Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in New Haven, Hartford +46 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
Breast cancer Clinical Trials in New Haven, CT
As of August 2026, 23 paid clinical trials are recruiting for Breast cancer in New Haven, Connecticut. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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23 clinical trials for Breast cancer
·Clear filters· Email me when a new breast cancer trial opens in New Haven, CT.
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
for Breast Cancer
Sites in New Haven +171 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06492616·Phase 3·Recruiting·Listed Jul 2024
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
for Breast Cancer
Sites in New Haven +48 more locations
Sponsor: Greenwich LifeSciences, Inc.
Sex: All·Age: 18 - 100
Code: NCT05232916·Phase 3·Recruiting·Listed Feb 2022
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
for Breast Cancer
Sites in New Haven +78 more locations
Sponsor: BriaCell Therapeutics Corporation
Sex: All·Age: 18+
Code: NCT06072612·Phase 3·Recruiting·Listed Oct 2023
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
for PIK3CA Mutation
Sites in New Haven +51 more locations
Sponsor: Relay Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06982521·Phase 3·Recruiting·Listed May 2025
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
for Breast Neoplasms
Sites in New Haven, Stamford +39 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06312176·Phase 3·Recruiting·Listed Mar 2024
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
for Breast Cancer
Sites in New Haven, North Haven +100 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07062965·Phase 3·Recruiting·Listed Jul 2025
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
for Breast Cancer
Sites in New Haven, North Haven +132 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT06966453·Phase 1, Phase 2·Recruiting·Listed May 2025
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
for Breast Cancer
Drug: Palazestrant
Sites in New Haven +32 more locations
Sponsor: Olema Pharmaceuticals, Inc.
Sex: All·Age: 18+
Code: NCT07085767·Phase 3·Recruiting·Listed Jul 2025
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
for Advanced Solid Tumor
Sites in New Haven +30 more locations
Sponsor: PMV Pharmaceuticals, Inc
Sex: All·Age: 12+
Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
for Advanced Solid Tumor
Sites in New Haven +11 more locations
Sponsor: Daiichi Sankyo
Sex: All·Age: 18+
Code: NCT06172478·Phase 2·Recruiting·Listed Dec 2023
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
for Advanced or Metastatic Solid Tumors
Sites in New Haven +13 more locations
Sponsor: 858 Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06395519·Phase 1, Phase 2·Recruiting·Listed May 2024
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
for Non Small Cell Lung Cancer
Sites in New Haven +23 more locations
Sponsor: SystImmune Inc.
Sex: All·Age: 18+
Code: NCT05983432·Phase 1·Recruiting·Listed Aug 2023
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
for PIK3CA Mutation
Sites in New Haven +22 more locations
Sponsor: Relay Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT05216432·Phase 1·Recruiting·Listed Jan 2022
An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors
for Breast Cancer
Sites in New Haven +5 more locations
Sponsor: BeOne Medicines
Sex: All·Age: 18+
Code: NCT07222267·Phase 1·Recruiting·Listed Oct 2025
Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies
for Breast Cancer
Sites in New Haven +3 more locations
Sponsor: UNC Lineberger Comprehensive Cancer Center
Sex: All·Age: 18+
Code: NCT07340541·Phase 2·Recruiting·Listed Jan 2026
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in New Haven, North Haven +1098 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
ATEMPT 2.0: Adjuvant T-DM1 vs TH
for Breast Cancer
Sites in New Haven, North Haven +44 more locations
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: 18+
Code: NCT04893109·Phase 2·Recruiting·Listed May 2021
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd
for Breast Cancer
Sites in New Haven +9 more locations
Sponsor: Ana C Garrido-Castro, MD
Sex: All·Age: 18+
Code: NCT06533826·Phase 2·Recruiting·Listed Aug 2024
Pre-Operative Window of ET to Inform RT Decisions (POWER II)
for Breast Cancer Female
Sites in New Haven +5 more locations
Sponsor: University of Virginia
Sex: Female·Age: 65+
Code: NCT06507618·Phase 3·Recruiting·Listed Jul 2024
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
for Breast Neoplasms
Sites in New Haven +32 more locations
Sponsor: QuantumLeap Healthcare Collaborative
Sex: All·Age: 18+
Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010
Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy
for Breast Cancer
Drug: Dapagliflozin
1 location in New Haven
Sponsor: Yale University
Sex: Female·Age: 18+
Code: NCT05989347·Phase 1·Recruiting·Listed Aug 2023
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
for Breast Cancer
Drug: Durvalumab
Sites in New Haven +35 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT06103864·Phase 3·Recruiting·Listed Oct 2023
Top Research Study Locations in New Haven
Researchers run research studies in New Haven, CT at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Yale University | Acute Myeloid Leukemia, Alcohol Use Disorder, Stage IV Lung Cancer AJCC v8 | 246 |
| Yale Cancer Center | Advanced Solid Tumor, Advanced Solid Tumors, NSCLC | 67 |
