Paid Clinical Trials in Springfield, OH
As of July 2026, 27 paid clinical trials are recruiting in Springfield, Ohio. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Springfield Regional Cancer Center for conditions such as Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Springfield
Trials by drug in Springfield
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27 clinical trials
Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System
FebriDx® Pediatric Validation Study
The Lilac Device Trial - IMPACT: A Clinical Investigation on IMproving Peripheral Neuropathy Induced by Chemotherapy With Advanced Compression Technology - A Safety and Efficacy Study
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
Top Research Study Locations in Springfield
Researchers run research studies in Springfield, OH at 8 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Springfield Regional Cancer Center | Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8 | 19 |
| Springfield Regional Medical Center | Malignant Solid Neoplasm, Anatomic Stage IV Breast Cancer AJCC v8, Acral Lentiginous Melanoma | 12 |
| Buckeye Dermatology - Springfield Office | Cutaneous Squamous Cell Carcinoma (CSCC) | 1 |
| Heart House Research Foundation LLC | Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | 1 |
| Hometown Urgent Care | Acute Respiratory Infections (ARIs) | 1 |
| Ohio Valley Surgical Hospital | Lumbar Spinal Stenosis | 1 |
| Oregon Urology Institute | FGFR Gene Alterations, FGFR Gene Amplification, FGFR3 Gene Alteration | 1 |
| Springfield Medical Center | Atrial Fibrillation | 1 |
Active & Upcoming Studies in Springfield (2026)
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (16 active studies)
- Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma · Phase 3 · Regeneron Pharmaceuticals
- Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial · Phase 3 · National Cancer Institute (NCI)
Cardiovascular (4 active studies)
- A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System · Biosense Webster, Inc.
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention · Phase 4 · Duke University
Common conditions studied in Springfield
- Malignant Solid Neoplasm (3 active studies)
- Stage IIIB Lung Cancer AJCC v8 (3 active studies)
- Stage IV Lung Cancer AJCC v8 (3 active studies)
- Anatomic Stage IV Breast Cancer AJCC v8 (2 active studies)
- Acral Lentiginous Melanoma (1 active study)
- Acute Coronary Syndrome (1 active study)
Leading research sponsors in Springfield
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- ECOG-ACRIN Cancer Research Group
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Springfield?
There are approximately 27 recruiting clinical trials in Springfield, Ohio listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Springfield pay participants?
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Springfield?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Springfield?
The most common conditions under active study in Springfield include Malignant Solid Neoplasm (3), Stage IIIB Lung Cancer AJCC v8 (3), Stage IV Lung Cancer AJCC v8 (3), Anatomic Stage IV Breast Cancer AJCC v8 (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Springfield?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Springfield?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Springfield?
Recruiting research sites in Springfield include Springfield Regional Cancer Center, Springfield Regional Medical Center, Buckeye Dermatology - Springfield Office, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Springfield right now?
The largest active categories in Springfield are Cancer & tumors (16), Cardiovascular (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.