Acute lymphoblastic leukemia Clinical Trials

Recruiting acute lymphoblastic leukemia studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat acute lymphoblastic leukemia. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting acute lymphoblastic leukemia studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting acute lymphoblastic leukemia trials

Within

Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic Malignancies

for Hematologic Malignancy

Sponsor: Ossium Health, Inc.

Sex: All·Age: 12 - 75

Code: NCT07710781

HEM-iSMART E: Capivasertib + Venetoclax + Dexamethasone in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

for Acute Lymphoblastic Leukemia

Sponsor: Princess Maxima Center for Pediatric Oncology

Sex: All·Age: 2 - 21

Code: NCT07175415·Phase 1, Phase 2

Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Patients With Measurable Residual Disease Positive B-cell Acute Lymphoblastic Leukemia

for Phase 2 Study

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07192237·Phase 2

CAR-T Treatment in Pediatric and Adult Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto

Sex: All·Age: All ages

Code: NCT07623655

A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymph...

for B-All

8 sites incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 25

Code: NCT05621291

Apply to this trial

Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for B-All

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07572136·Phase 1

Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL)

for Acute Lymphoblastic Leukemia

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 1 - 30

Code: NCT07387926·Phase 1, Phase 2

Apply to this trial

SHR2554/AZA + Overlapped TBF for High-risk/Relapsed Leukemia/MDS

for Acute Myeloid Leukemia

Sponsor: The First Affiliated Hospital of Soochow University

Sex: All·Age: 15 - 60

Code: NCT07562568·Phase 2

SHR2554/AZA + Overlapped Modified BUCY for High-risk/Relapsed Leukemia/MDS

for Acute Myeloid Leukemia

Sponsor: The First Affiliated Hospital of Soochow University

Sex: All·Age: 18 - 65

Code: NCT07575412·Phase 2

CD22 CAR T-cells to Extend Remission Following Commercial CD19 CAR T-cells in Children, Adolescents, and Adults With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 3 - 65

Code: NCT07328503·Phase 2

Apply to this trial

Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (STEP-ALL)

for Leukemia

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT07634653

Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients

for Acute Lymphoblastic Leukemia

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: Up to 30

Code: NCT07313592

Apply to this trial

Phase I Study of FXS0683 in the Treatment of Blood Tumors

for B-Cell Lymphoma

Sponsor: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.

Sex: All·Age: 18+

Code: NCT07616089·Phase 1

ABL/JAK Inhibitors With Chemotherapy and Venetoclax for Ph-like ALL

for Ph-Like

Sponsor: Institute of Hematology & Blood Diseases Hospital, China

Sex: All·Age: 14 - 60

Code: NCT07454226

Apply to this trial

Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 15+

Code: NCT06446661

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A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

for Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

3 sites incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07020533·Phase 1

Apply to this trial

ALL Backbone in AYAs

for Acute Lymphoblastic Leukemia

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 51

Code: NCT07227584·Phase 2

Cord Blood Transplantation in Children and Young Adults With Blood Cancer

for Acute Myelogenous Leukemia

1 site in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: Up to 26

Code: NCT07566377·Phase 2

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Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity

for Acute Lymphoblastic Leukemia

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 18+

Code: NCT07228741·Phase 2

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HEM-SURVIVE: Structuralized Follow-up for Childhood Hematological Malignancy Survivors

for Acute Lymphoblastic Leukemia

Sponsor: The Children's Hospital of Zhejiang University School of Medicine

Sex: All·Age: 1 - 21

Code: NCT07483749

Treatment for Ph-negative ALL for Adults up to 65 Years

for Acute Lymphoblastic Leukemia

Sponsor: PETHEMA Foundation

Sex: All·Age: 18 - 65

Code: NCT07443592

MB-CART19.1 in Relapsed/Refractory Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: King Hussein Cancer Center

Sex: All·Age: 1+

Code: NCT07371403

Apply to this trial

Physical Activity and Exercise During Early Treatment Phases for Childhood Acute Lymphoblastic Leukaemia to Protect Against Muscle Loss and Improve Frailty Outcomes

for Sarcopenia

Sponsor: Murdoch Childrens Research Institute

Sex: All·Age: 5 - 17

Code: NCT07325305

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A Study of Obecabtagene Autoleucel in People With B-cell Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

