Oncology Clinical Trials in Philadelphia, PA

As of September 2026, 376 paid clinical trials are recruiting for Oncology in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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377 clinical trials for Oncology

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

Sites in Philadelphia +10 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting·Listed May 2023

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Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

for Breast Cancer

Drug: Atezolizumab

Sites in Philadelphia +3 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04434040·Phase 2·Recruiting·Listed Jun 2020

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Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

for Esophageal Adenocarcinoma

Sites in Philadelphia +1 more location

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06340711·Phase 2·Recruiting·Listed Apr 2024

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Neuroblastoma Biology Study

for Neuroblastoma

Sites in Philadelphia +13 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 31 Days - 99

Code: NCT01587300·Recruiting·Listed Apr 2012

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Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05842174·Phase 1, Phase 2·Recruiting·Listed May 2023

Apply to this trial

Massage Impact on Sleep in Pediatric Oncology

for Cancer

Sites in Philadelphia +1 more location

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 12 - 21

Code: NCT06892158·Recruiting·Listed Mar 2025

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A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

Sites in Philadelphia +8 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting·Listed Dec 2020

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Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

for Leukemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 25

Code: NCT06839456·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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Re-Engaging AYA Survivors in Cancer-Related Healthcare

for Cancer

Sites in Philadelphia +2 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 15 - 29

Code: NCT07138040·Recruiting·Listed Aug 2025

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Collection of Circulating Biomarkers in Pancreatic Cancer

for Pancreas Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05743049·Recruiting·Listed Feb 2023

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Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction

for Malignant Solid Neoplasm

Sites in Philadelphia +1 more location

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06306638·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for Pancreatic Ductal Adenocarcinoma

Sites in Philadelphia +4 more locations

Sponsor: Gulam Manji

Sex: All·Age: 18+

Code: NCT06048484·Phase 2·Recruiting·Listed Sep 2023

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Tazemetostat and Palbociclib With CPX-351for R/R AML

for Recurrent Acute Myeloid Leukemia

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05627232·Phase 1·Recruiting·Listed Nov 2022

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FES BPET-DBT in Newly Diagnosed Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05659797·EARLY_Phase 1·Recruiting·Listed Dec 2022

Apply to this trial

Safe and Explainable AI

for Artifical Inteligence

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06694181·Recruiting·Listed Nov 2024

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Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC

for Leukemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 30

Code: NCT02356653·EARLY_Phase 1·Recruiting·Listed Feb 2015

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All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for Glioma

1 location in Philadelphia

Sponsor: Stephen Bagley, MD, MSCE

Sex: All·Age: 18+

Code: NCT05345002·Phase 2·Recruiting·Listed Apr 2022

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SBRT With Atezo/Bev for HCC

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18 - 99

Code: NCT05488522·Phase 1·Recruiting·Listed Aug 2022

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Virtual Reality 3D-Surgery Modeling to Enhance Head and Neck Cancer Surgery Quality

for Head and Neck Squamous Cell Carcinoma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05031910·Recruiting·Listed Sep 2021

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Contrast-Enhanced Ultrasound Imaging for Diagnosing Recurrent Renal Cell Carcinoma (RCC) Post Ablation

for Recurrent Renal Cell Carcinoma

1 location in Philadelphia

Sponsor: john eisenbrey

Sex: All·Age: 18+

Code: NCT05641935·Phase 2·Recruiting·Listed Dec 2022

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Healthy Volunteers Study

for Ovarian Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 30 - 50·Accepts healthy volunteers

Code: NCT06962059·Recruiting·Listed May 2025

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Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma

for Neuroblastoma

Sites in Philadelphia +5 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: Up to 17

Code: NCT06831552·Recruiting·Listed Feb 2025

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PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial

for Lung Carcinoma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05775939·Recruiting·Listed Mar 2023

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Hypofractionated WPPT With HDR Boost

for Prostate Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06591819·Phase 2·Recruiting·Listed Sep 2024

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Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

for Pancreatic Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT02478892·Recruiting·Listed Jun 2015

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CTNNA1 Familial Expansion Study

for Cancer Gene Mutation

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05126290·Recruiting·Listed Nov 2021

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Empathic Communication Skills (ECS) Training

for Lung Cancer

Sites in Philadelphia +7 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05456841·Recruiting·Listed Jul 2022

