Myelodysplastic syndromes (MDS) Clinical Trials

Recruiting myelodysplastic syndromes (mds) studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat myelodysplastic syndromes (mds). Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting myelodysplastic syndromes (mds) studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting myelodysplastic syndromes (mds) trials

Within

Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome

for Acute Myeloid Leukemia With Complex Karyotype

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07582172·Phase 2

Prophylactic and Therapeutic DLI-X for Leukemia Relapse After HCT

for Acute Lymphoid Leukemia

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: Up to 65

Code: NCT07254793·Phase 1

Automated Total Marrow and Lymphoid Irradiation for Allogeneic Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18 - 70

Code: NCT07634536·Phase 2

A Pragmatic Clinical Trial to Prevent Relapse for Myeloid Malignancies With Measurable Disease Prior to Allogeneic Transplant

for Myeloid Disorders

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT07572929·Phase 2

Pacritinib With Aza for Upfront Myelodysplastic Syndrome

for Myelodysplastic Syndromes

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07387354·Phase 1, Phase 2

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

for Myelodysplastic Syndromes

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 120

Code: NCT06303193·Phase 1, Phase 2

Apply to this trial

Age-Stratified Conditioning Regimen Efficacy for MDS Haplo-HSCT

for Myelodysplastic Syndromes

Sponsor: Peking University People's Hospital

Sex: All·Age: 18 - 65

Code: NCT07677306·Phase 2

Dexamethasone, Intravenous Injection of Human Immunoglobulin, and Increased Infusion of Mononuclear Cells to Reduce Donor Specific Antibodies in Haploidentical Hematopoietic Stem Cell Transplantation

for Leukemia

Sponsor: Hematology department of the 920th hospital

Sex: All·Age: 18 - 65

Code: NCT07698080·Phase 2

Chidamide Monotherapy for Intermediate-to-High-Risk Myelodysplastic Syndromes

for Myelodysplastic Syndromes

Sponsor: Zhongshan Hospital (Xiamen), Fudan University

Sex: All·Age: 60+

Code: NCT07616336·Phase 2

TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT

for GVHD

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18 - 80

Code: NCT07302776·Phase 1

CD64 CAR T Cell Therapy in Adults With Relapsed and/or Refractory AML

for Refractory Acute Myeloid Leukemia (AML)

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07347418·Phase 1

Apply to this trial

eHealth Mindfulness-based Music Therapy Intervention for Patients Undergoing Stem Cell Transplantation

for Stem Cell Transplantation

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07469592

Use of Electrical Bioimpedance in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Patients (Bioimpedance)

for Myelodysplastic Syndromes

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT07570056

Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation

for Acute Leukemia

1 site in Palo Alto

Sponsor: Laguna Biotherapeutics, Inc.

Sex: All·Age: 18 Months - 39

Code: NCT07573111·Phase 1

A Trial Comparing Three Different Treatment Options for Adults With Low-Risk Myelodysplasia and Anemia (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07463820·Phase 2

Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75

Code: NCT06996119·Phase 1

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Study of NK Cells in the Monitoring of Patients With Acute Leukemia or Myelodysplasia

for Leukaemia (Acute Myeloid)

Sponsor: Nantes University Hospital

Sex: All·Age: 18+

Code: NCT07249476

Phase I Study of FXS0683 in the Treatment of Blood Tumors

for B-Cell Lymphoma

Sponsor: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.

Sex: All·Age: 18+

Code: NCT07616089·Phase 1

Study of an Innovative Therapy Using CAR-T Cells Targeting IL-1RAP in Patients With High-Risk Myelodysplastic Syndromes (MDS

for Myelodysplastic Syndrome

Sponsor: University Hospital, Grenoble

Sex: All·Age: All ages

Code: NCT07455500

A Study of BL-M11D1 in Patients With Relapsed/Refractory Myelodysplastic Syndromes

for Myelodysplastic Syndromes

Sponsor: Sichuan Baili Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07591168·Phase 1, Phase 2

Testing the Use of an IDH1 Inhibitor, Olutasidenib, in Acute Myeloid Leukemia Added to ASTX727 and Venetoclax; in High-Risk MDS Added to ASTX727; and Alone in Low Risk MDS (A MyeloMATCH Treatment Substudy)

for Acute Myeloid Leukemia

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07153497·Phase 2

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

25 sites incl. Gilbert

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3

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Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial)

for Clonal Cytopenia of Undetermined Significance

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07579429·Phase 2

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A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

for Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

3 sites incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07020533·Phase 1

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Clonal Hematopoiesis of Immunological Significance

for Immune System Diseases

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT05969821

Cord Blood Transplantation in Children and Young Adults With Blood Cancer

for Acute Myelogenous Leukemia

1 site in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: Up to 26

Code: NCT07566377·Phase 2

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A Study of TAK-226 for Anemia in Japanese Patients With Lower-Risk Myelodysplastic Syndromes

for Myelodysplastic Syndromes

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07319845·Phase 2

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MT2025-35 Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning Treosulfan and Fludarabine, With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological Diseases

for AML

1 site in Minneapolis

Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All·Age: 2 - 75

Code: NCT07493538·Phase 2

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Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS

for Acute Myeloid Leukemia

1 site in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT07270978·Phase 1

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Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia

for Chronic Myelomonocytic Leukemia

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18 - 100

Code: NCT07071155·EARLY_Phase 1

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Ascorbate in Myelodysplastic Syndrome

for Myelodysplastic Syndromes

1 site in Iowa City

Sponsor: Prajwal Dhakal

Sex: All·Age: 18 - 99

Code: NCT07283900·Phase 2

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IFN-α in Relapse Prevention.

for Acute Myeloid Leukemia

Sponsor: Peking University People's Hospital

Sex: All·Age: 12 - 65

Code: NCT07449286·Phase 2

Safety and Proof-of-Concept Study of RPT1G in Adults With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

for Acute Myeloid Leukemia

2 sites incl. New York

Sponsor: Remedy Plan, Inc.

