Headache Clinical Trials

Recruiting headache studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat headache. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting headache studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting headache trials

Within

Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial

for Migraine

1 site in Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06170281

Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean Section

for Intravenous Lidocaine

Sponsor: Tanta University

Sex: Female·Age: 18+

Code: NCT07661758·Phase 3

Apply to this trial

Muscle Position and Dry Needling Efficacy

for Neck Pain

Sponsor: University of Alcala

Sex: All·Age: 18 - 80

Code: NCT07629141

Apply to this trial

Utilization of 60-Day Peripheral Nerve Stimulation of the Occipital Nerves for the Treatment of Headache

for Headache

2 sites incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07553533

Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment

for Refractory Migraine

1 site in Camden

Sponsor: Daniel A Tonetti, MD

Sex: All·Age: 18+

Code: NCT07361549·Phase 2

Machine Learning in Guiding rTMS Treatment for GWI-Related Headaches and Body Pain

for Gulf War Illness

1 site in San Diego

Sponsor: Veterans Medical Research Foundation

Sex: All·Age: 18 - 65

Code: NCT07325513

Apply to this trial

Treatment Response in Patients With Medication-Overuse Headache

for Medication-overuse Headache

Sponsor: Sultan 1. Murat State Hospital

Sex: All·Age: 18 - 65

Code: NCT07487649

Apply to this trial

Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine

for Migraine

Sponsor: University of Sao Paulo

Sex: Female·Age: 18 - 48

Code: NCT06716489

Apply to this trial

Filter Lenses for the Prevention of Migraine Attacks

for Migraine

Sponsor: Rune Skovgaard Rasmussen

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06161129

Amylin-Induced Migraine Attacks Without Aura

for Headache Disorders, Primary

Sponsor: Danish Headache Center

Sex: All·Age: 18 - 65

Code: NCT07340788

Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage

for Subarachnoid Hemorrhage, Aneurysmal

1 site in Galveston

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 18 - 100

Code: NCT07294118·Phase 2

Apply to this trial

App-based Breathing Program for Migraine Relief

for Migraine

1 site in Phoenix

Sponsor: Arizona State University

Sex: All·Age: 18+

Code: NCT07297901

Concussion Recovery and Support Program

for Brain Concussion

2 sites in Seattle

Sponsor: Seattle Children's Hospital

Sex: All·Age: 18 - 29

Code: NCT07097792

Apply to this trial

Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Postoperative Headache Following Stent-Assisted Coiling of Unruptured Intracranial Aneurysms

for Unruptured Intracranial Aneurysm

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 18 - 80

Code: NCT07479082

Apply to this trial

Turkish Version of the Headache Screening Questionnaire

for Migraine

Sponsor: Başakşehir Çam & Sakura City Hospital

Sex: All·Age: 18+

Code: NCT07048132

Effects of Photobiomodulation With Superpulsed Laser and Dual Wavelengths in Children and Adolescents

for Facial Pain

Sponsor: University of Nove de Julho

Sex: All·Age: 6 - 17

Code: NCT07031505

0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment

for Headache

1 site in Gainesville

Sponsor: HCA Florida North Florida Hospital

Sex: All·Age: 18+

Code: NCT06937385·Phase 3

Placebo Impacts Sleep and Pain Modulation in Chronic Pain

for Chronic Pain

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 88

Code: NCT06225817

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Can a Specific OMT Protocol Influence Patient Pain and Associated Analgesia Use for Primary Headache Disorders?

for Headache Disorders

1 site in Old Westbury

Sponsor: New York Institute of Technology

Sex: All·Age: 18 - 75

Code: NCT06546462

The Effectiveness of CBD and CBN in the Treatment of Facial Pain and Headache of Muscular Origin

for Myalgia

Sponsor: Wroclaw Medical University

Sex: All·Age: 18+

Code: NCT05961501·Phase 2, Phase 3

Effect of Parcetamol in Headach

for Headache

Sponsor: Assiut University

Sex: All·Age: 18 - 65

Code: NCT06861738·Phase 3

Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches

for Subarachnoid

1 site in Wichita

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+

Code: NCT06582810

Apply to this trial

The BETY-Biopsychosocial Questionnaire (BETY-BQ) in Individuals With Temporomandibular Dysfunction-Related Headache

