A Phase 1/2 Study of BA3071 in Patients With Solid Tumors

Part of paid clinical trials in Los Angeles, California.

Sponsor
BioAtla, Inc.
Study ID
NCT05180799
Phase
PHASE1/PHASE2
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BA3071 — BIOLOGICAL
    Conditionally active biologic (CAB) antibody that binds to CTLA-4
  • Nivolumab — BIOLOGICAL
    Humanized, immunoglobulin G4 (IgG4)-variant mAb against PD-1
  • Pembrolizumab — BIOLOGICAL
    Humanized antibody, immunoglobulin G4, with a variable region against the human PD-1 receptor
  • Pemetrexed (Alimta) — DRUG
    pemetrexed with either cisplatin or carboplatin

Study Details

The objective of this study is to assess safety and efficacy of BA3071 in solid tumors

Key Dates

Start date
Aug 3, 2022
Status verified
Oct 2024
Primary completion
Mar 19, 2025
Completion
Jun 30, 2026

Study Design

Enrollment
320 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: BA3071
    Conditionally active biologic (CAB) antibody that binds to CTLA-4
  • Experimental: Combination Therapy
    Conditionally active biologic (CAB) antibody that binds to CTLA-4 with PD-1 inhibitor
  • Experimental: Combination Therapy + Chemotherapy
    Conditionally active biologic (CAB) antibody that binds to CTLA-4 with PD-1 inhibitor + Chemotherapy
  • Experimental: Neoadjuvant Combination Therapy + Chemotherapy
    Conditionally active biologic (CAB) antibody that binds to CTLA-4 with PD-1 inhibitor + Chemotherapy prior to surgical resection

Primary Outcome Measure

Assess dose limiting toxicity as defined in the protocol [ Time Frame: Up to 24 months ]

Locations (9)

FacilityCityStateZIPSite coordinators
The Angeles Clinic and Research InstituteLos AngelesCalifornia90025-
USC Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
Piedmont WestAtlantaGeorgia30318-
Northwest Cancer CentersDyerIndiana46311-
Morristown Medical Center/Atlantic Health SystemMorristownNew Jersey07960-
Icahn School of Medicine at Mt. SinaiNew YorkNew York10029-
University Hospitals Cleveland Medical CenterClevelandOhio44106-
Providence Cancer InstitutePortlandOregon97213-
University of Utah Huntsman Cancer InstituteSalt Lake CityUtah84112-

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By research site
The Angeles Clinic and Research Institute· Los Angeles, CAUSC Norris Comprehensive Cancer Center· Los Angeles, CAPiedmont West· Atlanta, GANorthwest Cancer Centers· Dyer, INMorristown Medical Center/Atlantic Health System· Morristown, NJIcahn School of Medicine at Mt. Sinai· New York, NY

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