8 sites incl. Stanford

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 40+

Code: NCT07400029·Phase 2

Apply to this trial

The Association Between Gut Microbiome Composition Signature and Cancer-related Symptoms in Children With Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: Sun Yat-sen University

Sex: All·Age: 5 - 18

Code: NCT07515430

A Study of Revumenib and Mezigdomide in People With Leukemia

for Leukemia

10 sites incl. Duarte

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 12+

Code: NCT07356154·Phase 1, Phase 2

Apply to this trial

Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During Induction Phase

for Neutropenic Fever

Sponsor: Gadjah Mada University

Sex: All·Age: 6 Months - 18

Code: NCT07320534·Phase 4

Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06735690·EARLY_Phase 1

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Telematic Cognitive Training and Mindfulness in Pediatric Patients After CAR-T Cell Therapy, Single Hematopoietic Allogeneic Transplant or Chemotherapy

for Acute Lymphoblastic Leukemia

Sponsor: Hospital Universitario La Paz

Sex: All·Age: 8 - 18

Code: NCT07479927

Apply to this trial

BEBT-908 Plus Chemotherapy Treatment for CR MRD-Positive MEF2D-Rearranged and Pre-B Acute Lymphoblastic Leukemia Patients

for Acute Lymphoblastic Leukemia

Sponsor: Ruijin Hospital

Sex: All·Age: 18 - 75

Code: NCT07301138·Phase 2

Clinical Study of LV009 Injection for the Treatment of Hematologic and Lymphoid Malignancies

for Non-Hodgkin Lymphoma

Sponsor: PersonGen BioTherapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18 - 70

Code: NCT07284927·Phase 1

Apply to this trial

A Study of 14C-Bleximenib (Radiolabeled) in Participants With Acute Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07295951·Phase 1

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HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

for Acute Lymphoblastic Leukemia

Sponsor: Princess Maxima Center for Pediatric Oncology

Sex: All·Age: 1 - 21

Code: NCT05751044·Phase 1, Phase 2

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Efficacy of Targeted Drugs Combined With Chemotherapy in the Treatment of T-ALL

for Acute Lymphoblastic Leukemia

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 70

Code: NCT07203352·Phase 3

Apply to this trial

The Effect of Mandala on Anxiety and Fear Levels in Children With Leukemia Before Intrathecal Chemotherapy Treatment

for Acute Lymphoblastic Leukemia

Sponsor: Ege University

Sex: All·Age: 4 - 12

Code: NCT07203742

Apply to this trial

Mobile Health Intervention to Support Oral Chemotherapy Adherence in Adolescents and Young Adults With Leukemia

for Acute Lymphoblastic Leukemia

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 14+

Code: NCT03932903

Apply to this trial

CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study

for Acute Lymphoblastic Leukemia

Sponsor: Zhujiang Hospital

Sex: All·Age: 14 - 80

Code: NCT07072494·Phase 1, Phase 2

Apply to this trial

A Phase 1 Study of FIT-CD19-CAR-T Cells in R/R B-ALL

for Acute Lymphoblastic Leukemia

Sponsor: TriArm Therapeutics (Taiwan) Limited

Sex: All·Age: 18+

Code: NCT07066397·Phase 1

Apply to this trial

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06287944·Phase 1

Apply to this trial

CAYA Cancer Retrospective Cohort Study

for Acute Lymphoblastic Leukemia

Sponsor: Resonance, Inc.

Sex: All·Age: 0 - 21

Code: NCT07246213

Apply to this trial

Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies

for Neutropenic Fever

Sponsor: Gadjah Mada University

Sex: All·Age: Up to 18

Code: NCT07016165·Phase 4

Apply to this trial

CAR T CELL Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive Leukemia

for Acute Lymphoblastic Leukemia

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT06847269·Phase 2

Apply to this trial

Full-Course Immunotherapy Consolidation for Unfit or Fit B-ALL Who Decline Chemotherapy

for Acute Lymphoblastic Leukemia

Sponsor: The First Affiliated Hospital of Soochow University

Sex: All·Age: 15+

Code: NCT06985485·Phase 2

Apply to this trial

A 3-cohort Randomized Study Evaluating the Role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults With Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 65