for Temporomandibular Disorders

Sponsor: Hasan Kalyoncu University

Sex: All·Age: 18 - 60

Code: NCT05902026

Puberty, Testosterone, and Brain Development

for Gender Identity

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 20

Code: NCT06670053

Apply to this trial

Postdural Puncture Headache After Spinal Anesthesia for Cesarean Section

for Headache

Sponsor: Assiut University

Sex: Female·Age: 20 - 45

Code: NCT06683807

External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

for Pregnancy

1 site in Darien

Sponsor: Cefaly Technology

Sex: Female·Age: 18 - 44

Code: NCT06788977

Apply to this trial

Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache

for SAH (Subarachnoid Hemorrhage)

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18 - 100

Code: NCT06621329·Phase 2, Phase 3

Apply to this trial

THE EFFECT OF SURGICAL MASK AND N95 MASK USE ON SURGICAL SMOKE IN OPERATING ROOM NURSES

for Surgical Smoke Exposure

Sponsor: Bartın Unıversity

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07404956

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Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage

for Aneurysmal Subarachnoid Hemorrhage (aSAH)

1 site in Dayton

Sponsor: Wright State University

Sex: All·Age: 18+

Code: NCT07116408·Phase 4

Apply to this trial

The Effect of Osteopathic Treatment on Craniocervico-Mandibular Dysfunction

for Headache

1 site in Auburn

Sponsor: Edward Via Virginia College of Osteopathic Medicine

Sex: All·Age: 19 - 65

Code: NCT06471426

Apply to this trial

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

for Post-Concussion Syndrome

1 site in Westwood, Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT06073886·Phase 2

Apply to this trial

Headache Registration and Followup Initiated by Tongji Hospital, HUST

for Headache

Sponsor: Tongji Hospital

Sex: All·Age: 6 - 70

Code: NCT07269561

Apply to this trial

BLOCK-SAH - PPF-Block for Post-SAH Headache

for Subarachnoid Hemorrhage, Aneurysmal

13 sites incl. Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 85

Code: NCT06008795·Phase 2

Apply to this trial

Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches

for Brain Concussion

1 site in Syracuse

Sponsor: State University of New York - Upstate Medical University

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06112093·Phase 1

Apply to this trial

Responding With Evidence and Access for Childhood Headaches

for Headache

15 sites incl. Birmingham

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 17

Code: NCT05889624

Apply to this trial

Differences in Characteristics of Headache Patients With a Positive or Negative FRT: a Cross-sectional Comparison.

for Headache

Sponsor: University Ghent

Sex: All·Age: 18+

Code: NCT06134791

Apply to this trial

Determining the Utility of a Behavioral Intervention in Chronic Migraine

for Migraine

1 site in Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05415020

Apply to this trial

Percutaneous Needle Electrolysis (PNE) on the Concha of the Ear

for Headache

Sponsor: University of Alcala

Sex: All·Age: 18 - 70

Code: NCT05662722

Apply to this trial

Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

for TBI (Traumatic Brain Injury)

1 site in San Diego

Sponsor: Veterans Medical Research Foundation

Sex: All·Age: 18 - 65

Code: NCT05176392

Apply to this trial

Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches

for Post-Concussion Syndrome

1 site in Manhasset

Sponsor: Northwell Health

Sex: All·Age: 18+

Code: NCT04685772

Apply to this trial

Mind Body Balance for Pediatric Migraine

for Headache

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 17

Code: NCT04715685

Apply to this trial

Headache clinical trials — common questions

Are headache clinical trials free to join?

Yes. Participating in a headache clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a headache clinical trial?

Each headache study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a headache trial near me?

Use the location controls above. We'll show recruiting headache trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many headache trials are recruiting right now?

We're currently tracking roughly 21 recruiting headache trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Headache trials by city

Gainesville, FL San Diego, CA Aurora, CO Birmingham, AL Cincinnati, OH Dayton, OH Sacramento, CA Seattle, WA

Related specialties

Neurology