Mesothelioma Clinical Trials

Recruiting mesothelioma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat mesothelioma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting mesothelioma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting mesothelioma trials

Within

FAPI PET Imaging - An Exploratory Study

for Thyroid Pathology

Sponsor: Martin Huellner

Sex: All·Age: 18+

Code: NCT07705074·Phase 1, Phase 2

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

3 sites incl. Denver

Sponsor: SHY Therapeutics

Sex: All·Age: 18+

Code: NCT07705334·Phase 1

Apply to this trial

SELECTmeso A Trial for Patients With Relapsed Malignant Mesothelioma SELECTmeso1 A Trial of BMS-986504 in Patients With MTAP-deficient Relapsed Mesothelioma

for Mesothelioma

Sponsor: University of Southampton

Sex: All·Age: 18+

Code: NCT07602946·Phase 2

Iparomlimab Plus Tovorilimab Combined With Bevacizumab and Chemotherapy as First-Line Treatment for Advanced Mesothelioma

for Mesothelioma

Sponsor: Fudan University

Sex: All·Age: 18 - 75

Code: NCT07514793·Phase 2

A 2-part Phase 1/2 Open-label Trial on ODM-212

for Mesothelioma

2 sites incl. Irving

Sponsor: Orion Corporation, Orion Pharma

Sex: All·Age: 18+

Code: NCT07563738·Phase 1, Phase 2

Apply to this trial

An Open-label, Single-arm Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile, and Preliminary Efficacy of KT032 Cell Injection in Patients With Mesothelin-positive Advanced Solid Tumors.

for Ovarian Cancer

Sponsor: Weijia Fang, MD

Sex: All·Age: 18 - 75

Code: NCT07420010·EARLY_Phase 1

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

for NSCLC Adenocarcinoma

15 sites incl. Santa Rosa

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT07277413·Phase 1

Apply to this trial

Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma

for Mesothelioma

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07126509

Apply to this trial

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

for Sarcoma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06503146·Phase 2

Apply to this trial

Study of Iparomlimab and Tuvonralimab Plus Chemotherapy in Malignant Mesothelioma

for Malignant Mesothelioma

Sponsor: National Cancer Center, China

Sex: All·Age: 18 - 75

Code: NCT07131345·Phase 1, Phase 2

Prospective Data Collection Initiative on Thoracic Malignancies

for Lung Cancer

Sponsor: Dutch Society of Physicians for Pulmonology and Tuberculosis

Sex: All·Age: 18+

Code: NCT06996249

Apply to this trial

A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Products

for Solid Tumor Cancer

3 sites incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06885424

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

for Mesothelioma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06885697·Phase 1

Apply to this trial

Lead-212 PSV359 Therapy for Patients With Solid Tumors

for Pancreatic Ductal Adenocarcinoma

11 sites incl. Miami

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06710756·Phase 1, Phase 2

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Phase 1 Dose Escalation and Expansion to Evaluate AROG4-01 in Patients With Advanced Solid Tumors

for Solid Tumors (Phase 1)

Sponsor: Aromics Therapeutics

Sex: All·Age: 18+

Code: NCT06652529·Phase 1

An International Study on Pediatric Patients With Rare Tumors.

for Paraganglioma/ Phaeochromocytoma

Sponsor: Azienda Ospedaliera di Padova

Sex: All·Age: 0 - 18

Code: NCT07072143

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A Study of VET3-TGI in Patients With Solid Tumors

for Solid Tumor, Adult

7 sites incl. Los Angeles

Sponsor: KaliVir Immunotherapeutics

Sex: All·Age: 18+

Code: NCT06444815·Phase 1

Apply to this trial

New Preclinical and Clinical Approaches to Mesothelioma

for Mesothelioma

Sponsor: Marco Emilio Bianchi

Sex: All·Age: All ages

Code: NCT06536179

Apply to this trial

Agnostic Therapy in Rare Solid Tumors

for Urachal Cancer

Sponsor: Instituto do Cancer do Estado de São Paulo

Sex: All·Age: 18+

Code: NCT06638931·Phase 2

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Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma

for Mesothelioma

2 sites incl. Durham

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05932199·Phase 1, Phase 2

Apply to this trial

A Study of BGC515 Capsules in Subjects With Advanced Solid Tumors

for Mesothelioma

1 site in Houston

Sponsor: BridGene Biosciences Inc.

