Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry | NCT07732686

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Conditions

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Accepted

Interventions

Proton Transfer Reaction Mass Spectrometry Analysis — DEVICE
This is a noninvasive intervention. Participants will be asked to provide a breath sample using a disposable mouthpiece equipped with a saliva/moisture trap and a non-rebreathing valve. Breath samples will be collected through normal, steady exhalation. The entire breath collection process is expected to take no more than 30 minutes to complete.

Study Details

The purpose of this clinical trial is to evaluate whether volatile organic compound (VOC) signatures detected in the breath of patients with cancer can serve as a potential screening tool for the early detection of cancer.

Key Dates

First listed: Jul 29, 2026
Start date: Oct 31, 2026
Status verified: Jul 2026
Primary completion: Oct 31, 2027
Completion: Oct 31, 2029

Study Design

Enrollment: 2,000 participants (estimated)

Arms

Arm: Diagnosed Malignancies
Participants in this group either have a newly diagnosed, untreated cancer or a pre-existing cancer diagnosis but are not currently receiving anticancer therapy. Participants with a pre-existing diagnosis must not have received any anticancer treatment within the previous month.
Arm: Healthy Control Group
Participants in this control group have no current or prior diagnosis of a malignancy.