Down syndrome Clinical Trials

Recruiting down syndrome studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat down syndrome. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting down syndrome studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting down syndrome trials

Within

Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome

for Down Syndrome

Sponsor: University of Southern California

Sex: All·Age: 10 Months - 13 Months

Code: NCT07631130

Escalating Doses of Memantine in Down Syndrome (MEDS-123)

for Down Syndrome

1 site in Cleveland

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 15 - 32

Code: NCT07531940·Phase 1

Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy

for Down Syndrome

1 site in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 1 - 120·Accepts healthy volunteers

Code: NCT07416201

Apply to this trial

Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1

for Down Syndrome

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 6 - 22

Code: NCT07598643·Phase 2

Apply to this trial

Collaboration for Down Syndrome Progress (CDP)

for Down Syndrome

16 sites incl. Orange

Sponsor: RTI International

Sex: All·Age: All ages

Code: NCT07625579

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HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome

for Down Syndrome

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07296861

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Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome

for Down Syndrome

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07238465·Phase 3

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Endotype DIrected Treatment for OSA in Down Syndrome

for Obstructive Sleep Apnea (OSA)

5 sites incl. Tucson

Sponsor: University of Arizona

Sex: All·Age: 6+

Code: NCT07280468·Phase 4

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Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 8 - 14

Code: NCT07484464

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Rebound Therapy on Ventilatory Functions in Down Syndrome

for Down Syndrome

Sponsor: Beni-Suef University

Sex: All·Age: 9 - 13

Code: NCT07425353

Drumming Lessons' Influence on Children With Down Syndrome

for Down Syndrome

1 site in Nashville

Sponsor: Vanderbilt University

Sex: All·Age: 7 - 15

Code: NCT07156318

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Resilience Training Intervention: Its Effect on Parental Acceptance/Rejection and Burden of Children With Down Syndrome

for Down Syndrome

Sponsor: Ain Shams University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07306923

LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

for Down Syndrome

Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Sex: All·Age: 40+

Code: NCT07234695·Phase 3

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Effects of Jump Rope on Navicular Drop in Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 4 - 15

Code: NCT07428863

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Effects of Bean Bag Tossing Game on Balance and Gait in Children With Down Syndrome.

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 5 - 17

Code: NCT07578922

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Effects of Powerball in Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 6 - 10

Code: NCT07244133

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Effects of Vojta Therapy on Functional Mobility and Gait Parameters in Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 2 - 10·Accepts healthy volunteers

Code: NCT07248267

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Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 3 - 8·Accepts healthy volunteers

Code: NCT07248449

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tDCS for Catatonic Depression in Down Syndrome: A Pilot Study

for Down Syndrome

Sponsor: Hôpital le Vinatier

Sex: All·Age: 18+

Code: NCT06866925

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Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis

for Down Syndrome

Sponsor: Badr University

Sex: All·Age: 1 - 6

Code: NCT07366593

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Nutritional Status in Children With Down Syndrome

for Down Syndrome

Sponsor: Assiut University

Sex: All·Age: 2 - 5

Code: NCT06989060

Psychometric Properties of the Turkish Version of the Modified Mini Mental State Examination

for Children

Sponsor: Eastern Mediterranean University

Sex: All·Age: 5 - 18·Accepts healthy volunteers

Code: NCT06865248

The Effects Of "Minds In Motion The Maze" on Balance and Gate In Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 8 - 12

Code: NCT06955052

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Effects of Task-oriented Training on Visual-motor Integration and Upper Limb Function in Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 6 - 12

Code: NCT06943261

Effects of Interactive Sensory Play on Manual Dexterity in Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 8 - 13

Code: NCT06943352

Nordic Walk on Balance and Functional Strength in Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 8 - 13

Code: NCT06943508

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Effects of Down Dog Yoga on Pre-writing Skills in Children With Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 4 - 8

Code: NCT06977672

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Measuring Aided Language Development

for Down Syndrome

1 site in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 42 Months - 60 Months

Code: NCT06512168

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Sleep Intervention and Quality of Life in Down Syndrome

for Down Syndrome

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 12 Months - 30

Code: NCT06783725

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Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 8 - 16

Code: NCT06943170

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Shared Book Reading to Promote Mental Well-being Among Young People with and Without Down's Syndrome

for Down Syndrome

Sponsor: University of Macau

Sex: All·Age: 2 - 35·Accepts healthy volunteers

Code: NCT06813625

Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.

for Down Syndrome

Sponsor: Floriana Costanzo

Sex: All·Age: 12 - 21

Code: NCT07044804

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Physical Activity and Community EmPOWERment Project

for Intellectual Disability

2 sites incl. Fayetteville

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06740162

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How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome

for Down Syndrome

1 site in East Lansing

Sponsor: Michigan State University

Sex: All·Age: 2 - 7

Code: NCT06951516

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Effects of Pelvic Girdle Stabililty With Use of Therapeutic Taping in Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 4 - 10