| Yale New Haven Hospital | Ischemic Stroke, Multiple Myeloma, NAFLD | 61 |
| Yale University School of Medicine | Alzheimers Disease, Alzheimers Disease, Familial, Colorectal Cancer | 59 |
| Yale School of Medicine | Epilepsy, Epilepsy (Treatment Refractory), Hemoglobinopathies | 41 |
| Smilow Cancer Center/Yale-New Haven Hospital | Ovarian Carcinoma, Plasma Cell Myeloma, Advanced Hepatocellular Carcinoma | 20 |
| Yale | AML, MDS, Acute Gastrointestinal Bleeding | 12 |
| Yale-New Haven Hospital | Acute Ischemic Stroke, Acute Myeloid Leukemia, Anemia, Sickle Cell | 12 |
| Connecticut Mental Health Center | Borderline Personality Disorder, Alcohol Use, Alcohol Use Disorder | 11 |
| GSK Investigational Site | HIV Infections, Colonic Neoplasms, Gastrointestinal Neoplasms | 8 |
| Smilow Cancer Hospital at Yale New Haven | Advanced Solid Tumor, AML, AML With Mutated NPM1 | 8 |
| Yale Child Study Center | Speech, Anxiety Disorder of Adolescence, Autism | 7 |
| Yale New Haven Health | Chronic Kidney Diseases, Claudication, Critical Limb Ischemia | 7 |
| Musical Intervention Studios | COVID-19, Mental Health Issue, Alzheimer Disease | 6 |
| Smilow Cancer Hospital | Cancer, Sickle Cell Disease, Glioma, Malignant | 6 |
| Yale New Haven Health System | Aortic Stenosis, Heart Failure, ATTR Amyloidosis With Cardiomyopathy | 6 |
| Yale University School Of Medicine | Colorectal Neoplasms, Healthy Volunteers, Irritability Associated With Autism Spectrum Disorder | 6 |
| Yale University, Yale Cancer Center | Breast Cancer, Endometrial Cancer, Ovarian Cancer | 6 |
| BLOOM | COVID-19, Mental Health Issue | 5 |
| Clinical Trial Site | Breast Cancer, ER Positive Breast Cancer, Generalized Myasthenia Gravis | 5 |
| Smilow Cancer Hospital - Yale New Haven Health | Breast Cancer, Esophageal Cancer, Advanced Non-Small Cell Lung Cancer | 5 |
| Yale University Cancer Center | Advanced Solid Tumor, Advanced Solid Tumors, Anal Squamous Cell Carcinoma | 5 |
| Yale New Haven Children's Hospital | Antibiotic Stewardship, Failed or Difficult Intubation, Sequela, Intubation Complication | 4 |
| Yale University Yale Cancer Center | Advanced Solid Tumor, Advanced Solid Tumors, B Cell Lymphoma | 4 |
| Yale-New Haven Hospital-Yale Cancer Center | Advanced Breast Cancer, Breast Cancer, CRC | 4 |
Active & Upcoming Studies in New Haven (2026)
Recruiting trials in New Haven grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (312 active studies)
- Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma · Phase 2 · National Cancer Institute (NCI)
- Unified Network for Integrated Fluid Collection at Yale · Yale University
Neurology & pain (46 active studies)
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
- Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain · Phase 2 · Yale University
Cardiovascular (39 active studies)
- Health-related Benefits of Introducing Table Olives Into the Diet of Young Adults: Olives For Health · Yale University
- Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants · University of Alabama at Birmingham
Diabetes & metabolic (36 active studies)
- Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes · Phase 1 · Yale University
- Glucose, Understanding, Integrated Digital Health, and Engagement (GUIDE) Study · Yale University
Mental health & behavior (26 active studies)
- Real-time Opioid Study · Yale University
- The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease · Phase 2 · Yale University
Vaccines (11 active studies)
HIV / STI (11 active studies)
- A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed · Phase 3 · ViiV Healthcare
- RESTORE Study R61 Phase: Recovery and Engagement for Stimulant Users on Re-entry · University of Texas Southwestern Medical Center
Pediatric (6 active studies)
Common conditions studied in New Haven
- Advanced Solid Tumor (22 active studies)
- Breast Cancer (20 active studies)
- Alcohol Use Disorder (16 active studies)
- Acute Myeloid Leukemia (13 active studies)
- Advanced Solid Tumors (12 active studies)
- Heart Failure (11 active studies)
Leading research sponsors in New Haven
- Yale University
- National Cancer Institute (NCI)
- Children's Oncology Group
- Merck Sharp & Dohme LLC
- SWOG Cancer Research Network
Frequently asked questions
How many paid clinical trials are currently recruiting in New Haven?
There are approximately 848 recruiting clinical trials in New Haven, Connecticut listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in New Haven pay participants?
Most recruiting trials in New Haven compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in New Haven?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in New Haven?
The most common conditions under active study in New Haven include Advanced Solid Tumor (22), Breast Cancer (20), Alcohol Use Disorder (16), Acute Myeloid Leukemia (13), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in New Haven?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in New Haven on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in New Haven?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in New Haven?
Recruiting research sites in New Haven include Yale University, Yale Cancer Center, Yale New Haven Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in New Haven right now?
The largest active categories in New Haven are Cancer & tumors (312), Neurology & pain (46), Cardiovascular (39). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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