Ecological Momentary Assessment of State-Dependent Decision-Making and Metacognition Across a Psychopathology Continuum

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Mental Health (NIMH)
Study ID
NCT07801079
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Study Details

Background: Life experiences could impact how one feel, and in turn alter how decisions are made. For example, an argument with a loved one might lead to frustration that drives one to seek alcohol or engage in other riskier decision-making. By tracking not only how life experiences might change feelings but also the decision-making tendencies assessed by behavioral tasks, researcher aimed to better understand naturalistically how life experiences might shape behaviors through feelings. This could lead to a better understanding, identification and treatment for people with mental disorders. Objective: Naturalistically track how life experiences change self-reported mental states, such as emotions or mood, as well as decision-making tendencies. Eligibility: Individuals aged 18 to 55 years, who are either healthy or with varying degrees of depressive, anxious or addictive symptom severity. Design: Participants in the study will complete the following activities: 1) complete an initial assessment of their medical, mental health and personal history; 2) complete a set of behavior tasks; 3) for 12 weeks, complete surveys, tasks and audiovisual diary on a smart phone while they go about their life; 4) for 12 weeks, continuously wear an smartwatch-like device to track physiological signals; 5) every 2 weeks for 12 weeks, complete a set of surveys on mental health conditions; and 6) complete an end-of-study debriefing session to discuss their experience in the study.

Key Dates

First listed
Sep 3, 2026
Start date
Nov 19, 2026
Status verified
Aug 2026
Primary completion
Aug 19, 2031
Completion
Aug 20, 2032

Study Design

Enrollment
420 participants (estimated)

Arms

  • Arm: Transdiagnostic Dimensional Cohort
    Individuals with varying degrees of depression, anxiety and addiction symptom severity, including those who have none of the symptoms (healthy volunteer).

Primary Outcome Measure

To establish the relationship between psychiatric symptom severity and the reactivity of decision-making to changes in internal state. [ Time Frame: Throughout the study, transdiagnostic measures of trait- and state-level symptom severity and clinical diagnosis determined by Structured Clinical Interview for DSM Disorders (SCID). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
NIH Clinical Center Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

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By research site
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