A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Pfizer
Study ID
NCT07845500
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Semaglutide — DRUG
    Participants will receive Semaglutide administered subcutaneously.
  • Berobenatide — DRUG
    Participants will receive berobenatide solution for injection as subcutaneous injection.
  • Tirzepatide — DRUG
    Participants will receive Tirzepatide administered subcutaneously.

Study Details

The purpose of this study is to learn about the safety and effectiveness of berobenatide in adults with overweight or obesity who have already lost weight while taking semaglutide or tirzepatide. The study does not include people with diabetes. Participants will be in the study for about 11 months.

Key Dates

First listed
Sep 29, 2026
Start date
Sep 30, 2026
Status verified
Oct 2026
Primary completion
Feb 16, 2028
Completion
Feb 16, 2028

Study Design

Enrollment
660 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Active Comparator
    Participants will receive Semaglutide or Tirzepatide by Subcutaneous Injection.
  • Experimental: Experimental
    Participants will receive Berobenatide by Subcutaneous Injection.

Primary Outcome Measure

Percent change from baseline in body weight [ Time Frame: Baseline, Week 32 ]

Central Contacts

Locations (16)

FacilityCityStateZIPSite coordinators
University of Alabama at BirminghamBirminghamAlabama35294-
Velocity Clinical Research - Los AngelesLos AngelesCalifornia90017-
Southern California Clinical ResearchSanta AnaCalifornia92701-
Diablo Clinical Research, LLC dba Flourish ResearchWalnut CreekCalifornia94598-
Jacksonville Center for Clinical ResearchJacksonvilleFlorida32216-
Suncoast Clinical ResearchNew Port RicheyFlorida34652-
Oviedo Medical ResearchOviedoFlorida32765-
Monroe Biomedical ResearchLouisvilleKentucky40213-
Aa Mrc LlcFlintMichigan48504-
SKY Integrative Medical Center/SKYCRNGRidgelandMississippi39157-
Clinical Research ProfessionalsChesterfieldMissouri63005-
Mercury Street Medical Group, PLLCButteMontana59701-
Monroe Biomedical ResearchMonroeNorth Carolina28112-
Accellacare - WilmingtonWilmingtonNorth Carolina28401-
Velocity Clinical Research, Mt. AuburnCincinnatiOhio45219-
Tribe Clinical Research, LLCGreenvilleSouth Carolina29607-

Find similar trials in Birmingham, AL

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By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Alabama at Birmingham· Birmingham, ALVelocity Clinical Research - Los Angeles· Los Angeles, CASouthern California Clinical Research· Santa Ana, CADiablo Clinical Research, LLC dba Flourish Research· Walnut Creek, CAJacksonville Center for Clinical Research· Jacksonville, FLSuncoast Clinical Research· New Port Richey, FL

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