Paid Clinical Trials in Frederick, MD
As of August 2026, 30 paid clinical trials are recruiting in Frederick, Maryland. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Frederick offers studies at sites including FMH James M Stockman Cancer Institute for conditions such as Breast Cancer, Colorectal Neoplasms, Neoplasm Metastasis, Addiction. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Frederick
Trials by drug in Frederick
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28 clinical trials
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
GEMINI-NSCLC: NSCLC Biomarker Study
TEMPUS ARIES: A Biobank Registry Platform Study in Oncology
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
C-Brace Prospective Registry
Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants
Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy
Molecular Genetics Studies of Cancer Patients and Their Relatives
Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage
Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
Top Research Study Locations in Frederick
Researchers run research studies in Frederick, MD at 17 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| FMH James M Stockman Cancer Institute | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8 | 6 |
| James M Stockman Cancer Institute | Neoplasm Metastasis, Breast Cancer, Breast Neoplasms | 6 |
| Frederick Health Hospital - James M Stockman Cancer Institute | Colorectal Neoplasms | 2 |
| Frederick Health Hospital- James M Stockman Cancer Institute | Extensive-stage Small-cell Lung Cancer, Non-small Cell Lung Cancer | 2 |
| Frederick Health Regional System | Cancer, Non-Small Cell Lung Cancer | 2 |
| Frederick Oncology Hematology Associates | Breast Cancer, Malignant Neoplasm | 2 |
| Ability x Ottobock.care | Lower Extremity, Pareses | 1 |
| Cumberland Valley Retina Consultants | Macular Telangiectasia Type 2 (MacTel) | 1 |
| Frederick County Health Department, Street Safe Program | Addiction, Drug Use, HIV Infections | 1 |
| Frederick Health Hospital | Advanced Solid Tumors Cancer, Bladder Cancer, Cancer | 1 |
| Frederick Memorial Hospital | Hypertension, Intracerebral Hemorrhage, Stroke | 1 |
| James M. Stockman Cancer Institute | Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis | 1 |
| Johns Hopkins Community Physicians Frederick | Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | 1 |
| Monocacy Surgery Center, LLC | Lumbar Spinal Stenosis | 1 |
| NCI Frederick Cancer Research Center | Healthy Donors | 1 |
| National Pain and Spine Centers | Lumbar Spinal Stenosis | 1 |
| Thomas Johnson Surgery Center | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Frederick (2026)
Recruiting trials in Frederick grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (18 active studies)
- A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract · Phase 3 · Eli Lilly and Company
- Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy · Phase 3 · Alliance for Clinical Trials in Oncology
HIV / STI (1 active study)
- Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation · Johns Hopkins University
Mental health & behavior (1 active study)
- Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation · Johns Hopkins University
Neurology & pain (1 active study)
- Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage · Zeenat Qureshi Stroke Institute
Cardiovascular (1 active study)
- Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage · Zeenat Qureshi Stroke Institute
Eye & vision (1 active study)
- Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants · Phase 4 · Neurotech Pharmaceuticals
Common conditions studied in Frederick
- Breast Cancer (3 active studies)
- Cancer (2 active studies)
- Colorectal Neoplasms (2 active studies)
- Neoplasm Metastasis (2 active studies)
- Addiction (1 active study)
- Advanced Solid Tumors Cancer (1 active study)
Leading research sponsors in Frederick
- Eli Lilly and Company
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- BioNTech SE
- Janssen Research & Development, LLC
Frequently asked questions
How many paid clinical trials are currently recruiting in Frederick?
There are approximately 30 recruiting clinical trials in Frederick, Maryland listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Frederick pay participants?
Most recruiting trials in Frederick compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Frederick?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Frederick?
The most common conditions under active study in Frederick include Breast Cancer (3), Cancer (2), Colorectal Neoplasms (2), Neoplasm Metastasis (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Frederick?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Frederick on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Frederick?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Frederick?
Recruiting research sites in Frederick include FMH James M Stockman Cancer Institute, James M Stockman Cancer Institute, Frederick Health Hospital - James M Stockman Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Frederick right now?
The largest active categories in Frederick are Cancer & tumors (18), HIV / STI (1), Mental health & behavior (1). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.