Soft tissue sarcoma Clinical Trials

Recruiting soft tissue sarcoma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat soft tissue sarcoma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting soft tissue sarcoma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting soft tissue sarcoma trials

Within

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

for Pediatric Solid Tumors

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT07514819

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

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Preoperative Immunonutrition in Patients With Bone and Soft Tissue Sarcomas

for Bone Sarcoma

Sponsor: St. Anne's University Hospital Brno, Czech Republic

Sex: All·Age: All ages

Code: NCT07609329

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Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy

for Soft Tissue Sarcoma

1 site in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07436364·EARLY_Phase 1

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Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

for Melanoma

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05264974·Phase 1

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Prospective Phase I/II Study Evaluating the Safety and Efficacy of Preoperative Carbon Ion Radiotherapy in Patients With Soft Tissue Sarcoma : The SARCOMA-01 Trial by the Severance sARCOma Multidisciplinary Team

for Soft Tissue Sarcoma

Sponsor: Yonsei University

Sex: All·Age: 19+

Code: NCT07250334

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

for Pancreatic Ductal Adenocarcinoma

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07261631·Phase 1

Apply to this trial

Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas

for Osteosarcoma

Sponsor: Tcelltech Inc.

Sex: All·Age: 8+

Code: NCT07052383·Phase 1

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SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07049848·Phase 2

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Outcomes Following Limb Sparing Surgery for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Amsterdam UMC

Sex: All·Age: 18+

Code: NCT06962072

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A Study of MT-4561 in Patients With Various Advanced Solid Tumors

for Head and Neck Squamous Cell Carcinoma (HNSCC)

4 sites incl. Los Angeles

Sponsor: Tanabe Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT06943521·Phase 1, Phase 2

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tislelizUMaB in canceR Patients With molEcuLar residuaL Disease

for Cancer

Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Sex: All·Age: 18+

Code: NCT06332274·Phase 3

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Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06905132·Phase 2

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Investigative Analysis of Soft Tissue Sarcoma Clinical Trials: An Observational Study

for Soft Tissue Sarcoma

1 site in San Francisco

Sponsor: Power Life Sciences Inc.

Sex: All·Age: 18+

Code: NCT06264505

Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy

for Oral Cancer

Sponsor: University Medical Center Groningen

Sex: All·Age: 18+

Code: NCT06726512

Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma

for Adult Pleomorphic Rhabdomyosarcoma

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 1 - 85

Code: NCT06526897

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

for Solid Tumour

Sponsor: Cancer Research UK

Sex: All·Age: 18+

Code: NCT06988475·Phase 2, Phase 3

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89Zr-olaratumab Dosimetry in Participants With Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Telix Pharmaceuticals (Innovations) Pty Ltd

Sex: All·Age: 18+

Code: NCT06537596·Phase 1

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68Ga-DOTATATE PET/CT for the Diagnosis of Soft Tissue Sarcomas

for Soft Tissue Sarcoma

1 site in Columbus

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06500065

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Efficacy and Safety of Envafolimab Plus Doxorubicin and Ifosfamide for Advanced Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18+

Code: NCT07243626·Phase 2

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Pemigatinib and Immune Checkpoint Inhibitor Treated FGFR1/2/3 Alteration Advanced Solid Tumor

for Urothelial Carcinoma

Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Sex: All·Age: 18+

Code: NCT06551896·Phase 2

Anlotinib Combined With Doxorubicin and Radiotherapy as Neoadjuvant Treatment for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Guangdong Provincial People's Hospital

Sex: All·Age: 18 - 75

Code: NCT06506838·Phase 4

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TQB2916 Injection Combined With Chemotherapy or Penpulimab Injection in the Treatment of Solid Tumors

for Soft Tissue Sarcoma

Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT06500091·Phase 2

Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI

for Pancreatic Adenocarcinoma

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT06333314·Phase 2

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Agnostic Therapy in Rare Solid Tumors

for Urachal Cancer

Sponsor: Instituto do Cancer do Estado de São Paulo

Sex: All·Age: 18+

Code: NCT06638931·Phase 2

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Clinical Trial of VIM With VIT in Children With Relapsed and Refractory Soft Tissue Sarcoma.

for Soft Tissue Sarcoma

Sponsor: Yizhuo Zhang

Sex: All·Age: 2 - 21

Code: NCT06514313·Phase 2

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Pre-operative Hypofractionated Proton Therapy

for Soft Tissue Sarcoma

1 site in Washington D.C.