Code: NCT06770218

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Effects of High Intensity Interval Training in Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 3 - 14

Code: NCT06777394

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Brain Outcomes With Lifestyle Change in Down Syndrome

for Down Syndrome

1 site in Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 64

Code: NCT05985486

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Swiss Ball Versus Frenkel Exercises Effects in Down Syndrome

for Down Syndrome

Sponsor: Riphah International University

Sex: All·Age: 8 - 13·Accepts healthy volunteers

Code: NCT06732713

Apply to this trial

Harness-based Mobility Intervention for Infants With Down Syndrome

for Down Syndrome

1 site in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: Up to 2

Code: NCT06219863

Apply to this trial

Patterns of Neurodevelopmental Disorders

for Neurodevelopmental Disorders

1 site in Phoenix

Sponsor: Richard Frye

Sex: All·Age: All ages

Code: NCT06213090

Apply to this trial

Down Syndrome, Physical Activity and Sleep Apnea

for Down Syndrome

Sponsor: University Hospital, Grenoble

Sex: All·Age: 6+

Code: NCT06061562

Apply to this trial

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

69 sites incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645

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Down Syndrome Obstructive Sleep Apnea

for Down Syndrome

7 sites incl. Los Angeles

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 5 - 18

Code: NCT06043440·Phase 2

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Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

for Obstructive Sleep Apnea

6 sites incl. Aurora

Sponsor: Oregon Health and Science University

Sex: All·Age: 2 - 17

Code: NCT05508971

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Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

for Intellectual Disability

3 sites incl. Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 6 - 24

Code: NCT05301361·Phase 1

Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome

for Down Syndrome

Sponsor: Stefano Vicari

Sex: All·Age: 10 - 17

Code: NCT06465823·Phase 2

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Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome

for Down Syndrome

Sponsor: Institut Jerome Lejeune

Sex: Male·Age: 4 - 11·Accepts healthy volunteers

Code: NCT05767216

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Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome

for Obstructive Sleep Apnea

Sponsor: Children's Health Ireland

Sex: All·Age: 6 Months - 16

Code: NCT06030349

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Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

for Obstructive Sleep Apnea

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 3 - 21

Code: NCT05527652

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Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin

for Down Syndrome

Sponsor: Institut Jerome Lejeune

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05767203

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Gamma Frequency Stimulation in Individuals With Down Syndrome

for Down Syndrome

1 site in Cambridge

Sponsor: Massachusetts Institute of Technology

Sex: All·Age: 25 - 65·Accepts healthy volunteers

Code: NCT05196984

Apply to this trial

Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

for Down Syndrome

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT05231798·Phase 2

Apply to this trial

Trial-Ready Cohort-Down Syndrome (TRC-DS)

for Down Syndrome

18 sites incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 25 - 55

Code: NCT04165109

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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

150 sites incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2

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Evaluating Treatment of ADHD in Children with Down Syndrome

for Down Syndrome

3 sites incl. Boston

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 6 - 17·Accepts healthy volunteers

Code: NCT04219280·Phase 4

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GnRH Therapy on Cognition in Down Syndrome

for Down Syndrome

Sponsor: Nelly Pitteloud

Sex: All·Age: 16 - 50

Code: NCT04390646·Phase 2, Phase 3

Apply to this trial

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

for Coronavirus Infection (COVID-19)

24 sites incl. Little Rock

Sponsor: Duke University

Sex: All·Age: 0 - 20·Accepts healthy volunteers

Code: NCT04278404

Apply to this trial

Parent and Infant Inter(X)Action Intervention (PIXI)

for Fragile X Syndrome

1 site in Research Triangle Park

Sponsor: RTI International

Sex: All·Age: Up to 99·Accepts healthy volunteers

Code: NCT03836300

Retinal Imaging in Neurodegenerative Disease

for Alzheimer's Disease

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03233646

Apply to this trial

The Human Trisome Project

for Down Syndrome

1 site in Denver

Sponsor: University of Colorado, Denver

Sex: All·Age: 6 Months - 89·Accepts healthy volunteers

Code: NCT02864108

Apply to this trial

Down syndrome clinical trials — common questions

Are down syndrome clinical trials free to join?

Yes. Participating in a down syndrome clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a down syndrome clinical trial?

Each down syndrome study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a down syndrome trial near me?

Use the location controls above. We'll show recruiting down syndrome trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many down syndrome trials are recruiting right now?

We're currently tracking roughly 29 recruiting down syndrome trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Down syndrome trials by city

Aurora, CO Birmingham, AL Boston, MA Ann Arbor, MI Cincinnati, OH Cleveland, OH Denver, CO Fayetteville, AR Little Rock, AR Los Angeles, CA Orange, CA Orlando, FL

Related specialties

Pediatrics