Oncology Clinical Trials in Philadelphia, PA

As of September 2026, 376 paid clinical trials are recruiting for Oncology in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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377 clinical trials for Oncology

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Philadelphia, Allentown +141 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

Sites in Philadelphia, Pittsburgh +44 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting·Listed May 2021

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PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

for Cervical Cancer

Sites in Philadelphia, Lancaster +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05758688·Phase 2·Recruiting·Listed Mar 2023

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A Study of Tarlatamab for People With Prostate Cancer

for Metastatic Prostate Cancer

Drug: Tarlatamab

Sites in Philadelphia +9 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Male·Age: 18+

Code: NCT07111507·Phase 2·Recruiting·Listed Aug 2025

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Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

for Gastric Adenocarcinoma

Sites in Philadelphia, Pittsburgh +76 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT07001748·Phase 2, Phase 3·Recruiting·Listed Jun 2025

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

Sites in Philadelphia, Pittsburgh +40 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

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Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

Sites in Philadelphia +11 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting·Listed May 2023

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

Sites in Philadelphia +18 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting·Listed Oct 2023

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Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

Drug: Cabozantinib

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1·Recruiting·Listed Dec 2023

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Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

for Metastatic Breast Cancer

Sites in Philadelphia +3 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT05964504·Recruiting·Listed Jul 2023

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Gemcitabine and Carboplatin After Progression on Enfortumab Vedotin and Pembrolizumab in Advanced/Metastatic Urothelial Carcinoma

for Urothelial Carcinoma

2 locations in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT07043972·Phase 2·Recruiting·Listed Jun 2025

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

Sites in Philadelphia +12 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting·Listed Oct 2021

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Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Philadelphia, Hershey +69 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06686771·Phase 3·Recruiting·Listed Nov 2024

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Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

for Glioma

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 - 21

Code: NCT05555550·EARLY_Phase 1·Recruiting·Listed Sep 2022

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Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

for Gastric Cancer

Sites in Philadelphia +2 more locations

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05274048·Phase 1·Recruiting·Listed Mar 2022

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Philadelphia +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

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A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

for Acute Myeloid Leukemia Post Cytotoxic Therapy

Sites in Philadelphia, Pittsburgh +10 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT07012044·Phase 1·Recruiting·Listed Jun 2025

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Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

for Glioblastoma

2 locations in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06613841·EARLY_Phase 1·Recruiting·Listed Sep 2024

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Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

for Refractory Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Philadelphia +9 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 30

Code: NCT06177067·Phase 1·Recruiting·Listed Dec 2023

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Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

for Breast Cancer

Sites in Philadelphia +3 more locations

Sponsor: University Hospital, Basel, Switzerland

Sex: All·Age: 18+

Code: NCT07140172·Recruiting·Listed Aug 2025

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Philadelphia, Hershey +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

for Breast Cancer

Sites in Philadelphia +10 more locations

Sponsor: American College of Radiology

Sex: Female·Age: 45 - 74·Accepts healthy volunteers

Code: NCT05625659·Recruiting·Listed Nov 2022

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Lurbinectedin in FET-Fused Tumors

for Ewing Sarcoma

Drug: Lurbinectedin

Sites in Philadelphia +5 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10+

Code: NCT05918640·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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Time Restricted Eating for the Improvement of Outcomes in Patients With Stage I-III Breast Cancer Receiving Chemotherapy Before Surgery

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Philadelphia, Willow Grove +3 more locations

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05327608·Recruiting·Listed Apr 2022

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IMmunotherapy: Prospective Assessment of Cannabis Treatment in Cancer

for Cancer

Sites in Philadelphia +1 more location

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT06206941·Recruiting·Listed Jan 2024

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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

Sites in Philadelphia, Pittsburgh +17 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting·Listed Apr 2021

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PENN-Surveillance Markers of Utility for Recurrence After (Neo)Adjuvant Therapy for Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT02732171·Recruiting·Listed Apr 2016

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Sites in Philadelphia, Willow Grove +167 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06992427·Phase 3·Recruiting·Listed May 2025

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Window Study of Intratumoral Mitazalimab in Breast Cancer (WINIT-BC)

for Breast Cancer

1 location in Philadelphia

Sponsor: Jennifer Zhang

Sex: All·Age: 18+

Code: NCT07319195·EARLY_Phase 1·Recruiting·Listed Jan 2026

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Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

for High Grade Glioma

Sites in Philadelphia +2 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 4 - 39

Code: NCT05278208·Phase 1, Phase 2·Recruiting·Listed Mar 2022

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NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

for Neuroblastoma

Drug: Irinotecan

Sites in Philadelphia +12 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 31

Code: NCT06450041·Phase 2·Recruiting·Listed Jun 2024

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

Sites in Philadelphia, Allentown +39 more locations

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting·Listed Feb 2022

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Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

for AIDS-Related Diffuse Large B-cell Lymphoma

Sites in Philadelphia +6 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05077527·Phase 1·Recruiting·Listed Oct 2021

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Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors

for Metastatic Renal Cell Carcinoma

Drug: Cabozantinib

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05263050·Phase 2·Recruiting·Listed Mar 2022

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Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma

for Renal Cell Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05733715·EARLY_Phase 1·Recruiting·Listed Feb 2023

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Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)

for Differentiated Thyroid Cancer

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 2 - 25

Code: NCT06458036·Phase 2·Recruiting·Listed Jun 2024

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Childhood Cancer Survivor Study

for Cancer

Sites in Philadelphia, Pittsburgh +25 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01120353·Recruiting·Listed May 2010

Apply to this trial

Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

for Gynecologic Cancers

Sites in Philadelphia +2 more locations

Sponsor: Oregon State University

Sex: Female·Age: 18+

Code: NCT07055854·Phase 1·Recruiting·Listed Jul 2025

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Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

for Hematopoietic and Lymphoid Cell Neoplasm

Sites in Philadelphia, Chadds Ford +392 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: All ages

Code: NCT04242095·Recruiting·Listed Jan 2020

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Evaluation of Grief Therapy Approaches for Bereaved Parents

for Grief

Sites in Philadelphia +4 more locations

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT05142605·Recruiting·Listed Dec 2021

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Conditions in Oncology (Philadelphia, PA)

Solid tumor· 57 Breast cancer· 44 Non-small cell lung cancer (NSCLC)· 36 Cancer (any)· 36 Colorectal cancer· 27 Ovarian cancer· 26 Prostate cancer· 24 Acute myeloid leukemia (AML)· 24 Pancreatic cancer· 21 Endometrial cancer· 18 Non-Hodgkin lymphoma· 18 Head and neck cancer· 16 Gastric cancer· 15 Bladder cancer· 14 Hematologic malignancy· 13 Glioma· 12 Multiple myeloma· 12 Diffuse large B-cell lymphoma (DLBCL)· 12 Esophageal cancer· 10 Myelodysplastic syndromes (MDS)· 10 Lung cancer· 9 Liver cancer· 9 Metastatic prostate cancer· 9 Kidney cancer· 9 Leukemia (other)· 9 Fallopian tube cancer· 8 Melanoma· 8 Neuroblastoma· 8 Pediatric cancer· 8 Cervical cancer· 7 Chronic lymphocytic leukemia (CLL)· 7 Neuroendocrine tumors· 7 Metastatic breast cancer· 6 Triple-negative breast cancer· 6 Biliary tract cancer· 6 Glioblastoma· 6 Hodgkin lymphoma· 6 Ewing sarcoma· 6 Osteosarcoma· 5 Gastroesophageal junction cancer· 4 Acute lymphoblastic leukemia· 4 Myelofibrosis· 4 Small lymphocytic lymphoma· 4 HER2-positive breast cancer· 3 HER2-negative breast cancer· 3 Small cell lung cancer· 3 Myeloproliferative neoplasm· 3 Follicular lymphoma· 3 Burkitt lymphoma· 3 Thyroid cancer· 3 Rhabdomyosarcoma· 3 Gastrointestinal cancer· 2 Uterine cancer· 2 Brain cancer· 2 Mantle cell lymphoma· 2 Marginal zone lymphoma· 2 Soft tissue sarcoma· 2 Metastatic colorectal cancer· 1 Chronic myelomonocytic leukemia· 1 Skin cancer· 1 Sarcoma· 1 Mesothelioma· 1