Paid Clinical Trials in Paducah, KY
As of July 2026, 30 paid clinical trials are recruiting in Paducah, Kentucky. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Paducah offers studies at sites including Mercy Health - Paducah Cancer Center for conditions such as Heart Failure, Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer, Breast Carcinoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Paducah
Trials by drug in Paducah
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Newly added in Paducah
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Implementation
27 clinical trials
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
Investigation of DEXA-C Anterior Cervical Interbody System
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
Mobile Health for Adherence in Breast Cancer Patients
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Top Research Study Locations in Paducah
Researchers run research studies in Paducah, KY at 14 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mercy Health - Paducah Cancer Center | Breast Carcinoma, Lung Cancer Screening, Malignant Solid Neoplasm | 9 |
| Baptist Health Paducah | Ovarian Carcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 5 |
| Mercy Health - Paducah Medical Oncology and Hematology | Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8 | 2 |
| Mercy Health-Paducah Cancer Center | Breast Cancer, Hematologic Malignancies, Solid Tumors | 2 |
| CON-10079, Paducah, KY | Heart Failure | 1 |
| FIN-10079, Paducah, KY | Heart Failure | 1 |
| Local Institution - 0502 | Non-small Cell Lung Cancer | 1 |
| Local Institution - 0698 | Carcinoma, Non-Small-Cell Lung | 1 |
| Mercy Health | Triple Negative Breast Cancer | 1 |
| Orthopaedic Institute of Western KY | Degenerative Disc Disease | 1 |
| Orthopaedic Institute of Western Kentucky | Degenerative Disc Disease, Spondylolisthesis | 1 |
| Paducah, KY Investigative | Acute Heart Failure, Heart Failure | 1 |
| Strenge Spine | Cervical Disc Disease | 1 |
| The Orthopaedic Institute | Degenerative Disc Disease(DDD) | 1 |
Active & Upcoming Studies in Paducah (2026)
Recruiting trials in Paducah grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (17 active studies)
- Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2) · Phase 3 · Celcuity Inc
- A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) · Phase 3 · Mirati Therapeutics Inc.
Cardiovascular (4 active studies)
- Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin · Phase 3 · AstraZeneca
- A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists · Phase 3 · Colorado Prevention Center
Common conditions studied in Paducah
- Heart Failure (4 active studies)
- Anatomic Stage IV Breast Cancer AJCC v8 (2 active studies)
- Breast Cancer (2 active studies)
- Breast Carcinoma (2 active studies)
- Degenerative Disc Disease (2 active studies)
- Lung Cancer Screening (2 active studies)
Leading research sponsors in Paducah
- SWOG Cancer Research Network
- NRG Oncology
- AstraZeneca
- Colorado Prevention Center
- ECOG-ACRIN Cancer Research Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Paducah?
There are approximately 30 recruiting clinical trials in Paducah, Kentucky listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Paducah pay participants?
Most recruiting trials in Paducah compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Paducah?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Paducah?
The most common conditions under active study in Paducah include Heart Failure (4), Anatomic Stage IV Breast Cancer AJCC v8 (2), Breast Cancer (2), Breast Carcinoma (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Paducah?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Paducah on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Paducah?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Paducah?
Recruiting research sites in Paducah include Mercy Health - Paducah Cancer Center, Baptist Health Paducah, Mercy Health - Paducah Medical Oncology and Hematology, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Paducah right now?
The largest active categories in Paducah are Cancer & tumors (17), Cardiovascular (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.