Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia
for Hormone Receptor Positive Breast Carcinoma
1 location in Philadelphia
Sponsor: Thomas Jefferson University
Sex: Female·Age: 18+
Code: NCT07737951·Recruiting·Listed Jul 30, 2026
Breast cancer Clinical Trials in Philadelphia, PA
As of August 2026, 40 paid clinical trials are recruiting for Breast cancer in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Philadelphia
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
41 clinical trials for Breast cancer
·Clear filters· Email me when a new breast cancer trial opens in Philadelphia, PA.
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
for Breast Neoplasms
Sites in Philadelphia, Willow Grove +123 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07174336·Phase 3·Recruiting·Listed Sep 2025
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
for Breast Cancer
Sites in Philadelphia, Wynnewood +170 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06492616·Phase 3·Recruiting·Listed Jul 2024
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
for Breast Cancer
Sites in Philadelphia, Meadowbrook +47 more locations
Sponsor: Greenwich LifeSciences, Inc.
Sex: All·Age: 18 - 100
Code: NCT05232916·Phase 3·Recruiting·Listed Feb 2022
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
for Breast Neoplasms
Sites in Philadelphia +40 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06312176·Phase 3·Recruiting·Listed Mar 2024
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
for Breast Neoplasms
Sites in Philadelphia, Allentown +36 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT06926868·Phase 2, Phase 3·Recruiting·Listed Apr 2025
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
for Advanced Solid Tumor
Sites in Philadelphia, York +29 more locations
Sponsor: PMV Pharmaceuticals, Inc
Sex: All·Age: 12+
Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
for Bladder Carcinoma
Sites in Philadelphia, York +25 more locations
Sponsor: Guardant Health, Inc.
Sex: All·Age: 18+
Code: NCT05059444·Recruiting·Listed Sep 2021
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
for Cancer, Metastatic
Sites in Philadelphia +66 more locations
Sponsor: Massive Bio, Inc.
Sex: All·Age: All ages
Code: NCT03452774·Recruiting·Listed Mar 2018
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
for Ovarian Neoplasms
Sites in Philadelphia +18 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07213791·Phase 1·Recruiting·Listed Oct 2025
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
for Breast Cancer
Drug: Giredestrant
Sites in Philadelphia, Hershey +24 more locations
Sponsor: Genentech, Inc.
Sex: All·Age: 18+
Code: NCT07100106·Phase 1, Phase 2·Recruiting·Listed Aug 2025
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
for Ovarian Cancer
Sites in Philadelphia, Pittsburgh +11 more locations
Sponsor: NextCure, Inc.
Sex: All·Age: 18+
Code: NCT06774963·Phase 1·Recruiting·Listed Jan 2025
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
for Breast Cancer
Sites in Philadelphia +21 more locations
Sponsor: Celcuity Inc
Sex: All·Age: 18+
Code: NCT06757634·Phase 3·Recruiting·Listed Jan 2025
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
for Advanced or Metastatic Solid Tumors
Sites in Philadelphia +13 more locations
Sponsor: 858 Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06395519·Phase 1, Phase 2·Recruiting·Listed May 2024
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
for Advanced Solid Tumor
Sites in Philadelphia +20 more locations
Sponsor: Clasp Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06778863·Phase 1·Recruiting·Listed Jan 2025
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
for Non-Small Cell Lung Cancer
Sites in Philadelphia +4 more locations
Sponsor: Fate Therapeutics
Sex: All·Age: 18+
Code: NCT07216105·Phase 1·Recruiting·Listed Oct 2025
Identification of Breast Cancer in Breath Samples Using Trained Detection Dogs
for Breast Cancer
Sites in Philadelphia +1 more location
Sponsor: SpotitEarly
Sex: Female·Age: 18+·Accepts healthy volunteers
Code: NCT07038785·Recruiting·Listed Jun 2025
A Mixed-Methods Metabolomics Investigation of Lifestyle and Energy Balance During Breast Cancer Survivorship
for Breast Cancer
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: Female·Age: 18+
Code: NCT07655934·Recruiting·Listed Jun 2026
EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients
for Breast Cancer
1 location in Philadelphia
Sponsor: Thomas Jefferson University
Sex: Female·Age: 18+
Code: NCT07478016·Recruiting·Listed Mar 2026
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Philadelphia, Wynnewood +1098 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Window Study of Intratumoral Mitazalimab in Breast Cancer (WINIT-BC)
for Breast Cancer
1 location in Philadelphia
Sponsor: Jennifer Zhang
Sex: All·Age: 18+
Code: NCT07319195·EARLY_Phase 1·Recruiting·Listed Jan 2026
ATEMPT 2.0: Adjuvant T-DM1 vs TH
for Breast Cancer
Sites in Philadelphia, Pittsburgh +44 more locations
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: 18+
