Pain (general) Clinical Trials

Recruiting pain (general) studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat pain (general). Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting pain (general) studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting pain (general) trials

Within

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

Optimizing Patient's Comfort During Scleral Indentation

for Pain

Sponsor: University of Alberta

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06683209

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement

for Pain

Sponsor: Henry Ford Health System

Sex: All·Age: 18+

Code: NCT07741201

Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain

for Pain

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07783672

Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement

for Vasoconstriction

Sponsor: diana garcia

Sex: All·Age: 18+

Code: NCT07696156

The Role of Virtual Reality During Regional Anesthesia

for Anxiety

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT04163809

CBD Supplementation in Brazilian Jiu-Jitsu Athletes

for Pro and Anti Inflamatory Cytokines

Sponsor: Associação Pan-Americana Multidisciplinar de Endocanabinologia

Sex: Male·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07552974·Phase 2, Phase 3

Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care

for Trismus

Sponsor: Allama Iqbal Medical College

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07719270

Context Interventions: Social Modeling and Initial Treatment Experience

for Placebo Effect

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04646460

Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children

for Anxiety

Sponsor: Ege University

Sex: All·Age: 6 - 12

Code: NCT06955338

The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery

for Pain

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07224711·Phase 4

CODEPAD-III (Collaborative Outcomes of DEpression and Pain Associated With Delivery-III)

for Depression

Sponsor: KK Women's and Children's Hospital

Sex: All·Age: 21+

Code: NCT07773259

eMindExCare for Prostate Cancer Patients Undergoing Active Treatment

for Prostate Cancer

Sponsor: The University of Hong Kong

Sex: Male·Age: 18+

Code: NCT07735273

Active vs. Passive VR During Office-based ENT Procedures

for Pain

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT07599826

Lavender Sandalwood Aromatherapy Study

for Pain

1 site in Houston

Sponsor: Memorial Hermann Health System

Sex: Female·Age: 18+

Code: NCT07737392

Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement - Open Trial

for Pain

Sponsor: Henry Ford Health System

Sex: All·Age: 18+

Code: NCT07755527

Pain and Smoking Study 2

for Smoking

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06442514

Screening Protocol

for Pain

1 site in Bethesda

Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Sex: All·Age: 12 - 100·Accepts healthy volunteers

Code: NCT07712874

Effectiveness of a Mindfulness-Based Intervention for Pain Management in Patients With Multiple Sclerosis (MPIMS).

for Multiple Sclerosis

Sponsor: Hospital Universitario Virgen Macarena

Sex: All·Age: 18 - 80

Code: NCT07741864

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

for Pain

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04650841·EARLY_Phase 1

Morphine or Ketamine for Analgesia

for Abdominal Pain

8 sites incl. Los Angeles

Sponsor: Columbia University

Sex: All·Age: 6 - 17

Code: NCT06835504·Phase 3

Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children

for Functional Abdominal Pain Disorders

2 sites incl. Austin

Sponsor: Baylor College of Medicine

Sex: All·Age: 7 - 12

Code: NCT07222943

Apply to this trial

Evaluation of Choose to Move Replacement Ready (CTM-RR)

for Osteoarthritis (OA)

Sponsor: University of British Columbia

Sex: All·Age: 50+

Code: NCT07696650

Apply to this trial

Integrated Smartphone Technology to Alleviate Malignant Pain (I-STAMP) Testing

for Advanced Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 21+

Code: NCT06117709

Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery

for Pain

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 30 - 75

Code: NCT07730294·Phase 2

Retrospective Observational Study of Oral Complications and Quality of Life in Head and Neck Cancer Patients Treated With Radiotherapy or Chemoradiotherapy.

for Oral Mucositis

Sponsor: Mucosa Innovations, S.L.