Sex: All·Age: 18+

Code: NCT06452160·Phase 1

Apply to this trial

A Study of Sacituzumab Govitecan in People With Mesothelioma

for Mesothelioma

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06477419·Phase 2

Apply to this trial

GPC3/Mesothelin-CAR-γδT Cells Against Cancers

for Pancreas Cancer

Sponsor: Second Affiliated Hospital of Guangzhou Medical University

Sex: All·Age: 18 - 75

Code: NCT06196294·Phase 1

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A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

for Solid Tumor, Adult

12 sites incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06051695·Phase 1, Phase 2

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EXTRA-Meso (EXercise TheRApy in Mesothelioma) Feasibility

for Mesothelioma

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 18+

Code: NCT06491784

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Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU

for Pulmonary Edema

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06538376

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Immune Microenvironment and Gene Expression Profiling in Mesothelioma

for Mesothelioma

Sponsor: Istituto Oncologico Veneto IRCCS

Sex: All·Age: 18+

Code: NCT06581549

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A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

for Advanced Solid Tumor

13 sites incl. Phoenix

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05873686·Phase 1

Apply to this trial

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

for Malignant Peritoneal Mesothelioma

13 sites incl. Chicago

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06057935·Phase 2

Apply to this trial

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

for Mesothelioma

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05730816·Phase 2

Apply to this trial

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

for High Grade Epithelial Ovarian Cancer

37 sites incl. Phoenix

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT05579366·Phase 1, Phase 2

Apply to this trial

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for Mesothelioma

22 sites incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05245500·Phase 1

Apply to this trial

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

for Triple Negative Breast Cancer

1 site in Baltimore

Sponsor: A&G Pharmaceutical Inc.

Sex: All·Age: 18+

Code: NCT05627960·Phase 1

Apply to this trial

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

for Solid Tumor, Adult

13 sites incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT04981119

Apply to this trial

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

for Familial Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 30 - 120·Accepts healthy volunteers

Code: NCT04431024

Apply to this trial

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

9 sites incl. San Francisco

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2

Apply to this trial

Olaparib in Patients With HRD Malignant Mesothelioma

for Mesothelioma

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04515836·Phase 2

Apply to this trial

Stereotactic Magnetic Resonance Guided Radiation Therapy

for Pancreas Cancer

2 sites in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04115254

Apply to this trial

Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1

for Mesothelioma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2+

Code: NCT03830229

Apply to this trial

Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

for Mesothelioma

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT03683680

Apply to this trial

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

for Head and Neck Carcinoma

14 sites incl. Santa Rosa

Sponsor: VM Oncology, LLC

Sex: All·Age: 18 - 80

Code: NCT03556228·Phase 1, Phase 2

Apply to this trial

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

for Uveal Melanoma

1 site in Columbus

Sponsor: Mohamed Abdel-Rahman

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04792463

Apply to this trial

Integrated Cancer Repository for Cancer Research

for Pancreatic Cancer

42 sites incl. Greenwood Village

Sponsor: University of Nebraska

Sex: All·Age: 19 - 110·Accepts healthy volunteers

Code: NCT02012699

Apply to this trial

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

for Thymoma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 100

Code: NCT01950572

Apply to this trial

Molecular Analysis of Thoracic Malignancies

for Thymus Cancer

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT01385722

Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies

for Pseudomyxoma Peritonei

Sponsor: Oslo University Hospital

Sex: All·Age: 18+

Code: NCT02073500

Apply to this trial

Mesothelioma clinical trials — common questions

Are mesothelioma clinical trials free to join?

Yes. Participating in a mesothelioma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a mesothelioma clinical trial?

Each mesothelioma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a mesothelioma trial near me?

Use the location controls above. We'll show recruiting mesothelioma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many mesothelioma trials are recruiting right now?

We're currently tracking roughly 33 recruiting mesothelioma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Mesothelioma trials by city

Boston, MA Chicago, IL Santa Rosa, CA Columbus, OH Denver, CO Los Angeles, CA Miami, FL San Francisco, CA Stanford, CA

Related specialties

Oncology Lung oncology