Code: NCT04893109·Phase 2·Recruiting·Listed May 2021
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
for Breast Cancer
Sites in Philadelphia +3 more locations
Sponsor: University Hospital, Basel, Switzerland
Sex: All·Age: 18+
Code: NCT07140172·Recruiting·Listed Aug 2025
Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
for Breast Cancer
Sites in Philadelphia +10 more locations
Sponsor: American College of Radiology
Sex: Female·Age: 45 - 74·Accepts healthy volunteers
Code: NCT05625659·Recruiting·Listed Nov 2022
PENN-Surveillance Markers of Utility for Recurrence After (Neo)Adjuvant Therapy for Breast Cancer
for Breast Cancer
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT02732171·Recruiting·Listed Apr 2016
Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors
for Gynecologic Cancers
Sites in Philadelphia +2 more locations
Sponsor: Oregon State University
Sex: Female·Age: 18+
Code: NCT07055854·Phase 1·Recruiting·Listed Jul 2025
Neoadjuvant Breast Cancer Time Restricted Eating
for Anatomic Stage I Breast Cancer AJCC v8
1 location in Philadelphia
Sponsor: Thomas Jefferson University
Sex: All·Age: 18+
Code: NCT05327608·Phase 2·Recruiting·Listed Apr 2022
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
for Breast Neoplasms
Sites in Philadelphia +32 more locations
Sponsor: QuantumLeap Healthcare Collaborative
Sex: All·Age: 18+
Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010
ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer
for Breast Cancer
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT04523857·Phase 2·Recruiting·Listed Aug 2020
Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC
for Breast Cancer
Sites in Philadelphia +14 more locations
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: 18+
Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020
Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)
for Breast Cancer
Drug: Atezolizumab
Sites in Philadelphia +3 more locations
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: 18+
Code: NCT04434040·Phase 2·Recruiting·Listed Jun 2020
Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer
for Breast Cancer
Sites in Philadelphia +6 more locations
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT04841148·Phase 2·Recruiting·Listed Apr 2021
FES BPET-DBT in Newly Diagnosed Breast Cancer
for Breast Cancer
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: Female·Age: 18+
Code: NCT05659797·EARLY_Phase 1·Recruiting·Listed Dec 2022
Safe and Explainable AI
for Artifical Inteligence
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT06694181·Recruiting·Listed Nov 2024
CTNNA1 Familial Expansion Study
for Cancer Gene Mutation
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT05126290·Recruiting·Listed Nov 2021
Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer
for Anatomic Stage 0 Breast Cancer AJCC v8
1 location in Philadelphia
Sponsor: Thomas Jefferson University
Sex: All·Age: 40+
Code: NCT04959474·Recruiting·Listed Jul 2021
[18F] F-GLN by PET/CT in Breast Cancer
for Breast Cancer
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT03863457·Phase 1·Recruiting·Listed Mar 2019
Surviving Daily Life
for Stress
1 location in Philadelphia
Sponsor: Thomas Jefferson University
Sex: Female·Age: 40+
Code: NCT07054723·Recruiting·Listed Jul 2025
Prospective Breast Cancer Biospecimen Collection
for Breast Cancer
1 location in Philadelphia
Sponsor: Thomas Jefferson University
Sex: All·Age: 18+
Code: NCT04074720·Recruiting·Listed Aug 2019
Role of the Immune Environment in Response to Therapy in Breast Cancer
for Breast Cancer
1 location in Philadelphia
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: Female·Age: 18+
Code: NCT05396612·Recruiting·Listed May 2022
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
for Advanced Solid Tumor
Sites in Philadelphia +7 more locations
Sponsor: MOMA Therapeutics
Sex: All·Age: 18+
Code: NCT06545942·Phase 1·Recruiting·Listed Aug 2024
Top Research Study Locations in Philadelphia
Researchers run research studies in Philadelphia, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pennsylvania | Heart Failure, Opioid Use Disorder, Colorectal Cancer | 358 |
| Children's Hospital of Philadelphia | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, Pediatric Cancer | 302 |
| Thomas Jefferson University Hospital | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 110 |
| Thomas Jefferson University | Focal Epilepsy, Advanced Melanoma, Cancer | 97 |
| Fox Chase Cancer Center | Breast Cancer, Cancer, Urothelial Carcinoma | 95 |
| Hospital of the University of Pennsylvania | Abdominal Aortic Aneurysm, Breast Cancer, Aortic Dissection | 87 |
| Temple University | Amyotrophic Lateral Sclerosis, COPD, Emphysema | 41 |
| The Children's Hospital of Philadelphia | Mitochondrial Diseases, Primary Mitochondrial Disease, 4H Syndrome | 40 |
| Temple University Hospital | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, COPD | 35 |
| University of Pennsylvania/Abramson Cancer Center | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 31 |
