Sarcoma Clinical Trials

Recruiting sarcoma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat sarcoma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting sarcoma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting sarcoma trials

Within

Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial

for High Grade Sarcoma

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: All ages

Code: NCT07650656·Phase 2

Apply to this trial

Information-providing Chatbot

for Sarcoma

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 18+

Code: NCT07505732

Bone Arches: Performance of Pseudo-scanner Sequences in Segmenting the Extent of the Tumour and in Planning Surgical Resection Using the CT Scan as a Reference

for Sarcoma

Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Sex: All·Age: 18+

Code: NCT06988007

Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

for Sarcoma

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 65 - 100

Code: NCT07125183·Phase 2

Apply to this trial

Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma

for Febrile Neutropenia

Sponsor: Shaare Zedek Medical Center

Sex: All·Age: 18 - 65

Code: NCT06500715

Comparison of the Effects of Needle Biopsy Tract Resection and Non-resection on Recurrence Rate in Patients With Primary Extremity Sarcoma

for Primary

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 5+

Code: NCT07575724·Phase 2

Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas

for MPNST

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 99

Code: NCT05253131·Phase 2

Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study

for Gastrointestinal Neoplasms

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07389525·EARLY_Phase 1

Effect of Hypnosis in the Management of Anxiety and Chemo-induced Symptoms in Adolescents and Young Adults With Sarcoma or Germ Cell Tumor and in Young Women With Breast Cancer

for Sarcoma

Sponsor: Institut Bergonié

Sex: All·Age: 15 - 49

Code: NCT07614620

my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults

for Sarcoma

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15 - 24

Code: NCT07516353

Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot Intervention

for Sarcoma

3 sites in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15 - 39

Code: NCT07662239

Combination Immunotherapy Targeting Sarcomas

for Sarcoma

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 1 - 75

Code: NCT04433221·Phase 1, Phase 2

Apply to this trial

Study of Preoperative RAdiation Therapy With Concomitant Liposomal Transcrocetin (L-TC) in Soft tISsue Sarcomas

for Sarcoma

Sponsor: Centre Paul Strauss

Sex: All·Age: 18+

Code: NCT06476704·Phase 2

CD70.CAR for CD70+ Lymphoma, Myeloma and Solid Tumors

for Lymphoma

2 sites in Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 0 - 75

Code: NCT07297160·Phase 1

A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)

for Sarcoma

Sponsor: GlaxoSmithKline

Sex: All·Age: All ages

Code: NCT07602777·Phase 1, Phase 2

Apply to this trial

Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas

for Sarcoma

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 1 - 75

Code: NCT03356782·Phase 1, Phase 2

Apply to this trial

Radiographic Evaluation of Tumor Biology During Neoadjuvant Radiotherapy for Sarcoma

for Sarcoma

1 site in Cincinnati

Sponsor: Andrew Frankart

Sex: All·Age: 18+

Code: NCT07487870

The Safety, Dosimetry and Efficacy of 177Lu-INN805 in Patients With Malignant Solid Tumors

for Maligant Solid Tumor

Sponsor: FindCure Biosciences (ZhongShan) Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07459283·EARLY_Phase 1

Tumor-Lymph Node Mapping

for Pediatric Solid Tumors

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 1 Month - 17

Code: NCT07054944

Apply to this trial

Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant Tumors

for Pancreatic Cancer

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07552467

Apply to this trial

BOLD-100 Plus Doxorubicin in Advanced Soft Tissue Sarcomas

for Sarcoma, Soft-tissue

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07027423·Phase 1

Brief Title Mechanisms of Cancer-Related Pain and Opioid Use Among Adolescents and Young Adult Sarcoma Survivors: Pilot Feasibility Study

for Sarcoma

1 site in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 12 - 70

Code: NCT07402577

Apply to this trial

Preoperative Spatially Fractionated Radiation Therapy (SFRT) in Soft Tissue Sarcoma (neoSFRT-SARC)

for Sarcoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18 - 75

Code: NCT07501026·Phase 2

Apply to this trial

Navigation Intervention for Adolescent and Young Adult Cancer Survivors

for Breast Cancer

1 site in Pasadena

Sponsor: Kaiser Permanente

Sex: All·Age: 21 - 45

Code: NCT07406087

Apply to this trial

Distance-Based Exercise to Preserve Function and Prevent Disability

for Localized Malignant Solid Neoplasm

18 sites incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884

Apply to this trial

Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients

for Sarcoma

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 12 - 39

Code: NCT07359911

Apply to this trial

EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors

for Cancer

Sponsor: Essen Biotech

Sex: All·Age: All ages

Code: NCT07410676·Phase 1, Phase 2

Apply to this trial

Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

for Sarcoma

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT07222735·Phase 1

Apply to this trial

MAGNATE-S: Paclitaxel Polymer Micelles Combo in Advanced Sarcoma

for Sarcoma

Sponsor: Shanghai 6th People's Hospital

Sex: All·Age: 12 - 70

Code: NCT07359053·Phase 2

Apply to this trial

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

for Breast Cancer

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07447050·Phase 2

Apply to this trial

Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas

for Sarcoma of Soft Tissue

Sponsor: The Netherlands Cancer Institute

Sex: All·Age: 18+

Code: NCT07071727

Apply to this trial

A Study of Pembrolizumab in People With Ultra-Rare Sarcomas

for Sarcoma

6 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07089992·Phase 2

Apply to this trial

Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing

for Sarcoma

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 16+

Code: NCT07048184·Phase 2

Quality of Life and Medical Care of Long-term Sarcoma Survivors in Germany (PROSa+)

for Sarcoma

Sponsor: Technische Universität Dresden

Sex: All·Age: 18+

Code: NCT07148193

Apply to this trial

Pediatric Radiation Therapy Registry

for Sarcoma

2 sites incl. Washington D.C.

