Pain management Clinical Trials

Recruiting pain management studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat pain management. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting pain management studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting pain management trials

Within

Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care

for Chronic Pain

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07456150·Phase 1

Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery

for Postoperative Pain

Sponsor: University of Alexandria

Sex: All·Age: 18 - 65

Code: NCT04110132

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

Mindfulness Therapy for Chronic Pain After Intimate Partner Violence

for Chronic Pain

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07700355

Internet-Delivered ACT Targeting Emotional Distress and Chronic Pain

for Chronic Pain

Sponsor: Skane University Hospital

Sex: All·Age: 18 - 65

Code: NCT07426367

Therapeutic Exercise and Education for Low Back Pain

for Low Back Pain

Sponsor: University of Valladolid

Sex: All·Age: 18+

Code: NCT07713082

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

for Distal Radius Fracture

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05318729

FIBROmyalgia: Somatic Tracking and Exercise Program Study

for Fibromyalgia (FM)

Sponsor: University of Tromso

Sex: All·Age: 18 - 65

Code: NCT06922747

Study of QL Analgesic Response and Extent

for Acute Pain

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07566312·Phase 4

Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement

for Vasoconstriction

Sponsor: diana garcia

Sex: All·Age: 18+

Code: NCT07696156

AI and Computer Vision-Assisted Telerehabilitation in Fibromyalgia: The FibroIA 2.0 Trial

for Fibromyalgia

Sponsor: Instituto Neurociencia Del Dolor

Sex: All·Age: 18+

Code: NCT07674485

Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME)

for Postoperative Pain

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07624006·Phase 4

Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care

for Trismus

Sponsor: Allama Iqbal Medical College

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07719270

Intertransverse Process Block Versus Subcostal Transversus Abdominis Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591129

Intertransverse Process Block Versus External Oblique Intercostal Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591116

Context Interventions: Social Modeling and Initial Treatment Experience

for Placebo Effect

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04646460

Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain

for Fibromyalgia

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT05569486

Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children

for Anxiety

Sponsor: Ege University

Sex: All·Age: 6 - 12

Code: NCT06955338

Comparison of Serratus Posterior Superior Intercostal Plane Block and Deep Serratus Anterior Plane Block After Video-Assisted Thoracoscopic Surgery

for Postoperative Pain

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553195

Transversalis Fascia Plane Block Versus M-TAPA Block After Laparoscopic Inguinal Hernia Repair

for Transversalis Fascia Plane Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07619053

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07599787

Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: Female·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06280989

SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery

for Rib Fracture

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553208

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07589491

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

for Opioid Use Disorder

4 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07361432·Phase 3

Simultaneous Engagement of Networks for Alleviating Pain (SENAP)

for Neuropathic Pain

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 22+

Code: NCT07057206·Phase 1

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

Apply to this trial

Empowered Relief for Caregivers

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07636980

Advancing Online Psychology Tools for Chronic Pain

for Fibromyalgia

Sponsor: Women's College Hospital

Sex: All·Age: 18+

Code: NCT07659873

taVNS Treatment for Fibromyalgia

for Fibromyalgia

1 site in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04777500

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy

for Cerebral Palsy (CP)

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07585292

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury

for Spinal Cord Injury

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07588711

The Women Veteran's Health Mission

for Chronic Pain

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07608952

Development of a Pain Rehabilitation Program for Chronic Pain After SCI

for Spinal Cord Injuries

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634796

Postoperative Pain and Tenesmus After Doppler-Guided Hemorrhoidal Artery Ligation With or Without Mucopexy

for Postoperative Pain

Sponsor: Ali Genc

Sex: All·Age: 18+

Code: NCT07710053

Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain

for Low Back Pain

Sponsor: Universidad de Zaragoza

Sex: All·Age: 35 - 65

Code: NCT06527339

Jaw Muscle Pain Post Wisdom Molar Surgery

for Post Operative Pain

1 site in Newark

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 18+

Code: NCT07094542·Phase 2

Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System

for Pain Measurement

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18+

Code: NCT07322900

Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy

for Chronic Pain

Sponsor: Universidad Autonoma de Madrid

Sex: All·Age: 18+

Code: NCT07451587

The Effectiveness of High-intensity Laser Therapy on Post-surgical Rehabilitation After Total Knee Arthroplasty

