Paid Clinical Trials in Springfield, MA

As of August 2026, 74 paid clinical trials are recruiting in Springfield, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Springfield offers studies at sites including Baystate Medical Center for conditions such as Alzheimer Disease, Coronary Artery Disease, Opioid Use Disorder, Stroke. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .

Trials by specialty in Springfield

Oncology· 12Neurology· 12Brain disorders· 10Behavioral health· 9Cardiology· 7Heart disease· 7Women's health· 7Dementia care· 5Addiction medicine· 5Geriatrics· 5Psychiatry· 4Mental health· 4

Trials by drug in Springfield

Dexamethasone· 2Apixaban· 1Folinic acid· 1Mammography· 1Methotrexate· 1Palbociclib· 1Prednisolone· 1Prednisone· 1Pulmonary function testing.· 1
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Newly added in Springfield

Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.

70 clinical trials

Top Research Study Locations in Springfield

Researchers run research studies in Springfield, MA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.

SiteSpecializes inActive trials
Baystate Medical CenterStroke, Anatomic Stage II Breast Cancer AJCC v8, Atrial Fibrillation39
Baystate HealthCoronary Artery Disease, Heart Diseases, Chronic Obstructive Pulmonary Disease4
Elixia MAAlzheimer Disease, Bipolar Disorder, Treatment Resistant Depression3
Elixia Health - Springfield - Elixia - PPDSAlzheimer Disease, Type II Diabetes Mellitus2
New England Retina ConsultantsDME, Diabetic Macular Edema, Diabetic Macular Edema (DME)2
Elixia - SpringfieldGeneralized Anxiety Disorder (GAD), Bipolar I or II Disorder2
Baystate Children's HospitalBronchiolitis Acute1
Baystate Clinical Trials UnitOSA1
Baystate Pain Management CenterLumbar Spinal Stenosis1
Behavioral Health NetworkMental Health Disorder, Opioid Use Disorder1
Caring Health CenterBreast Cancer Screening, Cervical Cancer Screening, Colon Cancer Screening1
Direct Biologics Investigational SiteARDS, Acute Respiratory Distress Syndrome1
ELIXIAMajor Depressive Disorder1
Ear, Nose, & Throat Surgeons of Western New EnglandFacial Pain or Pressure, Headache, Migraine1
Elixia MA, LLCMajor Depressive Disorder1
Elixia SISU BHR - SprinfieldChronic Idiopathic Constipation (CIC)1
Elixia SISU BHR - SpringfieldCortisol Excess, Type 2 Diabetes1
Kidney Care and Transplant Services of NEArteriovenous Fistula, End-stage Renal Disease, Kidney Disease, End-Stage1
Local Institution - 1239Psychosis Associated With Alzheimer's Disease1
New England Retina Consultants, PCAge-related Macular Degeneration (AMD), Geographic Atrophy (GA)1
RAYUS RadiologyKnee Arthritis, Osteoarthritis1
Retina Research Institute at New England Retina ConsultantsAge - Related Macular Degeneration (AMD), Geographic Atrophy (GA)1
Retina Research Institute at New England Retina Consultants, PCAge-Related Macular Degeneration, Choroidal Neovascularization, Macular Degeneration1
Sisu BHR, LLCAD, Alzheimer Disease, Cognitive Impairment1
Site 0263 - Baystate Medical CenterHigh-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer1

Active & Upcoming Studies in Springfield (2026)

Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.

Cancer & tumors (22 active studies)

Mental health & behavior (9 active studies)

Neurology & pain (7 active studies)

Cardiovascular (5 active studies)

Eye & vision (5 active studies)

Diabetes & metabolic (2 active studies)

HIV / STI (1 active study)

Common conditions studied in Springfield

Leading research sponsors in Springfield

  • Baystate Medical Center
  • Children's Oncology Group
  • National Cancer Institute (NCI)
  • SWOG Cancer Research Network
  • Alliance for Clinical Trials in Oncology

Frequently asked questions

How many paid clinical trials are currently recruiting in Springfield?

There are approximately 74 recruiting clinical trials in Springfield, Massachusetts listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Springfield pay participants?

Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Springfield?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Springfield?

The most common conditions under active study in Springfield include Alzheimer Disease (3), Coronary Artery Disease (3), Opioid Use Disorder (3), Stroke (3), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Springfield?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Springfield?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Where can I take part in paid clinical trials in Springfield?

Recruiting research sites in Springfield include Baystate Medical Center, Baystate Health, Elixia MA, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.

What kinds of studies are recruiting in Springfield right now?

The largest active categories in Springfield are Cancer & tumors (22), Mental health & behavior (9), Neurology & pain (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.

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Other cities in Massachusetts

Boston, MA(2,890)Worcester, MA(203)Burlington, MA(85)Waltham, MA(57)Cambridge, MA(48)Belmont, MA(46)Charlestown, MA(41)Foxborough, MA(35)Newton, MA(33)Watertown, MA(29)Methuen, MA(24)Milford, MA(24)Peabody, MA(24)Brighton, MA(23)New Bedford, MA(22)Beverly, MA(18)Chestnut Hill, MA(18)South Weymouth, MA(17)Fall River, MA(14)Gloucester, MA(14)Brookline, MA(12)Bedford, MA(11)Plymouth, MA(10)Stoneham, MA(10)Lowell, MA(9)Needham, MA(9)Quincy, MA(9)Weymouth, MA(9)Danvers, MA(8)Lexington, MA(8)North Dartmouth, MA(8)Natick, MA(7)South Dartmouth, MA(7)Amherst, MA(6)Framingham, MA(6)Jamaica Plain, MA(6)Winchester, MA(6)Roslindale, MA(5)Salem, MA(5)Wellesley, MA(5)Westborough, MA(5)Andover, MA(4)Holyoke, MA(4)Malden, MA(4)Marlborough, MA(4)North Worcester, MA(4)Somerville, MA(4)Braintree, MA(3)Brockton, MA(3)Fairhaven, MA(3)Lawrence, MA(3)Pittsfield, MA(3)Shrewsbury, MA(3)West Roxbury, MA(3)Acton, MA(2)Allston, MA(2)Chelsea, MA(2)Hyannis, MA(2)Hyde Park, MA(2)Medford, MA(2)

Related healthcare resources in Massachusetts

Latest Massachusetts clinical trials research report

Trials by condition in Springfield

Alzheimer Disease· 3Stroke· 3Atrial Fibrillation· 2