Sickle cell disease Clinical Trials

Recruiting sickle cell disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat sickle cell disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting sickle cell disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting sickle cell disease trials

Within

Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease

for Sickle Cell Disease

1 site in Hartford

Sponsor: Connecticut Children's Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07540767

Feasibilty and Acceptability of Amani

for Sickle Cell Disease

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07648043·EARLY_Phase 1

Minocycline In Neurocognitive Outcomes - Sickle Cell Disease

for Sickle Cell Disease

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05605366·Phase 1

CS-206 in Patients With Sickle Cell Disease

for Sickle Cell Disease

Sponsor: Children's Hospital of Fudan University

Sex: All·Age: 12 - 18

Code: NCT07000318·EARLY_Phase 1

Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease

for Vaso-Occlusive Crises

Sponsor: University Hospital, Rouen

Sex: All·Age: 18+

Code: NCT07498309·Phase 3

Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease

for Sickle Cell Disease

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 22

Code: NCT07616154·Phase 2

Transcranial Photobiomodulation Treatment in Patients With Sickle Cell Disease

for Sickle Cell Disease

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 8 - 17

Code: NCT06797583

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

for Sickle Cell Disease

Sponsor: Agios Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07656415·Phase 3

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease

for Sickle Cell Disease

1 site in Boston

Sponsor: Daniel Bauer

Sex: All·Age: 13 - 40

Code: NCT07708350·Phase 1

Universal Newborn Screening For Sickle Cell Disease In Mozambique

for Sickle Cell Disease

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07719972

Early Life Exposures Among Children With Sickle Cell Disease

for Sickle Cell Disease

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT05377372

Apply to this trial

Virtual Reality for SCD VOC

for Sickle Cell Disease

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 89

Code: NCT07674277

Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing

for Sickle Cell Disease

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 8 - 18

Code: NCT07562451

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

for Sickle Cell Disease

1 site in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 4 - 65

Code: NCT07599176·Phase 1, Phase 2

Apply to this trial

Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

for Sickle Cell Disease

4 sites incl. Aurora

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 12 - 45

Code: NCT07252050·Phase 1, Phase 2

Apply to this trial

Functional Ovarian Reserve in Sickle Cell Disease

for Sickle Cell Disease

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: Female·Age: 10 - 18·Accepts healthy volunteers

Code: NCT07392216

Apply to this trial

STEM CELL MOBILIZATION WITH HIGH-DOSE PLERIXAFOR IN PATIENTS WITH SICKLE CELL DISEASE

for Sickle Cell Disease

Sponsor: Hospital Israelita Albert Einstein

Sex: All·Age: 18 - 25

Code: NCT07341022·Phase 1, Phase 2

Optimizing Hydroxyurea Therapy in Children With Sickle Cell Anemia In Malaria Endemic Areas: The NOHARM Maximum Tolerated Dose (MTD) Study

for Sickle Cell Disease

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 11 - 18

Code: NCT07708714·Phase 1, Phase 2

Apply to this trial

Hydroxyurea Optimisation in Sickle Cell Disease

for Sickle Cell Disease

Sponsor: Ochuko Orherhe

Sex: All·Age: 18+

Code: NCT07543289

Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease

for Sickle Cell Disease

1 site in Atlanta

Sponsor: Emory University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06979492·Phase 4

Apply to this trial

SickleFit Exercise and Nutrition Study

for Sickle Cell Disease

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 35+

Code: NCT07442851

Apply to this trial

Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

for Sickle Cell Disease

1 site in Torrance

Sponsor: Mohsen Saidinejad

Sex: All·Age: 5 - 20

Code: NCT07369024·Phase 2

Apply to this trial

Open-Label Extension Study to Pioneer Study 6058-SCD-101

for Sickle Cell Disease

8 sites incl. Little Rock

Sponsor: Fulcrum Therapeutics

Sex: All·Age: 18+

Code: NCT07401823·Phase 2

Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening

for Sickle Cell Disease

Sponsor: Makerere University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07610239

Apply to this trial

Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

for Sickle Cell Disease

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18 - 80

Code: NCT06016634·Phase 2

Apply to this trial

Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care

for Sickle Cell Disease

Sponsor: University Hospital, Tours

Sex: All·Age: 18+

Code: NCT07246265

Apply to this trial

Safety and Efficacy of KL003 Cell Injection in Severe Sickle Cell Disease

for Sickle Cell Disease

Sponsor: Institute of Hematology & Blood Diseases Hospital, China

Sex: All·Age: 12 - 50

Code: NCT07436767

Optimal Timing of Ketamine Initiation for SCD Pain

for Sickle Cell Disease

1 site in Brookline

Sponsor: Boston Children's Hospital

Sex: All·Age: 6 - 24

Code: NCT07450430·Phase 3

Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.

for Sickle Cell Disease

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 12 - 35

Code: NCT07432867·Phase 1, Phase 2

Apply to this trial

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

for Sickle Cell Disease

6 sites incl. Oakland

Sponsor: University of California, San Francisco

Sex: All·Age: 15 - 40

Code: NCT06260891·Phase 2

Apply to this trial

Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease

for Sickle Cell Disease

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 11 - 18

Code: NCT07222475

Apply to this trial

Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

for Sickle Cell Disease

5 sites incl. Little Rock

Sponsor: CSL Behring

Sex: All·Age: 18+

Code: NCT07224360·Phase 2

Apply to this trial

Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype

for Sickle Cell Disease

Sponsor: Biossil Inc.