for Arthroplasty Complications

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 50 - 80

Code: NCT07568262

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

for Fibromyalgia

Sponsor: Hospital Ambroise Paré Paris

Sex: All·Age: 18 - 80

Code: NCT07642882

Apply to this trial

Multidisciplinary Health Monitoring for Esports Players

for Musculoskeletal Pain

Sponsor: Yeditepe University

Sex: Male·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07665333

Recovery With Virtual Reality for Stress and Pain

for Preoperative Anxiety

Sponsor: Region Skane

Sex: All·Age: 18+

Code: NCT07679022

Daily, Encapsulated, Green Tea Extract to Mitigate Neuropathic Pain in Patients With Established Cancer-Associated Neuropathic Pain

for Neuropathic Pain

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07682324·Phase 2

Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain

for Low Back Pain

Sponsor: Axon srl

Sex: All·Age: 25+

Code: NCT07696507

The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation

for Low Back Pain

Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy

Sex: All·Age: 18 - 50

Code: NCT07626294

SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients

for Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine

Sponsor: juan jose valero quintero,MD

Sex: All·Age: 18 - 100

Code: NCT07693517

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

for Pain

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04650841·EARLY_Phase 1

Morphine or Ketamine for Analgesia

for Abdominal Pain

8 sites incl. Los Angeles

Sponsor: Columbia University

Sex: All·Age: 6 - 17

Code: NCT06835504·Phase 3

OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis

for Multiple Sclerosis

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 65

Code: NCT07221799·Phase 1

Analgesic Effect of a Biophotonic Foot Massage Cream

for Musculoskeletal Pain

Sponsor: University of Seville

Sex: All·Age: 18+

Code: NCT07501273

Efficacy of Spinal Cord Stimulation in Chemotherapy-Induced Peripheral Neuropathy

for Neuropathic Pain

Sponsor: Assistance Publique Hopitaux De Marseille

Sex: All·Age: 18 - 100

Code: NCT07579611

Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches

for Neuropathic Pain

Sponsor: Nantes University Hospital

Sex: All·Age: 18+

Code: NCT07660510

Timing of Serratus Anterior Plane Block in Mastectomy Surgery

for Quality of Recovery After Mastectomy

Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Sex: Female·Age: 18+

Code: NCT07661212

Validation of the Turkish Brief Inventory of Treatment Expectations in Chronic Pain

for Chronic Pain

Sponsor: Hacettepe University

Sex: All·Age: 18 - 70

Code: NCT07673874

Turkish Adaptation of the Pain and Smoking Inventory

for Chronic Pain

Sponsor: Hacettepe University

Sex: All·Age: 18 - 65

Code: NCT07673926

Integrated Smartphone Technology to Alleviate Malignant Pain (I-STAMP) Testing

for Advanced Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 21+

Code: NCT06117709

Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds

for Spinal Disease

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06792474·Phase 4

Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain

for Neuropathic Pain

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 5 - 26

Code: NCT07264920

Pain management clinical trials — common questions

Are pain management clinical trials free to join?

Yes. Participating in a pain management clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a pain management clinical trial?

Each pain management study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a pain management trial near me?

Use the location controls above. We'll show recruiting pain management trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many pain management trials are recruiting right now?

We're currently tracking roughly 547 recruiting pain management trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Pain management trials by city

Boston, MA Chicago, IL Los Angeles, CA Birmingham, AL Ann Arbor, MI Cleveland, OH San Francisco, CA Gainesville, FL Indianapolis, IN Palo Alto, CA San Diego, CA Irvine, CA

Conditions in this area

Chronic pain Pain (general)Postoperative pain Low back pain Neuropathic pain Musculoskeletal pain Fibromyalgia