Precision Physical Exercise for Personalized Onco-Hematology.

Sponsor
University of Salamanca
Study ID
NCT07286539
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Supervised Intervention — OTHER
    A strength training programme conducted twice per week for 12 weeks under professional supervision, complemented by a home-based exercise programme.
  • Home-based Intervention — OTHER
    A home-based exercise programme following the same recommendations and guidelines as a supervised group but without supervised in-person sessions.

Study Details

Physical exercise, particularly strength training, has become an effective strategy to improve physical function, muscle mass, and quality of life in cancer patients. However, the biological mechanisms underlying these benefits remain poorly understood, especially during active treatment. The PEPOH project (Precision physical Exercise for Personalized Onco-Hematology) proposes a single-center clinical trial conducted at the Fundación del Instituto de Investigación Biomédica de Salamanca (FIBSAL) including five different patient cohorts: lung, colorectal (CRC), and breast cancer, chronic lymphocytic leukemia, and multiple myeloma. Participants will be randomly assigned to either an in-person intervention group, performing a supervised strength training program twice a week for 12 weeks combined with a home-based exercise program, or a control group performing only the home-based program. Biological samples will be collected before and after the intervention for multi-dimensional characterization (Genomics, Transcriptomics, Proteomics and Metabolomics) and systematic integration with parameters of functional capacity, quality of life, psychological well-being, frailty, and body composition. The main objective of the project is to determine biological parameters associated with strength exercise and their relationship with clinical parameters related to prognosis, therapy response and survival. This multi-dimensional approach will enable the detection of exercise adaptation biomarkers and generate knowledge about the mechanisms linking exercise with improved health outcomes in individuals with cancer. PEPOH will contribute to biomedical science and will enhance the comprehensive care of oncohematologic patients by integrating multi-omic and clinical data into a precision exercise model. This project will also contribute to society by offering a cost-effective, safe, and transferable intervention, which increases the overall quality of life.

Key Dates

First listed
Dec 16, 2025
Start date
Apr 1, 2026
Status verified
Dec 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2030

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Supervised Intervention Grou'p
    Supervised intervention group: a strength training programme conducted twice per week for 12 weeks under professional supervision, complemented by a home-based exercise programme.
  • Experimental: Control Group
    Control group: a home-based exercise programme following the same recommendations and guidelines as a supervised group but without supervised in-person sessions.

Primary Outcome Measure

Functional physical condition [ Time Frame: 36 months ]

Central Contacts

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