Barrett's esophagus Clinical Trials

Recruiting barrett's esophagus studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat barrett's esophagus. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting barrett's esophagus studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting barrett's esophagus trials

Within

Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy

for Reflux Disease, Gastro-Esophageal

Sponsor: Hospital de Mataró

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07607067

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07206589

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

6 sites incl. Kansas City

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2

Apply to this trial

A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer

for Barrett Esophagus

Sponsor: University Hospital, Antwerp

Sex: All·Age: 18+

Code: NCT07455422

Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Esophageal Adenocarcinoma

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07212491

Impact of RFA on Esophageal Distensibility and Mucosal Impedance

for Dysplastic Barrett's Esophagus

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07126535

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Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

for Obese Patients

1 site in Cleveland

Sponsor: Louis Stokes VA Medical Center

Sex: All·Age: 40 - 85

Code: NCT06746623

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Barrett's Esophagus in Patients with GERD

for Barrett Esophagus

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT06897540

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for Barrett Esophagus

5 sites incl. Aurora

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06687603

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"Less-is-more in Barrett-surveillance" Care Evaluation of Barrett's Patients With Low-Risk in Whom Endoscopic Surveillance is Stopped. The BLISS Project.

for Barrett Esophagus

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: All ages

Code: NCT06803147

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Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Device Samples

for Barrett Esophagus

1 site in Cordova

Sponsor: Cyted Health Inc

Sex: All·Age: 18+

Code: NCT06803927

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Ultralong-segment Barrett's Esophagus: Towards a Capsule-sponge Surveillance Strategy

for Barrett Esophagus

Sponsor: Erasmus Medical Center

Sex: All·Age: 18+

Code: NCT06720636

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Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

for Barrett Esophagus

3 sites in Denver

Sponsor: Denver Health and Hospital Authority

Sex: All·Age: 18 - 65

Code: NCT06532734

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Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests

for Gastro Esophageal Reflux Disease

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06693622

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Molecular Assessment for Gastro-Esophageal Cancer

for Esophageal Cancer

Sponsor: KU Leuven

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06346054

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Obeticholic Acid for Prevention in Barrett's Esophagus

for Barrett Esophagus

8 sites incl. Kansas City

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04939051·Phase 2

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Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT06071845

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Study to Evaluate EnteroTracker® as a Sampling Method to Screen for Barrett's Esophagus/Esophageal Cancer

for Barrett Esophagus

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT05706025

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

for Cancer Risk

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05463796

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Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)

for Airway Disease

1 site in New York

Sponsor: NYU Langone Health

Sex: Male·Age: 37 - 90

Code: NCT05216133

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

23 sites incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748

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A Multicenter Prospective Cohort Study Comparing Random Biopsies Versus Wide-Area Transepithelial Brush-Sampling (WATS) for Surveillance of Barrett's Esophagus, the WATS-EURO2 Study

for Barrett Esophagus

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: 18+

Code: NCT05642338

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Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

for Barrett Esophagus

14 sites incl. Gilbert

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05530343

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A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus

for Barrett Esophagus

Sponsor: University Hospital, Angers

Sex: All·Age: 18+

Code: NCT04867590

Apply to this trial

Endoscopic Submucosal Dissection (ESD)

for Esophageal Lesion

1 site in Orlando

Sponsor: AdventHealth

Sex: All·Age: 18+

Code: NCT05468008

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Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett Esophagus

3 sites incl. Austin

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT03961945

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Longitudinal Oral Microbiome Sampling for BE

for Barrett Esophagus

2 sites incl. Ann Arbor

Sponsor: Columbia University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05133102

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Clinical Utility of WATS3D: A 5-Year Prospective Study

for Barrett Esophagus

1 site in Bethpage

Sponsor: CDx Diagnostics

Sex: All·Age: 18+

Code: NCT04312633

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The Johns Hopkins Heartburn Center Registry

for Gastroesophageal Reflux Disease

9 sites incl. Orange

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT03853772

Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting

for Barrett Esophagus

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04561791

Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barrett's Esophagus

for Barrett Esophagus

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 75

Code: NCT04457193

Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

for Barrett Esophagus

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03830801

Apply to this trial

Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma

for Submucosal Esophageal Adenocarcinoma

Sponsor: Amsterdam UMC

Sex: All·Age: 18+

Code: NCT03222635

Apply to this trial

EsophaCap for the Detection of Early Esophageal Carcinoma

for Barrett Esophagus

2 sites in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04214119

Apply to this trial

Barrett's esophagus clinical trials — common questions

Are barrett's esophagus clinical trials free to join?

Yes. Participating in a barrett's esophagus clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a barrett's esophagus clinical trial?

Each barrett's esophagus study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a barrett's esophagus trial near me?

Use the location controls above. We'll show recruiting barrett's esophagus trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many barrett's esophagus trials are recruiting right now?

We're currently tracking roughly 26 recruiting barrett's esophagus trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Barrett's esophagus trials by city

Aurora, CO Boston, MA Ann Arbor, MI Cleveland, OH Denver, CO Los Angeles, CA Orange, CA Orlando, FL

Related specialties

Gastroenterology