington ParkHuntington ParkCalifornia90255-
Los Angeles Institute for Metabolic ResearchLos AngelesCalifornia90015-
ERG Holding Company, LLC / Evolution Research Group, LLCDelray BeachFlorida33445-
ERG Holding Company, LLC / Evolution Research Group, LLCFort MyersFlorida33192-
Jedidiah Clinical ResearchTampaFlorida33619-
East West Med Res InstHonoluluHawaii96814-
L-MARC Research CenterLouisvilleKentucky40213-
StudyMetrix Research LLCCity of Saint PetersMissouri63303-
Jubilee Clinical Research, Inc.Las VegasNevada89106-
Corvallis Clinic PC Clinical Research DepartmentCorvallisOregon97330-3737-
UPA Ctr Weight and Eating DisPhiladelphiaPennsylvania19104-
Spartanburg Medical ResearchSpartanburgSouth Carolina29303-
Cedar Health ResearchDallasTexas75251-
Selma Medical AssociatesWinchesterVirginia22601-3834-

Find similar trials in Birmingham, AL

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By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Uni of Alabama at Birmingham· Birmingham, ALHeadlands Research California, LLC· Escondido, CANational Research Institute - Huntington Park· Huntington Park, CALos Angeles Institute for Metabolic Research· Los Angeles, CAERG Holding Company, LLC / Evolution Research Group, LLC· Delray Beach, FLERG Holding Company, LLC / Evolution Research Group, LLC· Fort Myers, FL

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