State Representation in Early Psychosis 2

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT07834203
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
15 Years - 45 Years
Healthy Volunteers
Accepted

Study Details

This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and healthy control participants. Participants will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments. The study will evaluate performance and computed parameters from the Translational Orientation Pattern Expectancy task and Translational Bandit Task, along with EEG variables related to cognitive control, reward processing, and neural synchrony. The study aims to better understand heterogeneity in early psychosis and identify neurocognitive and neurophysiologic markers that may inform future precision psychiatry approaches.

Key Dates

First listed
Sep 22, 2026
Start date
Oct 15, 2025
Status verified
Sep 2026
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Early Psychosis Participants
    Participants with a clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis. Participants will complete clinical interviews, self-report measures, cognitive/computerized tasks, and EEG assessments.
  • Arm: Healthy Control Participants
    Community control participants without psychotic or bipolar disorder and without a first-degree family history of psychotic or bipolar disorder. Participants will complete clinical interviews, self-report measures, cognitive/computerized tasks, and EEG assessments.

Primary Outcome Measure

Combined TOPX and TBT State Representation Parameter Score [ Time Frame: Baseline study assessment, up to 8 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of Minnesota Ambulatory Research CenterMinneapolisMinnesota55455
Grace Owens
[email protected]
612-741-2826
Scott Sponheim, PhD, LP (PRINCIPAL_INVESTIGATOR)
University of Minnesota Department of PsychologyMinneapolisMinnesota55455
Grace Owens
[email protected]
612-741-2826
Scott Sponheim, PhD, LP (PRINCIPAL_INVESTIGATOR)

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University of Minnesota Ambulatory Research Center· Minneapolis, MNUniversity of Minnesota Department of Psychology· Minneapolis, MN

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