Sex: All·Age: 18+

Code: NCT07739771

Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain

for Bipolar Radiofrequency Ablation

Sponsor: Tanta University

Sex: All·Age: 50+

Code: NCT07789340

Apply to this trial

Vaginal Examination Drape Supporting Women's Privacy

for Gynecologic Examination

Sponsor: KTO Karatay University

Sex: Female·Age: 18+

Code: NCT07797309

Turkish Version of the Pictorial Pain Interference Questionnaire

for Pain

Sponsor: Istinye University

Sex: All·Age: 18+

Code: NCT07761208

Effect of Maternal Voice on Pain, Sedation, and Physiological Parameters in Mechanically Ventilated Children

for Pain

Sponsor: TC Erciyes University

Sex: All·Age: 1 - 3

Code: NCT07753486

Use of Hand Extension Rubber During Intravenous Catheter Placement

for Pain

Sponsor: Necmettin Erbakan University

Sex: All·Age: 18 - 65

Code: NCT07659015

Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy

for Dental Anxiety

Sponsor: Recep Tayyip Erdogan University Training and Research Hospital

Sex: All·Age: 6 - 8·Accepts healthy volunteers

Code: NCT07714915

Effects of Oculomotor Exercises in Patients With Non Traumatic Cervical Dizziness

for Cervical

Sponsor: Riphah International University

Sex: All·Age: 20 - 40

Code: NCT07790874

Apply to this trial

Using a Stress Ball on Fear, Anxiety, Pain, and Satisfaction During Allergy Testing

for Child Allergy

Sponsor: Tarsus University

Sex: All·Age: 4 - 10

Code: NCT07750236

Apply to this trial

Two-Point Versus Single-Point Serratus Anterior Plane Block for Post-Thoracoscopic Surgery Analgesia

for Lung Cancer

Sponsor: Shiyou Wei

Sex: All·Age: 18 - 85

Code: NCT07700823

Two Different Therapeutic Interventions Applied During Blood Sampling in Children

for Blood Sampling

Sponsor: Igdir University

Sex: All·Age: 5 - 7·Accepts healthy volunteers

Code: NCT07731347

Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment

for Cancer

1 site in Tulsa

Sponsor: University of Oklahoma

Sex: All·Age: 18+

Code: NCT07742449

Mindfulness Intervention on Minimally Invasive Vascular Surgery

for Anxiety

Sponsor: Tongji Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07463638

Role of Alprazolam in Management of Post Endodontic Pain After Single Visit Root Canal Treatment. To Compare Mean Pain Score Between Two Group of Participants Undergoing Post Operative Pain Management After Single Visit Root Canal Treatment: NSAIDs Alone and a Combination of NSAIDs and Alprazolam.

for Pain

Sponsor: Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi

Sex: All·Age: 18 - 60

Code: NCT07275710

Apply to this trial

Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome

for Carpal Tunnel Syndrome (CTS)

Sponsor: Tanta University

Sex: All·Age: 18 - 65

Code: NCT07498998

MucoLock™ for Treatment of Stomatitis

for Stomatitis

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT07506018

Apply to this trial

Effect of 4-7-8 Breathing Technique on Pain and Anxiety During Electromyography in Diabetic Neuropathy

for Diabetic Neuropathies

Sponsor: Nurgül Gün

Sex: All·Age: 18 - 70

Code: NCT07702175

Foot Reflexology and Ta-VNS for Symptom Management in Head and Neck Cancer During CCRT

for Head and Neck Neoplasms

Sponsor: Tzu Chi University

Sex: All·Age: 30 - 75

Code: NCT07711626

Apply to this trial

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

for Sickle Cell Disease

1 site in Cincinnati

Sponsor: University of Cincinnati

Sex: All·Age: 14 - 80·Accepts healthy volunteers

Code: NCT06725550

Apply to this trial

Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate vs Resin-Based Sealers

for Pain

Sponsor: Armed Forces Institute of Dentistry, Pakistan

Sex: All·Age: 18 - 60

Code: NCT07388368

Apply to this trial

Cervical Stabilization Exercises IN Subacromial Impingement Syndrome

for Subacromial Impingement Syndrome

Sponsor: Cairo University

Sex: All·Age: 20 - 40

Code: NCT07645781

Registry of Outcomes of Dezawa MuseCells®

for Osteoarthritis (OA)