| Pennsylvania Hospital | Stroke, Acute, Activity Restriction, Advanced Cancer | 28 |
| Penn Presbyterian Medical Center | Atrial Fibrillation, Heart Failure, ADHF | 26 |
| Abramson Cancer Center of the University of Pennsylvania | Breast Cancer, Advanced Solid Tumor, DLBCL - Diffuse Large B Cell Lymphoma | 25 |
| Jefferson Torresdale Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | 23 |
| Saint Christopher's Hospital for Children | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 22 |
| Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA | Parkinson Disease, Stress Disorders, Post-Traumatic, Alcohol Use Disorder | 18 |
| Sidney Kimmel Cancer Center at Thomas Jefferson University | Breast Cancer, Colorectal Cancer, Hormone Receptor Positive Breast Carcinoma | 16 |
| Drexel University | Autism Spectrum Disorder, Obesity, Anxiety | 13 |
| Penn Medicine | Hypertension, ALS, Allogeneic Transplantation | 13 |
| University of Pennsylvania Hospital | Chronic Lymphocytic Leukemia, Neoplasm Metastasis, Non-Hodgkin Lymphoma | 13 |
| GSK Investigational Site | Asthma, Connective Tissue Diseases, Gastrointestinal Neoplasms | 12 |
| Childrens Hospital of Philadelphia | Suicide, Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR) | 12 |
| University of Pennsylvania, Abramson Cancer Center | Advanced Solid Tumor, Biliary Tract Cancer, Breast Cancer | 12 |
| Abramson Cancer Center at University of Pennsylvania | Cardiotoxicity, Renal Cell Carcinoma, AML, Adult | 10 |
| Thomas Jefferson University, Sidney Kimmel Cancer Center | Advanced Solid Tumor, Colorectal Cancer, Bladder Cancer | 10 |
Active & Upcoming Studies in Philadelphia (2026)
Recruiting trials in Philadelphia grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (556 active studies)
- Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment · Phase 1, Phase 2 · National Cancer Institute (NCI)
- The AYA Oncology Self-care Movement · Northwestern University
Neurology & pain (111 active studies)
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
- Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease · Phase 4 · VA Office of Research and Development
Cardiovascular (110 active studies)
- UNDERSTANDING THE EFFECTS OF PULMONARY ARTERIAL HYPERPTENSION ON LEAN MUSCLE MASS-SUBSTUDY · University of Pennsylvania
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF · Phase 3 · AstraZeneca
Diabetes & metabolic (65 active studies)
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities · Phase 3 · Ascletis Pharma (China) Co., Limited
Mental health & behavior (49 active studies)
- NST-SPARK Open-Label Phase 1 STTR (IGNITE) · North Shore Therapeutics, Inc.
- Effect of cTBS on Startle and TMS-evoked BOLD · University of Pennsylvania
Pediatric (47 active studies)
- Bilevel Positive Airway Pressure (BPAP) for Severe Asthma · Columbia University
- Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). · Phase 2 · BrainChild Bio, Inc
HIV / STI (27 active studies)
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Eye & vision (23 active studies)
- Penn SICCA Follow-up Study · University of Pennsylvania
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME) · Phase 1 · Genentech, Inc.
Vaccines (7 active studies)
- Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older · Phase 1, Phase 2 · Sanofi
- Flu Infection at UPHS · University of Pennsylvania
Common conditions studied in Philadelphia
- Breast Cancer (36 active studies)
- Cancer (25 active studies)
- Heart Failure (21 active studies)
- Ovarian Cancer (21 active studies)
- Prostate Cancer (21 active studies)
- Advanced Solid Tumor (18 active studies)
Leading research sponsors in Philadelphia
- University of Pennsylvania
- Abramson Cancer Center at Penn Medicine
- Children's Hospital of Philadelphia
- Thomas Jefferson University
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Philadelphia?
There are approximately 1,986 recruiting clinical trials in Philadelphia, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Philadelphia pay participants?
Most recruiting trials in Philadelphia compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Philadelphia?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Philadelphia?
The most common conditions under active study in Philadelphia include Breast Cancer (36), Cancer (25), Heart Failure (21), Ovarian Cancer (21), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Philadelphia?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Philadelphia on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Philadelphia?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Philadelphia?
Recruiting research sites in Philadelphia include University of Pennsylvania, Children's Hospital of Philadelphia, Thomas Jefferson University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Philadelphia right now?
The largest active categories in Philadelphia are Cancer & tumors (556), Neurology & pain (111), Cardiovascular (110). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
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