Paid Clinical Trials in Sioux Falls, SD
As of June 2026, 271 paid clinical trials are recruiting in Sioux Falls, South Dakota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Sioux Falls offers studies at sites including Sanford USD Medical Center - Sioux Falls for conditions such as Breast Cancer, Ovarian Cancer, Endometrial Cancer, Heart Failure. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Sioux Falls
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·Clear filters·↓ Download CSVAbout research studies in Sioux Falls
Sioux Falls has approximately 271 recruiting research studies across a wide range of therapeutic areas. South Dakota hosts a diverse network of universities, academic medical centers, and community hospitals that run clinical trials across oncology, cardiology, neurology, and many other therapeutic areas.
Top Research Study Locations in Sioux Falls
Researchers run research studies in Sioux Falls, SD at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Sanford USD Medical Center - Sioux Falls | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8 | 98 |
| Sanford Cancer Center Oncology Clinic | Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | 69 |
| Avera Cancer Institute | Breast Cancer, Endometrial Cancer, Ovarian Cancer | 51 |
| Sanford Health | Pregnancy, 1p36 Deletion Syndrome, 4p Deletion Syndrome, Non-Wolf-Hirschhorn Syndrome | 16 |
| Sanford Cancer Center | Carcinoma, Non-Small Cell Lung, Colo-rectal Cancer, Colon Cancer | 9 |
| Circle Clinical Research | Obesity or Overweight, Atherosclerotic Cardiovascular Disease (ASCVD), Depressive Disorder, Major | 6 |
| Avera Research Institute | Atrial Fibrillation, Developmental Delay, Idiopathic Pulmonary Fibrosis | 5 |
| Avera Research Institute - Sioux Falls | Alcohol Use Disorder, COVID-19, Migraine | 5 |
| North Central Heart | Heart Failure, Acute Limb Ischemia, Aortic Valve Disease | 5 |
| Avera Medical Group | Carcinoma, Non-Small-Cell Lung, Chronic Graft Versus Host Disease, Chronic Lymphocytic Leukemia | 3 |
| Sanford Cancer Center ( Site 0038) | Carcinoma, Non-Small-Cell Lung, Non-small Cell Lung Cancer | 3 |
| Sanford USD Medical Center | Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer, Early Breast Cancer | 3 |
| Vance Thompson Vision | Astigmatism, Blepharoplasty, Cataract | 3 |
| Avera Cancer Institute- Research ( Site 0094) | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer Metastatic, Prostatic Neoplasms | 2 |
| Avera McKennan Hospital & University Health Center | COVID-19, Migraine | 2 |
| Avera Medical Group Pediatrics - Dawley Farm | Migraine | 2 |
| Ophthalmology Ltd | Macular Edema Secondary to Inflammation | 2 |
| Ophthalmology Ltd. | Epiretinal Membrane, Neovascular Age-related Macular Degeneration | 2 |
| Orthopedic Institute | Avascular Necrosis, Osteoarthritis Shoulder, Post-traumatic Arthrosis of Other Joints, Shoulder Region | 2 |
| Sanford Research | Acute Myocardial Infarction (AMI), Cardiovascular Risk, T1D | 2 |
| Vance Thompson Vision Clinic, Prof. LLC | Dry Eye, Dry Eye Disease (DED) | 2 |
| GSK Investigational Site | Colonic Neoplasms, Neoplasms, Colon | 1 |
| Sanford Health_Sioux Falls | Heart Failure | 1 |
| Avera Cancer | Scleroderma, Diffuse | 1 |
| Avera Cancer Institue | Acute Myeloid Leukaemia (AML), Follicular Lymphoma ( FL) | 1 |
Active & Upcoming Studies in Sioux Falls (2026)
Recruiting trials in Sioux Falls grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (175 active studies)
- A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression · Phase 3 · K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
- A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer · Phase 2 · Hoffmann-La Roche
Cardiovascular (13 active studies)
Diabetes & metabolic (7 active studies)
- A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes · Phase 3 · Hoffmann-La Roche
- A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes · Phase 3 · Hoffmann-La Roche
Eye & vision (7 active studies)
- Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery · Vance Thompson Vision
- Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK · Phase 4 · Vance Thompson Vision
Neurology & pain (4 active studies)
Vaccines (3 active studies)
- EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease · Phase 3 · Pfizer
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) · Duke University
Mental health & behavior (3 active studies)
- A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse · Phase 2 · Eli Lilly and Company
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Pediatric (2 active studies)
Common conditions studied in Sioux Falls
- Breast Cancer (12 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Ovarian Cancer (9 active studies). Ovarian cancer research examines PARP inhibitors, maintenance therapies, and antibody-drug conjugates for recurrent and platinum-resistant disease.
- Endometrial Cancer (8 active studies). Recruiting Endometrial Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Heart Failure (7 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Stage IV Lung Cancer AJCC v8 (7 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
- Malignant Solid Neoplasm (5 active studies). Recruiting Malignant Solid Neoplasm studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Sioux Falls
- National Cancer Institute (NCI)
- Merck Sharp & Dohme LLC
- Children's Oncology Group
- NRG Oncology
- AstraZeneca
Local regulations and guidelines
Clinical trials in South Dakota are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. South Dakota research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Sioux Falls. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Sioux Falls
Hipa.ai aggregates every recruiting study in Sioux Falls from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Sioux Falls?
There are approximately 271 recruiting clinical trials in Sioux Falls, South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Sioux Falls pay participants?
Most recruiting trials in Sioux Falls compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Sioux Falls?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Sioux Falls?
The most common conditions under active study in Sioux Falls include Breast Cancer (12), Ovarian Cancer (9), Endometrial Cancer (8), Heart Failure (7), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Sioux Falls?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Sioux Falls on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Sioux Falls?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Sioux Falls?
Recruiting research sites in Sioux Falls include Sanford USD Medical Center - Sioux Falls, Sanford Cancer Center Oncology Clinic, Avera Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Sioux Falls right now?
The largest active categories in Sioux Falls are Cancer & tumors (175), Cardiovascular (13), Diabetes & metabolic (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.