1 site in North Palm Beach

Sponsor: MuseCell Innovations Pte LTD

Sex: All·Age: Up to 89

Code: NCT07645989

Apply to this trial

Effects of Music Therapy in Chronic Neck Pain

for Neck Pain

Sponsor: Karabuk University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07658729

Effect of Virtual Reality-Guided Imagery on Pain, Anxiety, and Fatigue in Cancer Patients Undergoing Chemotherapy

for Virtual Reality

Sponsor: Thoalfokar Mohammed Al-Obaidi

Sex: Female·Age: 18+

Code: NCT07677436

A Phase IV Randomized Trial of Maxigesic® Versus Standard Analgesia After Radical Gastrectomy

for Stomach Neoplasms

Sponsor: Yonsei University

Sex: All·Age: 20 - 80

Code: NCT07687394·Phase 4

Advancing Patient Care for Lymphatic Pain and Lymphedema

for Breast Cancer

1 site in Kansas City

Sponsor: University of Missouri, Kansas City

Sex: All·Age: 18 - 89

Code: NCT07701018

Midpoint Transverse Process to Pleura (MTP) Block vs Erector Spinae Plane (ESP) Block for Acute Herpes Zoster (HZ) Pain

for Midpoint Transverse Process to Pleura Block

Sponsor: Tanta University

Sex: All·Age: 21 - 60

Code: NCT07732556

Apply to this trial

Mind-Body Pilates vs Pressure Biofeedback for Chronic Non-Specific Low Back Pain

for Chronic Non Specific Low Back Pain

Sponsor: Lahore University of Biological and Applied Sciences

Sex: All·Age: 40 - 55

Code: NCT07738965

Impact of Topical Aromatherapy on Postoperative Quality of Recovery After Lung Resection

for Thoracic Surgical Procedures

Sponsor: University Hospital, Toulouse

Sex: All·Age: 18+

Code: NCT07622602

A Study of the Impact of a Virtual Reality Medical Device (HypnoVR® Headset) on Anxiety and Pain in Interventional Radiology.

for Anxiety

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07668050

Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions

for Pain

1 site in Rochester

Sponsor: University of Rochester

Sex: Female·Age: 18+

Code: NCT07542730·Phase 4

Apply to this trial

Pain During Infiltration Injection in Anterior Maxillary Region by Transcodent Painless Needle Tips Versus Regular Needle Tips

for Pain

Sponsor: Saidu College of Dentistry

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07703410

A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years

for Pain

1 site in Salt Lake City

Sponsor: HALEON

Sex: All·Age: 6 - 11·Accepts healthy volunteers

Code: NCT07632274·Phase 1

Apply to this trial

Effect of Music on Pain and Anxiety During Nail Biopsies

for Procedural Anxiety

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT07518953

Apply to this trial

New trials in Los Angeles, CA?

Pick a condition and we'll email you once a week when a new study starts recruiting in Los Angeles, CA. Unsubscribe anytime.

Pain (general) clinical trials — common questions

Are pain (general) clinical trials free to join?

Yes. Participating in a pain (general) clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a pain (general) clinical trial?

Each pain (general) study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a pain (general) trial near me?

Use the location controls above. We'll show recruiting pain (general) trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many pain (general) trials are recruiting right now?

We're currently tracking roughly 133 recruiting pain (general) trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Pain (general) trials by city

Los Angeles, CA Boston, MA Gainesville, FL Indianapolis, IN Salt Lake City, UT Tulsa, OK Aurora, CO Cincinnati, OH Miami, FL San Francisco, CA Seattle, WA Tallahassee, FL

Related specialties

Pain management