Sex: All·Age: 18+

Code: NCT07107126·Phase 1

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FHD-286 With Low-Dose Weekly Decitabine/Venetoclax in Patients With Acute Myeloid Leukemia

for Acute Myeloid Leukemia

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT07283094·Phase 1

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Feasibility Trial of Extracorporeal Iron Purification in Patients With Myelodysplastic Syndrome or Myelofibrosis

for Myelodysplastic Syndrome

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT06781099

Apply to this trial

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for Amyloidosis

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07285044·Phase 2

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Induction and Consolidation With Fludarabine, Cytarabine, Idarubicin, and Venetoclax for the Treatment of Acute Myeloid Leukemia

for Acute Myeloid Leukemia

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18 - 65

Code: NCT07228273·Phase 2

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Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

for Leukemia, Myeloid, Acute

6 sites incl. Los Angeles

Sponsor: Orca Biosystems, Inc.

Sex: All·Age: 18+

Code: NCT07216443·Phase 2

Apply to this trial

Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

for Acute Myeloid Leukemia

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18 - 70

Code: NCT06551584·Phase 1

Apply to this trial

Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS

for Aplastic Anemia

Sponsor: Institute of Hematology & Blood Diseases Hospital, China

Sex: All·Age: 18 - 65

Code: NCT07578675

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Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer

for Acute Leukemia of Ambiguous Lineage

1 site in Seattle

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT07046078·Phase 2

Apply to this trial

HEME Home Transfusion Program

for Leukemia

2 sites in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06487247

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Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia

for Myelodysplastic Syndromes

Sponsor: University of Manitoba

Sex: All·Age: 18+

Code: NCT06599762·Phase 2

Apply to this trial

Molecular and Clinical Analysis of Bone Marrow Failure: A Secondary Research Study

for Bone Marrow Failure Disorders

1 site in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 2 - 120

Code: NCT07102849

Venetoclax-Enhanced BUCY vs. Standard BUCY Conditioning in High-Risk AML and MDS Patients Undergoing Allo-HSCT (Ven-BUCY Study)

for Acute Myeloid Leukemia

Sponsor: First Affiliated Hospital of Zhejiang University

Sex: All·Age: 12 - 60

Code: NCT07183878

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Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for Acute Myeloid Leukemia

19 sites incl. New Haven

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06484062·Phase 1

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Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood

for aGVHD

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06904482·Phase 2

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Efficacy of Immediate Allogeneic Hematopoietic Stem Cell Transplantation Versus Bridging Therapy Followed by Transplantation in Higher-Risk Myelodysplastic Syndrome Patients

for Myelodysplastic Syndromes

Sponsor: Institute of Hematology & Blood Diseases Hospital, China

Sex: All·Age: 18+

Code: NCT06918834·Phase 2

Apply to this trial

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

for Germline Mutation

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 Month - 120

Code: NCT07019155

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Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies

for Myeloid Malignancy

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 75

Code: NCT07044544·Phase 1

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Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes

for Myelodysplastic Syndromes

1 site in Morgantown

Sponsor: West Virginia University

Sex: All·Age: 18+

Code: NCT06923488·Phase 1, Phase 2

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225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06287944·Phase 1

Apply to this trial

Venetoclax-containing Therapy Combined With Microtransplant for Intermediate-risk and Higher MDS

for Myelodysplastic Syndromes

Sponsor: Beijing 302 Hospital

Sex: All·Age: 18+

Code: NCT07238686·Phase 2

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

140 sites incl. Berkeley

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2

Apply to this trial

A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

for Myelodysplastic Syndromes

6 sites incl. Goodyear

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06847867·Phase 2

Apply to this trial

Home Blood Transfusions

for Hematologic Malignancy

1 site in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07121140

Apply to this trial

Reduced ATG Plus Mini PTCy for GVHD Prophylaxis in Haplo-SCT

for Myelodysplastic Syndrome

Sponsor: Peking University People's Hospital

Sex: All·Age: 12 - 65

Code: NCT06984536·Phase 2

Apply to this trial

Vaccination Against Human Papillomavirus (HPV) After Allogeneic Stem Cell Transplantation

for Recipients of Allogeneic Stem Cell Transplantation

Sponsor: Vastra Gotaland Region

Sex: All·Age: 18 - 45

Code: NCT06793410·Phase 2

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A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndromes

23 sites incl. Duarte

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06499285·Phase 3

Apply to this trial

Mosaic Trial for Stem Cell Transplant Recipients

for Hematologic Malignancy

3 sites incl. Washington D.C.

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06960993

Apply to this trial

Myelodysplastic syndromes (MDS) clinical trials — common questions

Are myelodysplastic syndromes (mds) clinical trials free to join?

Yes. Participating in a myelodysplastic syndromes (mds) clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a myelodysplastic syndromes (mds) clinical trial?

Each myelodysplastic syndromes (mds) study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a myelodysplastic syndromes (mds) trial near me?

Use the location controls above. We'll show recruiting myelodysplastic syndromes (mds) trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many myelodysplastic syndromes (mds) trials are recruiting right now?

We're currently tracking roughly 141 recruiting myelodysplastic syndromes (mds) trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Myelodysplastic syndromes (MDS) trials by city

Duarte, CA Birmingham, AL Boston, MA Seattle, WA Jacksonville, FL Los Angeles, CA Palo Alto, CA Cleveland, OH Miami, FL Tampa, FL Aurora, CO Milwaukee, WI

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