Pain management Clinical Trials

Recruiting pain management studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat pain management. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting pain management studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting pain management trials

Within

Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care

for Chronic Pain

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07456150·Phase 1

Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery

for Postoperative Pain

Sponsor: University of Alexandria

Sex: All·Age: 18 - 65

Code: NCT04110132

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

Psilocybin After Trauma Surgery for Pain

for Pain Management

1 site in Pittsburgh

Sponsor: Trent Emerick

Sex: All·Age: 25 - 65

Code: NCT07406828·Phase 1

ESP Blocks for Posterior Spinal Fusion

for Postoperative Pain

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07228039·Phase 4

Mindfulness Therapy for Chronic Pain After Intimate Partner Violence

for Chronic Pain

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07700355

DockTales for Chronic Pain

for Chronic Pain

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 88

Code: NCT07680894

Optimizing Patient's Comfort During Scleral Indentation

for Pain

Sponsor: University of Alberta

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06683209

Internet-Delivered ACT Targeting Emotional Distress and Chronic Pain

for Chronic Pain

Sponsor: Skane University Hospital

Sex: All·Age: 18 - 65

Code: NCT07426367

Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain

for Stress Disorders, Post-Traumatic

1 site in San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07725588

Therapeutic Exercise and Education for Low Back Pain

for Low Back Pain

Sponsor: University of Valladolid

Sex: All·Age: 18+

Code: NCT07713082

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement

for Pain

Sponsor: Henry Ford Health System

Sex: All·Age: 18+

Code: NCT07741201

MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease

for Chronic Pain

Sponsor: University of Illinois at Chicago

Sex: All·Age: 15 - 39

Code: NCT07797582

Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain

for Pain

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07783672

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

for Distal Radius Fracture

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05318729

FIBROmyalgia: Somatic Tracking and Exercise Program Study

for Fibromyalgia (FM)

Sponsor: University of Tromso

Sex: All·Age: 18 - 65

Code: NCT06922747

Study of QL Analgesic Response and Extent

for Acute Pain

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07566312·Phase 4

A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery

for Postoperative Pain

Sponsor: Chaw Sook Hui

Sex: All·Age: 18 - 75

Code: NCT07803575

Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement

for Vasoconstriction

Sponsor: diana garcia

Sex: All·Age: 18+

Code: NCT07696156

AI and Computer Vision-Assisted Telerehabilitation in Fibromyalgia: The FibroIA 2.0 Trial

for Fibromyalgia

Sponsor: Instituto Neurociencia Del Dolor

Sex: All·Age: 18+

Code: NCT07674485

The Role of Virtual Reality During Regional Anesthesia

for Anxiety

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT04163809

CBD Supplementation in Brazilian Jiu-Jitsu Athletes

for Pro and Anti Inflamatory Cytokines

Sponsor: Associação Pan-Americana Multidisciplinar de Endocanabinologia

Sex: Male·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07552974·Phase 2, Phase 3

Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME)

for Postoperative Pain

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07624006·Phase 4

Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care

for Trismus

Sponsor: Allama Iqbal Medical College

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07719270

Intertransverse Process Block Versus Subcostal Transversus Abdominis Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591129

Intertransverse Process Block Versus External Oblique Intercostal Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591116

Context Interventions: Social Modeling and Initial Treatment Experience

for Placebo Effect

1 site in Hanover

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04646460

Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain

for Fibromyalgia

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT05569486

Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children

for Anxiety

Sponsor: Ege University

Sex: All·Age: 6 - 12

Code: NCT06955338

A Comparison Between The Efficacy of Modified Thoracoabdominal Plane Block Via Perichondral Approach (M-TAPA) And External Oblique Intercostal Plane Block (EOIPB) in Patients Undergoing Laparoscopic Cholecystectomy Surgeries (LC)

for Post Operative Pain

Sponsor: Kasr El Aini Hospital

Sex: All·Age: 18 - 65

Code: NCT06810206

Comparison of Serratus Posterior Superior Intercostal Plane Block and Deep Serratus Anterior Plane Block After Video-Assisted Thoracoscopic Surgery

for Postoperative Pain

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553195

Transversalis Fascia Plane Block Versus M-TAPA Block After Laparoscopic Inguinal Hernia Repair

for Transversalis Fascia Plane Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07619053

