As of July 2026, 242 paid clinical trials are recruiting in Sioux Falls, South Dakota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Sioux Falls offers studies at sites including Sanford USD Medical Center - Sioux Falls for conditions such as Breast Cancer, Ovarian Cancer, Endometrial Cancer, Stage IV Lung Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Sioux Falls, SD at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Sanford USD Medical Center - Sioux Falls | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8 | 88 |
| Sanford Cancer Center Oncology Clinic | Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | 63 |
| Avera Cancer Institute | Breast Cancer, Endometrial Cancer, Ovarian Cancer | 42 |
| Sanford Health | Pregnancy, 1p36 Deletion Syndrome, 4p Deletion Syndrome, Non-Wolf-Hirschhorn Syndrome | 15 |
| Sanford Cancer Center | Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer, Endometrial Cancer | 14 |
| North Central Heart | Heart Failure, Acute Limb Ischemia, Aortic Valve Disease | 6 |
| Circle Clinical Research | Obesity or Overweight, Atherosclerotic Cardiovascular Disease (ASCVD), Depressive Disorder, Major | 5 |
| Avera Cancer Institute- Research | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer Metastatic, Prostatic Neoplasms | 5 |
| Avera Research Institute | Atrial Fibrillation, Developmental Delay, Idiopathic Pulmonary Fibrosis | 4 |
| Sanford USD Medical Center | Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer, Early Breast Cancer | 4 |
| Avera Medical Group | Chronic Graft Versus Host Disease, Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma | 3 |
| Avera Research Institute - Sioux Falls | Alcohol Use Disorder, Opioid Use Disorder | 3 |
| Vance Thompson Vision | Astigmatism, Blepharoplasty, Cataract | 3 |
| Avera Cancer | Chronic Myelogenous Leukemia - Chronic Phase, Scleroderma, Diffuse | 2 |
| Ophthalmology Ltd | Macular Edema Secondary to Inflammation | 2 |
| Sanford Oncology Clinic and Pharmacy | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer | 2 |
| Vance Thompson Vision Clinic, Prof. LLC | Dry Eye, Dry Eye Disease (DED) | 2 |
| Avera Cancer Institute - Sioux Falls | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 2 |
| GSK Investigational Site | Colonic Neoplasms, Neoplasms, Colon | 1 |
| Avera Cancer Institue | Acute Myeloid Leukaemia (AML), Follicular Lymphoma ( FL) | 1 |
| Avera Cancer Institute Sioux Falls | Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cancer | 1 |
| Avera Heart Hospital of South Dakota | Heart Failure - NYHA II - IV | 1 |
| Avera McKennan Hospital & University Health Center | Migraine | 1 |
| Avera McKennan Hospital | Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms, Triple Negative Breast Neoplasms | 1 |
| Avera Medical Group Gynecologic | Ovarian Cancer | 1 |
Recruiting trials in Sioux Falls grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 242 recruiting clinical trials in Sioux Falls, South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Sioux Falls compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Sioux Falls include Breast Cancer (10), Ovarian Cancer (9), Endometrial Cancer (8), Stage IV Lung Cancer AJCC v8 (7), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Sioux Falls on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Sioux Falls include Sanford USD Medical Center - Sioux Falls, Sanford Cancer Center Oncology Clinic, Avera Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Sioux Falls are Cancer & tumors (153), Cardiovascular (12), Eye & vision (8). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.