Sex: All·Age: 16 - 35

Code: NCT07282210·Phase 2

Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease

for Sickle Cell Disease

5 sites incl. Atlanta

Sponsor: Sanofi

Sex: All·Age: 2 - 17

Code: NCT07247188·Phase 3

Apply to this trial

Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

for Sickle Cell Disease

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07316478

Apply to this trial

Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease

for Sickle Cell Disease

4 sites incl. Chicago

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06919224

Apply to this trial

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

for Sickle Cell Disease

7 sites incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT07187973·Phase 1

Apply to this trial

A Long-term Follow-up Study in Patients Who Received BEAM-101

for Hemoglobinopathy

17 sites incl. Birmingham

Sponsor: Beam Therapeutics Inc.

Sex: All·Age: 14 - 37

Code: NCT07373639

Apply to this trial

Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease

for Chronic Pain

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 15 - 39

Code: NCT07402811

Apply to this trial

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

for Sickle Cell Disease

1 site in Boston

Sponsor: Daniel Bauer

Sex: All·Age: 13 - 40

Code: NCT06647979·Phase 1

Apply to this trial

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

for Sickle Cell Disease

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 8 - 17

Code: NCT07226219·Phase 1

Apply to this trial

Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell Disease

for Sickle Cell Disease

Sponsor: Assiut University

Sex: All·Age: 1 - 18

Code: NCT07200869

Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease

for Sickle Cell Disease

1 site in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 8 - 25

Code: NCT06555939

Apply to this trial

Early Screening and Treatment of Heart Complication in Sickle Cell Disease

for Sickle Cell Disease

2 sites incl. Fairfax

Sponsor: Inova Health Care Services

Sex: All·Age: 18+

Code: NCT07023666·Phase 2

Apply to this trial

Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell Disease

for Sickle Cell Disease

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 2+

Code: NCT06818266·Phase 3

Apply to this trial

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

for Sickle Cell Disease

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 14 - 80

Code: NCT06725550

Apply to this trial

Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

for Sickle Cell Disease

2 sites incl. Los Angeles

Sponsor: Mark Walters, MD

Sex: All·Age: 12 - 35

Code: NCT04774536·Phase 1, Phase 2

Apply to this trial

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

for Sickle Cell Disease

16 sites incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 10 - 65

Code: NCT06975865·Phase 3

Apply to this trial

Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

for Sickle Cell Disease

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 7 - 18

Code: NCT07090668

Apply to this trial

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

for Sickle Cell Disease

6 sites incl. Washington D.C.

Sponsor: Asklepion Pharmaceuticals, LLC

Sex: All·Age: 6 - 21

Code: NCT06989567·Phase 3

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

for Sickle Cell Disease

1 site in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 2 - 99

Code: NCT06944067

Apply to this trial

PASS of Xromi Comparing Safety and Effectiveness in Children Under 2 Years With Sickle Cell Disease [PRECISE PASS]

for Sickle Cell Disease

Sponsor: Nova Laboratories Limited

Sex: All·Age: 9 Months - 23 Months

Code: NCT06923111

Apply to this trial

Ultrasound Acute Chest Syndrome Sickle Cell Disease

for Acute Chest Syndrome

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: Up to 25

Code: NCT06880679

Apply to this trial

Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain

for Sickle Cell Disease

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT05519111·Phase 2

Apply to this trial

Cannabidiol in Sickle Cell Disease

for Sickle Cell Disease

1 site in Manhattan

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT06930703·Phase 1, Phase 2

Apply to this trial

MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease

for Sickle Cell Disease

2 sites incl. Cleveland

Sponsor: University of California, Irvine

Sex: All·Age: 14+

Code: NCT06853158

Apply to this trial

School Readiness Intervention for Preschool Children With Sickle Cell Disease

for Sickle Cell Disease

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 42 Months - 78 Months

Code: NCT06367192

Apply to this trial

Gene Editing For Sickle Cell Disease

for Sickle Cell Disease

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 18 - 24

Code: NCT06506461·Phase 1

Apply to this trial

Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease

for Sickle Cell Disease

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 6 Months - 6

Code: NCT07356050

Apply to this trial

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

for Pain

14 sites incl. Mobile

Sponsor: University of Pittsburgh

Sex: All·Age: 16 - 30

Code: NCT06374238

Apply to this trial

Sickle cell disease clinical trials — common questions

Are sickle cell disease clinical trials free to join?

Yes. Participating in a sickle cell disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a sickle cell disease clinical trial?

Each sickle cell disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a sickle cell disease trial near me?

Use the location controls above. We'll show recruiting sickle cell disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many sickle cell disease trials are recruiting right now?

We're currently tracking roughly 115 recruiting sickle cell disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Sickle cell disease trials by city

Birmingham, AL Chicago, IL Boston, MA Los Angeles, CA Oakland, CA Cincinnati, OH Cleveland, OH Duarte, CA Indianapolis, IN Little Rock, AR Aurora, CO Gainesville, FL