Paid Clinical Trials in Yankton, SD
As of July 2026, 17 paid clinical trials are recruiting in Yankton, South Dakota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Yankton offers studies at sites including Avera Cancer Institute at Yankton for conditions such as Breast Cancer, Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Yankton
Trials by drug in Yankton
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17 clinical trials
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Avera Cancer Sequencing and Analytics Protocol (ASAP)
Top Research Study Locations in Yankton
Researchers run research studies in Yankton, SD at 3 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Avera Cancer Institute at Yankton | Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma | 11 |
| Avera Cancer Institute - Yankton | Breast Cancer, CNS Cancer, Cancer | 5 |
| AMG Oncology and Hematology Avera Cancer Institute - Yankton | Breast Cancer | 1 |
Active & Upcoming Studies in Yankton (2026)
Recruiting trials in Yankton grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (15 active studies)
- Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL · Phase 3 · Alliance for Clinical Trials in Oncology
- A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer · Phase 2 · Hoffmann-La Roche
Common conditions studied in Yankton
- Breast Cancer (3 active studies)
- Recurrent Head and Neck Squamous Cell Carcinoma (2 active studies)
- Recurrent Hypopharyngeal Squamous Cell Carcinoma (2 active studies)
- Recurrent Laryngeal Squamous Cell Carcinoma (2 active studies)
- Recurrent Oral Cavity Squamous Cell Carcinoma (2 active studies)
- Recurrent Oropharyngeal Squamous Cell Carcinoma (2 active studies)
Leading research sponsors in Yankton
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- Merck Sharp & Dohme LLC
- NRG Oncology
- Avera McKennan Hospital & University Health Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Yankton?
There are approximately 17 recruiting clinical trials in Yankton, South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Yankton pay participants?
Most recruiting trials in Yankton compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Yankton?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Yankton?
The most common conditions under active study in Yankton include Breast Cancer (3), Recurrent Head and Neck Squamous Cell Carcinoma (2), Recurrent Hypopharyngeal Squamous Cell Carcinoma (2), Recurrent Laryngeal Squamous Cell Carcinoma (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Yankton?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Yankton on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Yankton?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Yankton?
Recruiting research sites in Yankton include Avera Cancer Institute at Yankton, Avera Cancer Institute - Yankton, AMG Oncology and Hematology Avera Cancer Institute - Yankton, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Yankton right now?
The largest active categories in Yankton are Cancer & tumors (15). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.