Code: NCT06860269·Phase 2, Phase 3

Apply to this trial

CD19-CD22-Bispecific Chimeric Antigen Receptor (CAR) T Cell Therapy for Pediatric Patients With Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT06777979·Phase 1

Apply to this trial

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

for Acute Lymphoblastic Leukemia

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 80

Code: NCT06815003·Phase 2

Apply to this trial

A Phase I Clinical Trial of RS001 in Patients with Relapsed/Refractory B-Cell Malignancies

for B-cell Non-Hodgkin's Lymphoma

Sponsor: Guangdong Ruishun Biotech Co., Ltd

Sex: All·Age: 18 - 75

Code: NCT06894693·Phase 1

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

for Chronic Lung Disease

1 site in Minneapolis

Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All·Age: 8 - 25

Code: NCT05025774

Apply to this trial

Newly-diagnosed Pediatric T-cell ALL Protocol

for Acute Lymphoblastic Leukemia

Sponsor: Institute of Hematology & Blood Diseases Hospital, China

Sex: All·Age: 1 Month - 18

Code: NCT06855810·Phase 2, Phase 3

Apply to this trial

MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence

for Acute Lymphoblastic Leukemia

1 site in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06323044

Apply to this trial

Study on the Efficacy and Safety of the TmBU Conditioning Regimen in High-risk or Relapsed/Refractory Acute Leukemia

for Acute Myeloid Leukemia

Sponsor: The First Affiliated Hospital of Soochow University

Sex: All·Age: 15 - 65

Code: NCT06816134·Phase 2

Apply to this trial

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

for Acute Lymphoblastic Leukemia

3 sites incl. Charlotte

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 18

Code: NCT06533748·Phase 2

Apply to this trial

Inaticabtagene Autoleucel (Inati-cel; CNCT19) Treatment for Newly Diagnosed B-cell ALL Patients in CR1

for Acute Lymphoblastic Leukemia

Sponsor: First Affiliated Hospital of Zhejiang University

Sex: All·Age: 14 - 70

Code: NCT06777264·Phase 2

Effects of Core Stabilization Exercises in Children with Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: Karamanoğlu Mehmetbey University

Sex: All·Age: 6 - 18

Code: NCT06794762

Apply to this trial

Efficacy of Short-course Blinatumomab for MRD Erradication in B-ALL

for Acute Lymphoblastic Leukemia

Sponsor: Hospital Universitario Dr. Jose E. Gonzalez

Sex: All·Age: 16 - 60

Code: NCT06886074·Phase 2

Apply to this trial

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

for Acute Lymphoblastic Leukemia

5 sites incl. San Diego

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 18

Code: NCT06289673·Phase 4

Apply to this trial

Inaticabtagene Autoleucel (Inati-cel; CNCT19) Treatment for MRD-Positive B-ALL Patients in CR1

for Acute Lymphoblastic Leukemia

Sponsor: Ruijin Hospital

Sex: All·Age: 16 - 70

Code: NCT06718244·Phase 2

Apply to this trial

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

for Acute Leukemia

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 2+

Code: NCT06575296·Phase 1

Apply to this trial

Systemic Inflammation Response Index and C-Reactive Protein to Albumin Ratio in Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Sponsor: Assiut University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06674850

Early Assessment of Cardiac Function After Treatment With CAR-T Cells

for Car T- Cell

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT06350994

Apply to this trial

Acute lymphoblastic leukemia clinical trials — common questions

Are acute lymphoblastic leukemia clinical trials free to join?

Yes. Participating in a acute lymphoblastic leukemia clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a acute lymphoblastic leukemia clinical trial?

Each acute lymphoblastic leukemia study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a acute lymphoblastic leukemia trial near me?

Use the location controls above. We'll show recruiting acute lymphoblastic leukemia trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many acute lymphoblastic leukemia trials are recruiting right now?

We're currently tracking roughly 68 recruiting acute lymphoblastic leukemia trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Acute lymphoblastic leukemia trials by city

Duarte, CA Los Angeles, CA Chicago, IL Seattle, WA Tampa, FL Aurora, CO Birmingham, AL Gainesville, FL Madison, WI Orange, CA Palo Alto, CA Salt Lake City, UT

Related specialties

Oncology Blood cancer Pediatric oncology