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07599787

Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: Female·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06280989

SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery

for Rib Fracture

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553208

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07589491

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

for Opioid Use Disorder

4 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07361432·Phase 3

Simultaneous Engagement of Networks for Alleviating Pain (SENAP)

for Neuropathic Pain

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 22+

Code: NCT07057206·Phase 1

SPENG Block Versus Suprascapular and Axillary Nerve Blocks for Pain After Shoulder Arthroscopy

for Postoperative Pain

Sponsor: Izmir City Hospital

Sex: All·Age: 18 - 70

Code: NCT07762417

Single vs Multiple Injection Intertransverse Process Block in Breast Cancer Surgery

for Breast Cancer

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07763756

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

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The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery

for Pain

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07224711·Phase 4

Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain

for Neuropathic Pain

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 5 - 26

Code: NCT07264920

Empowered Relief for Caregivers

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07636980

Advancing Online Psychology Tools for Chronic Pain

for Fibromyalgia

Sponsor: Women's College Hospital

Sex: All·Age: 18+

Code: NCT07659873

CODEPAD-III (Collaborative Outcomes of DEpression and Pain Associated With Delivery-III)

for Depression

Sponsor: KK Women's and Children's Hospital

Sex: All·Age: 21+

Code: NCT07773259

Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT

for Chronic Pain

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 120·Accepts healthy volunteers

Code: NCT07785648

taVNS Treatment for Fibromyalgia

for Fibromyalgia

1 site in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04777500

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy

for Cerebral Palsy (CP)

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07585292

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury

for Spinal Cord Injury

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07588711

The Women Veteran's Health Mission

for Chronic Pain

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07608952

Development of a Pain Rehabilitation Program for Chronic Pain After SCI

for Spinal Cord Injuries

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634796

Postoperative Pain and Tenesmus After Doppler-Guided Hemorrhoidal Artery Ligation With or Without Mucopexy

for Postoperative Pain

Sponsor: Ali Genc

Sex: All·Age: 18+

Code: NCT07710053

Impact of the Receptive Music Intervention Tool (MUSIC CARE©) on Changes in the Functional Abilities of Patients With Chronic Low Back Pain

for Low Back Pain

Sponsor: LNA SANTE

Sex: All·Age: 18+

Code: NCT07731204

Impact of Probiotics on Neuropathy Induced by Adjuvant Chemotherapy in Patients With Colon Cancer.

for Colon Adenocarcinoma

Sponsor: Centre Francois Baclesse

Sex: All·Age: 18+

Code: NCT07733817

eMindExCare for Prostate Cancer Patients Undergoing Active Treatment

for Prostate Cancer

Sponsor: The University of Hong Kong

Sex: Male·Age: 18+

Code: NCT07735273

Perioperative Yoga Therapy and Endometriosis Surgery

for Endometriosis

Sponsor: University Hospital, Lille

Sex: Female·Age: 18+

Code: NCT07765680

Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)

for Low Back Pain

1 site in Valhalla

Sponsor: New York Medical College

Sex: All·Age: 18+

Code: NCT07772154

Remote Assessment of Pain and Recovery Quality After Surgery Using a Digital Form: A Pilot Study

for Remote Monitoring of Pain and Recovery Quality in the Immediate Postoperative Period Using a Digital Health Tool

Sponsor: Hospital de Base

Sex: All·Age: 18+

Code: NCT07794267

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Pain management clinical trials — common questions

Are pain management clinical trials free to join?

Yes. Participating in a pain management clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a pain management clinical trial?

Each pain management study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a pain management trial near me?

Use the location controls above. We'll show recruiting pain management trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many pain management trials are recruiting right now?

We're currently tracking roughly 547 recruiting pain management trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Pain management trials by city

Boston, MA Los Angeles, CA Chicago, IL Birmingham, AL Ann Arbor, MI San Francisco, CA Gainesville, FL Cleveland, OH Indianapolis, IN Palo Alto, CA San Diego, CA Stanford, CA

Conditions in this area

Chronic pain Pain (general)Postoperative pain Low back pain Neuropathic pain Musculoskeletal pain Fibromyalgia