Pain (general) Clinical Trials

Recruiting pain (general) studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat pain (general). Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting pain (general) studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting pain (general) trials

Within

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement

for Vasoconstriction

Sponsor: diana garcia

Sex: All·Age: 18+

Code: NCT07696156

Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care

for Trismus

Sponsor: Allama Iqbal Medical College

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07719270

Context Interventions: Social Modeling and Initial Treatment Experience

for Placebo Effect

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04646460

Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children

for Anxiety

Sponsor: Ege University

Sex: All·Age: 6 - 12

Code: NCT06955338

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

for Pain

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04650841·EARLY_Phase 1

Morphine or Ketamine for Analgesia

for Abdominal Pain

8 sites incl. Los Angeles

Sponsor: Columbia University

Sex: All·Age: 6 - 17

Code: NCT06835504·Phase 3

Integrated Smartphone Technology to Alleviate Malignant Pain (I-STAMP) Testing

for Advanced Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 21+

Code: NCT06117709

Evaluation of Choose to Move Replacement Ready (CTM-RR)

for Osteoarthritis (OA)

Sponsor: University of British Columbia

Sex: All·Age: 50+

Code: NCT07696650

Pain and Smoking Study - Interactive Voice Response

for Smoking

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06442514

Two-Point Versus Single-Point Serratus Anterior Plane Block for Post-Thoracoscopic Surgery Analgesia

for Lung Cancer

Sponsor: Shiyou Wei

Sex: All·Age: 18 - 85

Code: NCT07700823

Screening Protocol

for Pain

1 site in Bethesda

Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Sex: All·Age: 12 - 100·Accepts healthy volunteers

Code: NCT07712874

Mindfulness Intervention on Minimally Invasive Vascular Surgery

for Anxiety

Sponsor: Tongji Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07463638

Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome

for Carpal Tunnel Syndrome (CTS)

Sponsor: Tanta University

Sex: All·Age: 18 - 65

Code: NCT07498998

MucoLock™ for Treatment of Stomatitis

for Stomatitis

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT07506018

Apply to this trial

Effect of 4-7-8 Breathing Technique on Pain and Anxiety During Electromyography in Diabetic Neuropathy

for Diabetic Neuropathies

Sponsor: Nurgül Gün

Sex: All·Age: 18 - 70

Code: NCT07702175

Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy

for Dental Anxiety

Sponsor: Recep Tayyip Erdogan University Training and Research Hospital

Sex: All·Age: 6 - 8·Accepts healthy volunteers

Code: NCT07714915

Optimizing Patient's Comfort During Scleral Indentation

for Pain

Sponsor: University of Alberta

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06683209

The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery

for Pain

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07224711·Phase 4

Cervical Stabilization Exercises IN Subacromial Impingement Syndrome

for Subacromial Impingement Syndrome

Sponsor: Cairo University

Sex: All·Age: 20 - 40

Code: NCT07645781

Registry of Outcomes of Dezawa MuseCells®

for Osteoarthritis (OA)

1 site in North Palm Beach

Sponsor: MuseCell Innovations Pte LTD

Sex: All·Age: Up to 89

Code: NCT07645989

Apply to this trial

Effects of Music Therapy in Chronic Neck Pain

for Neck Pain

Sponsor: Karabuk University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07658729

Effect of Virtual Reality-Guided Imagery on Pain, Anxiety, and Fatigue in Cancer Patients Undergoing Chemotherapy

for Virtual Reality

Sponsor: Thoalfokar Mohammed Al-Obaidi

Sex: Female·Age: 18+

Code: NCT07677436

A Phase IV Randomized Trial of Maxigesic® Versus Standard Analgesia After Radical Gastrectomy

for Stomach Neoplasms

Sponsor: Yonsei University

Sex: All·Age: 20 - 80

Code: NCT07687394·Phase 4

Advancing Patient Care for Lymphatic Pain and Lymphedema

for Breast Cancer

1 site in Kansas City

Sponsor: University of Missouri, Kansas City

Sex: All·Age: 18 - 89

Code: NCT07701018

Active vs. Passive VR During Office-based ENT Procedures

for Pain

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT07599826

Impact of Topical Aromatherapy on Postoperative Quality of Recovery After Lung Resection

for Thoracic Surgical Procedures

Sponsor: University Hospital, Toulouse

Sex: All·Age: 18+

Code: NCT07622602

Green or Pink? A Comparison of Pain and Procedural Difficulty With Intravenous Cannulas in the Emergency Department

for Peripheral Catheterization

Sponsor: Marmara University Pendik Training and Research Hospital

Sex: All·Age: 18+

Code: NCT07629427

A Study of the Impact of a Virtual Reality Medical Device (HypnoVR® Headset) on Anxiety and Pain in Interventional Radiology.

for Anxiety

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07668050

Pain During Infiltration Injection in Anterior Maxillary Region by Transcodent Painless Needle Tips Versus Regular Needle Tips

for Pain

Sponsor: Saidu College of Dentistry

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07703410

A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years

for Pain

1 site in Salt Lake City

Sponsor: HALEON

Sex: All·Age: 6 - 11·Accepts healthy volunteers

Code: NCT07632274·Phase 1

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The Effect of Foot Reflexology in Women With Migraine

for Migraine

Sponsor: Karabuk University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07651839

Use of Hand Extension Rubber During Intravenous Catheter Placement

for Pain

Sponsor: Necmettin Erbakan University

Sex: All·Age: 18 - 65

Code: NCT07659015

Apply to this trial

Efficacy of an Experimental Gel Based on Libidibia Ferrea on Post-bleaching Tooth Sensitivity

for Tooth Bleaching

Sponsor: Universidade Federal do Para

Sex: All·Age: 18 - 40

Code: NCT07599514

Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

for Coronary Disease

1 site in Washington D.C.

