Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Study ID
NCT07650682
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Study Details

This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions. The purpose of this study is to develop mathematical models and digital representations ("digital twins") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.

Key Dates

Start date
May 20, 2026
Status verified
Jun 2026
Primary completion
Oct 20, 2026
Completion
Mar 20, 2027

Study Design

Enrollment
25 participants (estimated)

Arms

  • Arm: Adults With Insulin-Dependent Type 2 Diabetes Mellitus
    Adults 18 to 65 years of age with insulin-dependent type 2 diabetes mellitus who will undergo a liquid meal tolerance test with frequent blood sampling over 4 hours following consumption of a standardized liquid meal. Participants will also undergo outpatient continuous glucose monitoring and wearable physical activity tracking during free-living conditions to support mathematical modeling of metabolic and physiologic responses.

Primary Outcome Measure

Change in Plasma Glucose Concentration (mg/dL) [ Time Frame: -10 to 240 minutes relative to meal consumption ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Illinois Institute of TechnologyChicagoIllinois60616
Chelsea Preiss, MS
[email protected]
312-567-5300
Indika Edirisinghe, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chicago, IL

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Illinois Institute of Technology· Chicago, IL

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