Oncology Clinical Trials in Oklahoma City, OK
As of September 2026, 142 paid clinical trials are recruiting for Oncology in Oklahoma City, Oklahoma. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Oklahoma City
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry
144 clinical trials for Oncology
·Clear filters·A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
A Phase 1/1b Study of IAM1363 in HER2 Cancers
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
GEMINI-NSCLC: NSCLC Biomarker Study
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.
Prospective Study to Assess a Diagnostic Aid for Cancer
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
QTX3034 in Patients With KRAS G12D Mutation
A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer
A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors
A Clinical Study of YL205 in Patients With Advanced Solid Tumors
Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
Study of SGR-3515 In Participants With Advanced Solid Tumors.
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.
Study of AVZO-021 in Patients With Advanced Solid Tumors
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
Top Research Study Locations in Oklahoma City
Researchers run research studies in Oklahoma City, OK at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Oklahoma Health Sciences Center | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 185 |
| Mercy Hospital Oklahoma City | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Advanced Lung Non-Small Cell Carcinoma | 47 |
| University of Oklahoma | Endometrial Cancer, Colorectal Cancer, Ovarian Cancer | 26 |
| OU Health Stephenson Cancer Center | Ovarian Cancer, AML With Mutated NPM1, Acute Myeloid Leukemia | 20 |
| Stephenson Cancer Center | Cervical Cancer, Endometrial Cancer, Ovarian Cancer | 13 |
| The University of Oklahoma Health Sciences Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 11 |
| Hightower Clinical | Acute Migraine, Antineutrophil Cytoplasmic Antibody-associated Vasculitis, Cancer | 10 |
| Oklahoma Medical Research Foundation | Systemic Lupus Erythematosus, Aging, Multiple Sclerosis | 10 |
| Sooner Clinical Research | Generalized Anxiety Disorder, Major Depressive Disorder, Autism Spectrum Disorder | 8 |
| TSET Health Promotion Research Center | CRC (Colorectal Cancer), CRC Screening, Smoking Cessation | 8 |
| Oklahoma Heart Hospital | Acute Decompensated Heart Failure, Aortic Stenosis, CHF | 7 |
| Lynn Health Science Institute | Obesity or Overweight, Acne Vulgaris, Hypercholesterolemia | 6 |
| University of Oklahoma Health Campus | Amyloid Pathology, Brain Activity, Brain Aging | 5 |
| University of Oklahoma Health Science Center | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Autoimmune Diseases | 5 |
| Integris Baptist Medical Center | Cardiovascular Diseases, Pulmonary Hypertension, Connective Tissue Diseases | 5 |
| Oklahoma Children's Hospital | Anesthesia, Asthma Attack, Asthma in Children | 4 |
| Oklahoma Proton Center | Breast Cancer, Breast Neoplasm, Breast Tumor | 4 |
| Unity Clinical Research | Atopic Dermatitis, Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa | 4 |
| University of Oklahoma Health Sciences | Acute Respiratory Distress Syndrome, Cancer Survivorship, Chemotherapy Side Effects | 4 |
| Digestive Disease Specialists Inc | Crohn Disease, Colitis, Ulcerative | 3 |
| GSK Investigational Site | Asthma, Alzheimer's Disease | 3 |
| Integris Cancer Institute of Oklahoma | Stage IIIB Lung Cancer AJCC v8, Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Lung Non-Small Cell Carcinoma | 3 |
| Integris Southwest Medical Center | Previously Treated Non-Small Cell Lung Cancer, Recurrent Lung Non-Small Cell Carcinoma, Stage III Colon Cancer | 3 |
| OU Health University of Oklahoma Medical Center | Acquired Antithrombin Deficiency, Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer | 3 |
| Oklahoma University Health Sciences Center | Advanced Solid Tumors, Colorectal Cancer, Inflammation | 3 |
Active & Upcoming Studies in Oklahoma City (2026)
Recruiting trials in Oklahoma City grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (249 active studies)
- Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial · Phase 3 · National Cancer Institute (NCI)
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
Cardiovascular (39 active studies)
Diabetes & metabolic (27 active studies)
- Disulfiram in Rheumatoid Arthritis · Phase 2 · University of Oklahoma
- Impact of Chia Seeds on Human Breast Milk Composition · University of Oklahoma
Mental health & behavior (23 active studies)
- Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation · Phase 2 · University of Oklahoma
Neurology & pain (23 active studies)
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Pediatric (6 active studies)
- Supraglottic Airway for Resuscitation Trial · Children's Hospital of Philadelphia
- iAmHealthy Clinical Practice Guideline (CPG) · University of Kansas Medical Center
Eye & vision (3 active studies)
- Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant · Phase 2, Phase 3 · Glaukos Corporation
- A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma · Phase 3 · AbbVie
Vaccines (2 active studies)
- Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children · Phase 3 · University of Alabama at Birmingham
- Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study · Phase 3 · Ansun Biopharma, Inc.
Common conditions studied in Oklahoma City
- Endometrial Cancer (17 active studies)
- Ovarian Cancer (14 active studies)
- Acute Myeloid Leukemia (13 active studies)
- Malignant Solid Neoplasm (10 active studies)
- Breast Cancer (9 active studies)
- Major Depressive Disorder (9 active studies)
Leading research sponsors in Oklahoma City
- University of Oklahoma
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- SWOG Cancer Research Network
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Oklahoma City?
There are approximately 594 recruiting clinical trials in Oklahoma City, Oklahoma listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Oklahoma City pay participants?
Most recruiting trials in Oklahoma City compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Oklahoma City?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Oklahoma City?
The most common conditions under active study in Oklahoma City include Endometrial Cancer (17), Ovarian Cancer (14), Acute Myeloid Leukemia (13), Malignant Solid Neoplasm (10), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Oklahoma City?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Oklahoma City on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Oklahoma City?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Oklahoma City?
Recruiting research sites in Oklahoma City include University of Oklahoma Health Sciences Center, Mercy Hospital Oklahoma City, University of Oklahoma, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Oklahoma City right now?
The largest active categories in Oklahoma City are Cancer & tumors (249), Cardiovascular (39), Diabetes & metabolic (27). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.