Sponsor: Teleflex

Sex: All·Age: 18 - 80

Code: NCT07258290

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Single Ascending Doses (SAD) and Multiple Ascending Doses(MAD) Study of IG001119 in Healthy Adult Participants

for Pain

Sponsor: Iongen Therapeutics Co., Ltd.

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07618247·Phase 1

Virtual Reality for Pain and Anxiety in Pediatric Dental Treatment

for Dental Anxiety in Children

Sponsor: University of British Columbia

Sex: All·Age: 6 - 12·Accepts healthy volunteers

Code: NCT07636330

Interactions Between Placebo Effects and Mindful Awareness State

for Placebo Effect

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07108101

Strength and Pain-Coping Through Resilience and Knowledge

for Pain

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 50+

Code: NCT07228520

Apply to this trial

CABG-AI-Supported Discharge Education

for Coronary Artery Disease

Sponsor: Hasan Kalyoncu University

Sex: All·Age: 18+

Code: NCT07503678

CBD Supplementation in Brazilian Jiu-Jitsu Athletes

for Pro and Anti Inflamatory Cytokines

Sponsor: Associação Pan-Americana Multidisciplinar de Endocanabinologia

Sex: Male·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07552974·Phase 2, Phase 3

Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions

for Pain

Sponsor: University of Rochester

Sex: Female·Age: 18+

Code: NCT07542730·Phase 4

Pain Induced by m-Cresol as Preservative

for Pain

Sponsor: Medical University of Vienna

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07600814·EARLY_Phase 1

The Effect of a Stress Ball During Oral Care Procedures

for Pain

Sponsor: Yuzuncu Yil University

Sex: All·Age: 18+

Code: NCT07676422

Apply to this trial

Effects of a Machine Learning-based Lower Limb Exercise Training System for Knee Pain

for Pain

Sponsor: The University of Hong Kong

Sex: All·Age: 50+

Code: NCT05173064

Efficacy Of Jin's Three-Needle Technique Combined With Electroacupuncture In Cervical Spondylosis With Blood Stasis Syndrome

for Pain

Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City

Sex: All·Age: 18 - 70

Code: NCT07559279

Effect of Helfer Skin Tap and Vibration on Pain and Fear in Children During Intramuscular Injection

for Pain

Sponsor: Ege University

Sex: All·Age: 5 - 12

Code: NCT07468227

Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting

for Wound and Injuries

Sponsor: King Edward Medical University

Sex: All·Age: 20 - 60

Code: NCT07480447

Effects of Stress Ball and Hand Massage on Vital Signs, Anxiety, and Pain During Eye Surgery

for Anxiety

Sponsor: Mehmet Gunay Uyar

Sex: All·Age: 18+

Code: NCT07522034

Safety Evaluation of Bioactive Glass Based Bone Cement Combined With Ultrasound in Implantation for Metastatic Bone Tumors

for Advanced Cancer

Sponsor: Liao Yun

Sex: All·Age: 18 - 80

Code: NCT07540468

Plantar Pressure and Pain in Young Adults

for Young Adult

Sponsor: Fenerbahce University

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07568925

Exercise Induced Hypoalgesia in Pain-free Stroke and Healthy Populations: a Cohort Study

for Stroke

Sponsor: Neuron, Spain

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07327593

Apply to this trial

Translation and Cross-Cultural Adaptation Into French of the COMFORTneo Pain Assessment Tool for Newborns

for Pain

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: All ages

Code: NCT07463170

Creation of a Scale for Assessing Pain and Discomfort in Extremely Premature Infants (EDEX) Hospitalised in Neonatal Intensive Care, Inspired by the Early Infant Pain and Discomfort Scale (EDIN)

for Extremely Premature Infant

Sponsor: Centre Hospitalier Universitaire de la Réunion

Sex: All·Age: Up to 27 Weeks

Code: NCT07481331

Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors

for Psychoneurological Symptom Cluster(Pain, Insomnia, Anxiety, Fatigue, Depression, Subjective Cognitive Decline)

Sponsor: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Sex: Female·Age: 18 - 75

Code: NCT07481903

Effect of Music on Pain and Anxiety During Nail Biopsies

for Procedural Anxiety

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT07518953

Patient Reported Outcome Measurements Registration in Spinal Pathologies and Neuromodulation

for Spinal Pathologies

Sponsor: Jessa Hospital

Sex: All·Age: 18+

Code: NCT07552519

Apply to this trial

Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain

for Pain

1 site in Tallahassee

Sponsor: Florida State University

Sex: All·Age: 18+

Code: NCT07562412

Apply to this trial

Effects of an Experimental Propolis Gel on Tooth Sensitivity Control and Post-bleaching Color Change: a Randomized Clinical Trial

for Tooth Bleaching

Sponsor: Universidade Federal do Para

Sex: All·Age: 18 - 40

Code: NCT07569276

Pain (general) clinical trials — common questions

Are pain (general) clinical trials free to join?

Yes. Participating in a pain (general) clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a pain (general) clinical trial?

Each pain (general) study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a pain (general) trial near me?

Use the location controls above. We'll show recruiting pain (general) trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many pain (general) trials are recruiting right now?

We're currently tracking roughly 133 recruiting pain (general) trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Pain (general) trials by city

Los Angeles, CA Boston, MA Cleveland, OH Indianapolis, IN Gainesville, FL Salt Lake City, UT Aurora, CO Chicago, IL Miami, FL San Francisco, CA Seattle, WA Tallahassee, FL

Related specialties

Pain management