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 0 - 26

Code: NCT07129317

Apply to this trial

Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.

for Non-Small Cell Lung Cancer

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07192068·Phase 2

Apply to this trial

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

18 sites incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000

Apply to this trial

Preventive Application of Single-use Negative Pressure Wound Therapy (sNPWT) in the Postoperative Course of Radiotreatated Limb Sarcoma Surgery

for Sarcoma

Sponsor: Istituto Oncologico Veneto IRCCS

Sex: All·Age: 18 - 99

Code: NCT06941194

Apply to this trial

Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma

for Leiomyosarcoma

1 site in Columbus

Sponsor: Gabriel Tinoco

Sex: All·Age: 18+

Code: NCT06528769·Phase 2

Apply to this trial

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

for Sarcoma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06503146·Phase 2

Apply to this trial

A Trial of ABSK043, an Oral PD-L1 Inhibitor, in Patients With Angiogenic Sarcomas

for Sarcoma

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07014137·Phase 2

Apply to this trial

Fluorescence-Guided Optimization of Sarcoma Margins

for Soft Tissue Sarcoma of the Trunk and Extremities

Sponsor: University of Aarhus

Sex: All·Age: 18+

Code: NCT07134192

Apply to this trial

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

for Metastatic Sarcoma

5 sites incl. Duarte

Sponsor: Lantheus Medical Imaging

Sex: All·Age: 15+

Code: NCT06298916·Phase 1, Phase 2

Apply to this trial

IDOV-Immune for Advanced Solid Tumors

for Colorectal Cancer

3 sites incl. St Louis

Sponsor: ViroMissile, Inc.

Sex: All·Age: 18+

Code: NCT06910657·Phase 1

Apply to this trial

LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy in Sarcoma Patients

for Sarcoma

2 sites incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: All ages

Code: NCT06958107

Apply to this trial

A Study to Determine the Safety and Effectiveness of the Investigational Cellular Therapy GCAR1 in a Patient With Alveolar Soft Part Sarcoma

for Alveolar Soft Part Sarcoma (ASPS)

Sponsor: University of Calgary

Sex: Male·Age: All ages

Code: NCT07104682·EARLY_Phase 1

Salutare One Referral Software Impact on Multi-Disciplinary Team (MDT) Meetings Effectiveness and Safety

for Cancer (Solid Tumors)

Sponsor: Salutare Group Ltd.

Sex: All·Age: All ages

Code: NCT07104955

Apply to this trial

WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)

for Lymphoma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07058064

Apply to this trial

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

for Cancer

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 39

Code: NCT06371768

Apply to this trial

PROMIS and Mobility Evaluation in Sarcoma Patients

for Sarcoma

2 sites incl. Phoenix

Sponsor: University of Calgary

Sex: All·Age: 18+

Code: NCT07227961

Apply to this trial

Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas

for Sarcoma

Sponsor: Essen Biotech

Sex: All·Age: 21 - 90

Code: NCT07066982·Phase 1, Phase 2

Apply to this trial

An Open-label, Phase I Clinical Trial of Super1 TCR-T in NY-ESO-1-positive Patients With Advanced Solid Tumors

for Sarcoma

Sponsor: Guangzhou FineImmune Biotechnology Co., LTD.

Sex: All·Age: 18 - 75

Code: NCT06942143·Phase 1

Apply to this trial

SLV-154 Treatment of Metastatic Solid Tumors

for Squamous Cell Cancer of Head and Neck (SCCHN)

10 sites incl. Newport Beach

Sponsor: Solve Therapeutics

Sex: All·Age: 18+

Code: NCT06771219·Phase 1

Apply to this trial

Evaluating the Use of Educational Videos in Newly Diagnosed Patients in a Medical Oncology Sarcoma Clinic

for Sarcoma

Sponsor: Mount Sinai Hospital, Canada

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06805773

Apply to this trial

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas

for Solid Tumor

9 sites incl. San Francisco

Sponsor: STORM Therapeutics LTD

Sex: All·Age: 18+

Code: NCT06975293·Phase 1, Phase 2

Apply to this trial

Lead-212 PSV359 Therapy for Patients With Solid Tumors

for Pancreatic Ductal Adenocarcinoma

11 sites incl. Miami

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06710756·Phase 1, Phase 2

Apply to this trial

Clonal Hematopoiesis Chemotherapy and Radiation Effects Study

for Lung Cancer (Diagnosis)

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07675967

Apply to this trial

Lipid Mediators & Cancer: Montelukast, SPM, and Almonds

for Colorectal Cancer

2 sites in Tampa

Sponsor: University of South Florida

Sex: All·Age: 18+

Code: NCT06887673·EARLY_Phase 1

NY-ESO-1-redirected T Cells in Patients With Advanced Melanoma and Sarcoma

for Advanced Melanoma

Sponsor: Centre Hospitalier Universitaire Vaudois

Sex: All·Age: 18+

Code: NCT06889766·Phase 1

Apply to this trial

Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma

for Adult Pleomorphic Rhabdomyosarcoma

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 1 - 85

Code: NCT06526897

Sarcoma clinical trials — common questions

Are sarcoma clinical trials free to join?

Yes. Participating in a sarcoma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a sarcoma clinical trial?

Each sarcoma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a sarcoma trial near me?

Use the location controls above. We'll show recruiting sarcoma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many sarcoma trials are recruiting right now?

We're currently tracking roughly 71 recruiting sarcoma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Sarcoma trials by city

Boston, MA Duarte, CA Birmingham, AL Los Angeles, CA Miami, FL Orange, CA Santa Monica, CA Aurora, CO Beverly Hills, CA Chicago, IL Cincinnati, OH Columbus, OH

Related specialties

Oncology