Paid Clinical Trials in Greenville, SC
As of July 2026, 265 paid clinical trials are recruiting in Greenville, South Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Greenville offers studies at sites including Prisma Health Cancer Institute - Eastside for conditions such as Acute Myeloid Leukemia, Breast Cancer, Advanced Solid Tumor, Malignant Solid Neoplasm. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Greenville
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Researchers run research studies in Greenville, SC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Prisma Health Cancer Institute - Eastside | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 49 |
| Prisma Health Cancer Institute - Faris | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 49 |
| Prisma Health Cancer Institute - Butternut | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 44 |
| BI-LO Charities Children's Cancer Center | B Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Down Syndrome | 29 |
| Prisma Health | End Stage Renal Disease, Intracranial Aneurysm, AML | 24 |
| Saint Francis Cancer Center | Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma, Lung Non-Small Cell Carcinoma | 22 |
| Prisma Health Greenville Memorial Hospital | Malignant Solid Neoplasm, Acute Decompensated Heart Failure, Acute Lymphoblastic Leukemia | 21 |
| Saint Francis Hospital | Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma, Lung Non-Small Cell Carcinoma | 20 |
| Prisma Health Cancer Institute | Advanced Melanoma, Advanced Solid Tumor, Amyloid Cardiomyopathy | 8 |
| Prisma Health - Upstate | Acute Myocardial Infarction, Acute Stroke, Chronic Disease | 8 |
| Prisma Health-Upstate | AAA - Abdominal Aortic Aneurysm, AV Block, Advanced Solid Tumor | 7 |
| Tribe Clinical Research, LLC | Obesity, Overweight, Atopic Dermatitis | 6 |
| Prisma Health Upstate | Acute Limb Ischemia, Chronic Graft-versus-host-disease, Diastolic Heart Failure | 5 |
| PCPMG Clinical Research Unit, LLC | Chronic Pain, Chronic Leg Pain, Chronic Low-back Pain | 4 |
| Premier Neurology | Multiple Sclerosis (MS) Primary Progressive, Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis | 4 |
| Greenwood Genetic Center - Greenville | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 4 |
| Prisma Health- Upstate | Articular Fractures, Chronic Renal Disease, End Stage Renal Disease (ESRD) | 3 |
| GSK Investigational Site | Chickenpox, Pulmonary Disease, Chronic Obstructive | 2 |
| Gastroenterology Associates | Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis | 2 |
| Gastroenterology Associates - Patewood | Obesity or Overweight, Crohn's Disease, Ulcerative Colitis | 2 |
| Greenville Memorial Hospital | