Solid tumor Clinical Trials in Philadelphia, PA
As of August 2026, 56 paid clinical trials are recruiting for Solid tumor in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Related specialties in Philadelphia
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56 clinical trials for Solid tumor
·Clear filters·Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
A Study of ZL-1310 in Participants With Selected Solid Tumors
A Study of PYX-201 in Advanced Solid Tumors
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors
A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
Study of AVZO-021 in Patients With Advanced Solid Tumors
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours
A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors
A Phase I Study of ROSE12 Alone and in Combination With Other Anti-tumor Agents in Patients With Solid Tumors
SNV1521 in Participants With Advanced Solid Tumors
Study to Evaluate IMGS-001 Treatment in Patients With Relapsed or Refractory Advanced Solid Tumors
Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors
Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors
Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors
SNV4818 in Participants With Advanced Solid Tumors
S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors
Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Top Research Study Locations in Philadelphia
Researchers run research studies in Philadelphia, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pennsylvania | Heart Failure, Opioid Use Disorder, Colorectal Cancer | 358 |
| Children's Hospital of Philadelphia | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, Pediatric Cancer | 302 |
| Thomas Jefferson University Hospital | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 110 |
| Thomas Jefferson University | Focal Epilepsy, Advanced Melanoma, Cancer | 97 |
| Fox Chase Cancer Center | Breast Cancer, Cancer, Urothelial Carcinoma | 95 |
| Hospital of the University of Pennsylvania | Abdominal Aortic Aneurysm, Breast Cancer, Aortic Dissection | 87 |
| Temple University | Amyotrophic Lateral Sclerosis, COPD, Emphysema | 41 |
| The Children's Hospital of Philadelphia | Mitochondrial Diseases, Primary Mitochondrial Disease, 4H Syndrome | 40 |
| Temple University Hospital | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, COPD | 35 |
| University of Pennsylvania/Abramson Cancer Center | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 31 |
| Pennsylvania Hospital | Stroke, Acute, Activity Restriction, Advanced Cancer | 28 |
| Penn Presbyterian Medical Center | Atrial Fibrillation, Heart Failure, ADHF | 26 |
| Abramson Cancer Center of the University of Pennsylvania | Breast Cancer, Advanced Solid Tumor, DLBCL - Diffuse Large B Cell Lymphoma | 25 |
| Jefferson Torresdale Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | 23 |
| Saint Christopher's Hospital for Children | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 22 |
| Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA | Parkinson Disease, Stress Disorders, Post-Traumatic, Alcohol Use Disorder | 18 |
| Sidney Kimmel Cancer Center at Thomas Jefferson University | Breast Cancer, Colorectal Cancer, Hormone Receptor Positive Breast Carcinoma | 16 |
| Drexel University | Autism Spectrum Disorder, Obesity, Anxiety | 13 |
| Penn Medicine | Hypertension, ALS, Allogeneic Transplantation | 13 |
| University of Pennsylvania Hospital | Chronic Lymphocytic Leukemia, Neoplasm Metastasis, Non-Hodgkin Lymphoma | 13 |
| GSK Investigational Site | Asthma, Connective Tissue Diseases, Gastrointestinal Neoplasms | 12 |
| Childrens Hospital of Philadelphia | Suicide, Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR) | 12 |
| University of Pennsylvania, Abramson Cancer Center | Advanced Solid Tumor, Biliary Tract Cancer, Breast Cancer | 12 |
| Abramson Cancer Center at University of Pennsylvania | Cardiotoxicity, Renal Cell Carcinoma, AML, Adult | 10 |
| Thomas Jefferson University, Sidney Kimmel Cancer Center | Advanced Solid Tumor, Colorectal Cancer, Bladder Cancer | 10 |
Active & Upcoming Studies in Philadelphia (2026)
Recruiting trials in Philadelphia grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (556 active studies)
- Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment · Phase 1, Phase 2 · National Cancer Institute (NCI)
- The AYA Oncology Self-care Movement · Northwestern University
Neurology & pain (111 active studies)
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
- Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease · Phase 4 · VA Office of Research and Development
Cardiovascular (110 active studies)
- UNDERSTANDING THE EFFECTS OF PULMONARY ARTERIAL HYPERPTENSION ON LEAN MUSCLE MASS-SUBSTUDY · University of Pennsylvania
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF · Phase 3 · AstraZeneca
Diabetes & metabolic (65 active studies)
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities · Phase 3 · Ascletis Pharma (China) Co., Limited
Mental health & behavior (49 active studies)
- NST-SPARK Open-Label Phase 1 STTR (IGNITE) · North Shore Therapeutics, Inc.
- Effect of cTBS on Startle and TMS-evoked BOLD · University of Pennsylvania
Pediatric (47 active studies)
- Bilevel Positive Airway Pressure (BPAP) for Severe Asthma · Columbia University
- Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). · Phase 2 · BrainChild Bio, Inc
HIV / STI (27 active studies)
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Eye & vision (23 active studies)
- Penn SICCA Follow-up Study · University of Pennsylvania
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME) · Phase 1 · Genentech, Inc.
Vaccines (7 active studies)
- Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older · Phase 1, Phase 2 · Sanofi
- Flu Infection at UPHS · University of Pennsylvania
Common conditions studied in Philadelphia
- Breast Cancer (36 active studies)
- Cancer (25 active studies)
- Heart Failure (21 active studies)
- Ovarian Cancer (21 active studies)
- Prostate Cancer (21 active studies)
- Advanced Solid Tumor (18 active studies)
Leading research sponsors in Philadelphia
- University of Pennsylvania
- Abramson Cancer Center at Penn Medicine
- Children's Hospital of Philadelphia
- Thomas Jefferson University
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Philadelphia?
There are approximately 1,986 recruiting clinical trials in Philadelphia, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Philadelphia pay participants?
Most recruiting trials in Philadelphia compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Philadelphia?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Philadelphia?
The most common conditions under active study in Philadelphia include Breast Cancer (36), Cancer (25), Heart Failure (21), Ovarian Cancer (21), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Philadelphia?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Philadelphia on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Philadelphia?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Philadelphia?
Recruiting research sites in Philadelphia include University of Pennsylvania, Children's Hospital of Philadelphia, Thomas Jefferson University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Philadelphia right now?
The largest active categories in Philadelphia are Cancer & tumors (556), Neurology & pain (111), Cardiovascular (110). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.