Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT04791371
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
30 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Cardiovascular exercise — BEHAVIORAL
    15 weeks of cardiovascular exercise 3x/week for 50 minutes/session

Study Details

The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.

Key Dates

First listed
Mar 10, 2021
Start date
Jun 17, 2022
Status verified
Mar 2026
Primary completion
Jan 15, 2027
Completion
Feb 15, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Type 2 Diabetes
    Participants aged 30-55 with type 2 diabetes
  • Experimental: Healthy overweight control
    Participants aged 30-55 with BMI 25-40 without type 2 diabetes

Primary Outcome Measure

Change in peak oxygen consumption (VO2) [ Time Frame: Through study completion, approximately 4 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of ColoradoAuroraColorado80045
Benjamin Juckett, MS
[email protected]
303-724-1338
Ethan Clark, MS
[email protected]
303-724-1354
Judy Regensteiner, PhD (PRINCIPAL_INVESTIGATOR)
Jane Reusch, MD (PRINCIPAL_INVESTIGATOR)
University of VirginiaCharlottesvilleVirginia22908
Lee Hartline, MEd
[email protected]
434-924-5247
Linda Jahn, RN
[email protected]
434-924-1134
Zhenqi Liu, MD (PRINCIPAL_INVESTIGATOR)

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University of Colorado· Aurora, COUniversity of Virginia· Charlottesville, VA

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