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Mozobil for Autologous Hematopoietic Stem Cell Transplantation

for Multiple Myeloma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07188090·Phase 2·Recruiting·Listed Sep 2025

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TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

for BRCA1 Gene Mutation

Sites in Philadelphia +10 more locations

Sponsor: University Medical Center Nijmegen

Sex: Female·Age: 25 - 50

Code: NCT04294927·Recruiting·Listed Mar 2020

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Targeted Therapy to Increase RAI Uptake in Metastatic DTC

for Papillary Thyroid Cancer

Sites in Philadelphia +7 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0+

Code: NCT05024929·Recruiting·Listed Aug 2021

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Home Blood Transfusions

for Hematologic Malignancy

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07121140·Recruiting·Listed Aug 2025

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Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

for Anatomic Stage 0 Breast Cancer AJCC v8

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 40+

Code: NCT04959474·Recruiting·Listed Jul 2021

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The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer

for Lung Non-Small Cell Carcinoma

Sites in Philadelphia, Willow Grove & Abington

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05502523·Recruiting·Listed Aug 2022

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[18F] F-GLN by PET/CT in Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT03863457·Phase 1·Recruiting·Listed Mar 2019

Apply to this trial

Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)

for Geriatric Assessment

Sites in Philadelphia, Lancaster +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 70+

Code: NCT06870617·Recruiting·Listed Mar 2025

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18F-Fluciclovine PET-MRI in High-grade Glioma

for Glioma

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 - 21

Code: NCT05553041·EARLY_Phase 1·Recruiting·Listed Sep 2022

Apply to this trial

Excision of Lymph Node Trial (EXCILYNT) (Mel69)

for Melanoma

Sites in Philadelphia +6 more locations

Sponsor: Craig L Slingluff, Jr

Sex: All·Age: 18+

Code: NCT05839912·Recruiting·Listed May 2023

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Prospective Breast Cancer Biospecimen Collection

for Breast Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT04074720·Recruiting·Listed Aug 2019

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Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

Sites in Philadelphia +2 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting·Listed Jan 2025

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Prostate Tissue BioBank

for Prostate Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Male·Age: 18+

Code: NCT06659614·Recruiting·Listed Oct 2024

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Conditions in Oncology (Philadelphia, PA)

Solid tumor· 57 Breast cancer· 44 Non-small cell lung cancer (NSCLC)· 36 Cancer (any)· 36 Colorectal cancer· 27 Ovarian cancer· 26 Prostate cancer· 24 Acute myeloid leukemia (AML)· 24 Pancreatic cancer· 21 Endometrial cancer· 18 Non-Hodgkin lymphoma· 18 Head and neck cancer· 16 Gastric cancer· 15 Bladder cancer· 14 Hematologic malignancy· 13 Glioma· 12 Multiple myeloma· 12 Diffuse large B-cell lymphoma (DLBCL)· 12 Esophageal cancer· 10 Myelodysplastic syndromes (MDS)· 10 Lung cancer· 9 Liver cancer· 9 Metastatic prostate cancer· 9 Kidney cancer· 9 Leukemia (other)· 9 Fallopian tube cancer· 8 Melanoma· 8 Neuroblastoma· 8 Pediatric cancer· 8 Cervical cancer· 7 Chronic lymphocytic leukemia (CLL)· 7 Neuroendocrine tumors· 7 Metastatic breast cancer· 6 Triple-negative breast cancer· 6 Biliary tract cancer· 6 Glioblastoma· 6 Hodgkin lymphoma· 6 Ewing sarcoma· 6 Osteosarcoma· 5 Gastroesophageal junction cancer· 4 Acute lymphoblastic leukemia· 4 Myelofibrosis· 4 Small lymphocytic lymphoma· 4 HER2-positive breast cancer· 3 HER2-negative breast cancer· 3 Small cell lung cancer· 3 Myeloproliferative neoplasm· 3 Follicular lymphoma· 3 Burkitt lymphoma· 3 Thyroid cancer· 3 Rhabdomyosarcoma· 3 Gastrointestinal cancer· 2 Uterine cancer· 2 Brain cancer· 2 Mantle cell lymphoma· 2 Marginal zone lymphoma· 2 Soft tissue sarcoma· 2 Metastatic colorectal cancer· 1 Chronic myelomonocytic leukemia· 1 Skin cancer· 1 Sarcoma· 1 Mesothelioma· 1