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT05917301

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Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

for Bone Sarcoma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06409013

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IVIM & OLINK in Sarcoma

for Soft Tissue Sarcoma

Sponsor: University Health Network, Toronto

Sex: All·Age: 18 - 100

Code: NCT05950594·Phase 2

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Pazopanib With or Without Pembrolizumab for Metastatic Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Yonsei University

Sex: All·Age: 20 - 80

Code: NCT05679921·Phase 2

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Efficacy and Safety of Cadonilimab Plus Anlotinib in Advanced STS That Failed the Previous First-line Standard Treatment

for Soft Tissue Sarcoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18+

Code: NCT05926700·Phase 2

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A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.

for Soft Tissue Sarcoma

Sponsor: Institut Claudius Regaud

Sex: All·Age: 65+

Code: NCT06022159·Phase 2

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Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma

for Sarcoma

8 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06129903

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5-Day Preoperative Radiation for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06087861·Phase 2

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A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

for Soft Tissue Sarcoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 12+

Code: NCT05621668·Phase 1

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Study Comparing Negative Pressure Dressing vs Conventional in Patients With Resected STS After Radiotherapy

for Soft Tissue Sarcoma

Sponsor: Centre Leon Berard

Sex: All·Age: 18+

Code: NCT05944913

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A Study of ILB2109 and Toripalimab in Patients With Advanced Solid Malignancies

for Head and Neck Cancer

Sponsor: Innolake Biopharm

Sex: All·Age: 18 - 80

Code: NCT05955105·Phase 1, Phase 2

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A Clinical Study to Investigate the Efficacy of Intratumoral Tigilanol Tiglate in Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in New York

Sponsor: QBiotics Group Limited

Sex: All·Age: 18+

Code: NCT05755113·Phase 2

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Use of GnRHa During Chemotherapy for Fertility Protection

for Breast Cancer Female

Sponsor: Kenny Rodriguez-Wallberg

Sex: Female·Age: 14 - 42

Code: NCT05328258·Phase 3

Apply to this trial

Safety and Efficacy of Preoperative SBRT and Radical Surgery for Soft Tissue Sarcoma of Extremities

for Soft Tissue Sarcoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18 - 80

Code: NCT06760221

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Sarcoma Preoperative Radiation With Simultaneous INTegrated Boost (SPRINT)

for Soft Tissue Sarcoma

Sponsor: Azienda Ospedaliero-Universitaria Careggi

Sex: All·Age: 18+

Code: NCT05761054

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B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

for Pediatric Solid Tumor

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT04897321·Phase 1

Apply to this trial

Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05526417

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Genomic Risk in Retroperitoneal Sarcoma

for Retroperitoneal Liposarcoma

1 site in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06436846

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Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)

for Soft Tissue Sarcoma

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18+

Code: NCT05224934

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HIFU Ablation of Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Oxford University Hospitals NHS Trust

Sex: All·Age: 18+

Code: NCT05111964

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HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

for Sarcoma

1 site in Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 1 - 25

Code: NCT04995003·Phase 1

Apply to this trial

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

for Bile Duct Cancer

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05000294·Phase 1, Phase 2

Apply to this trial

Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

for Leiomyosarcoma of Ovary

Sponsor: Italian Sarcoma Group

Sex: All·Age: 18+

Code: NCT04383119·Phase 2

Apply to this trial

tTF-NGR Randomized Study - STS

for Soft Tissue Sarcoma

Sponsor: Universität Münster

Sex: All·Age: 18 - 75

Code: NCT05597917·Phase 3

Apply to this trial

Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients

for Soft Tissue Sarcoma

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18 - 95·Accepts healthy volunteers

Code: NCT05051059

Apply to this trial

Adriamycin and Ifosfamide Combined With Sintilimab

for Soft Tissue Sarcoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 14 - 70

Code: NCT04589754·Phase 2

Apply to this trial

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

for Salivary Gland Tumor

3 sites incl. New York

Sponsor: Avacta Life Sciences Ltd

Sex: All·Age: 18+

Code: NCT04969835·Phase 1

Apply to this trial

Exercise and Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85

Code: NCT04921917

Apply to this trial

Sequential Neoadjuvant Chemotherapy in Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Oslo University Hospital

Sex: All·Age: 18+

Code: NCT04776525·Phase 2

Apply to this trial

Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group

for Soft Tissue Sarcoma

Sponsor: Institut Claudius Regaud

Sex: All·Age: 18+

Code: NCT03967834

Apply to this trial

Toripalimab Combined With CAV/IE Regimen

for Soft Tissue Sarcoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 14 - 70

Code: NCT04589741·Phase 2

Apply to this trial

Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma

for Soft Tissue Sarcoma

Sponsor: Institut Claudius Regaud

Sex: All·Age: 18+

Code: NCT04307277·Phase 3

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Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 site in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT04577014·Phase 1, Phase 2

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A Phase II Study on Adjuvant Vaccination with Dendritic Cells Loaded with Autologous Tumor Homogenate in Resected Stage IV Rare Cancers.

for Head Neck Tumors

Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Sex: All·Age: 18+

Code: NCT04166006·Phase 2

Apply to this trial

Soft tissue sarcoma clinical trials — common questions

Are soft tissue sarcoma clinical trials free to join?

Yes. Participating in a soft tissue sarcoma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a soft tissue sarcoma clinical trial?

Each soft tissue sarcoma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a soft tissue sarcoma trial near me?

Use the location controls above. We'll show recruiting soft tissue sarcoma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many soft tissue sarcoma trials are recruiting right now?

We're currently tracking roughly 24 recruiting soft tissue sarcoma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Soft tissue sarcoma trials by city

Gainesville, FL Los Angeles, CA Columbus, OH Jacksonville, FL Orange, CA Palo Alto, CA San Francisco, CA

Related specialties

Oncology