As of July 2026, 61 paid clinical trials are recruiting in Rapid City, South Dakota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Rapid City offers studies at sites including Rapid City Regional Hospital for conditions such as Heart Failure, Obesity, Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Rapid City, SD at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Rapid City Regional Hospital | Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma | 15 |
| Monument Health | Heart Failure, Breast Reconstruction | 5 |
| Monument Health Clinical Research | Obesity, Atherosclerotic Cardiovascular Disease, Atrial Fibrillation (AF) | 5 |
| Health Concepts | Gout, Moderate to Severe Chronic Obstructive Pulmonary Disease, Tophaceous Gout | 5 |
| Monument Health Clinical Rsrch | Obesity, Diabetes Mellitus, Type 2, Heart Failure | 3 |
| Black Hills Regional Eye Institute | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA), Neovascular Age-Related Macular Degeneration (nAMD) | 3 |
| Black Hills Center for American Indian Health | Smoking Cessation, Cigarette Smoking | 2 |
| Monument Health Rapid City Hospital | Breast Carcinoma, Colorectal Carcinoma, Lumbar Spinal Stenosis | 2 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis | 1 |
| Black Hills Surgical Hospital | Lumbar Spinal Stenosis | 1 |
| Care Access - Rapid City | Osteoarthritis | 1 |
| Center for Indigenous Health - Great Plains Hub | Diabetes | 1 |
| GSK Investigational Site | Asthma | 1 |
| Local Institution - 0084 | Plaque Psoriasis | 1 |
| Monument Health Cancer Care Institute | Triple Negative Breast Cancer | 1 |
| Monument Health Clinical Research, Monument Health Rapid City Hospital Inc. | Acute Myocardial Infarction | 1 |
| Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc. | Heart Failure, Heart Failure With Reduced Ejection Fraction | 1 |
| Monument Health Heart and Vascular Institute | Aortic Stenosis, Aortic Valve Disease, Aortic Valve Stenosis | 1 |
| Ohio State University Telemedicine | Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma, Stage II Pancreatic Cancer AJCC v8 | 1 |
| Plastic Surgical Center of Rapid City | Lumbar Spinal Stenosis | 1 |
| Rapid City Medical Center, LLC | Moderately to Severely Active Crohn Disease | 1 |
| Rapid City Medical Center, LLP | Ulcerative Colitis | 1 |
| Same Day Surgery Center | Lumbar Spinal Stenosis | 1 |
| Sanford Health Research | Crohn's Disease | 1 |
| University of Michigan/Rapid City | Anxiety, Depression, Drug Use | 1 |
Recruiting trials in Rapid City grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 61 recruiting clinical trials in Rapid City, South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Rapid City compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Rapid City include Heart Failure (6), Obesity (4), Advanced Esophageal Adenocarcinoma (2), Advanced Gastric Adenocarcinoma (2), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rapid City on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Rapid City include Rapid City Regional Hospital, Monument Health, Monument Health Clinical Research, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Rapid City are Cancer & tumors (18), Cardiovascular (10), Diabetes & metabolic (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.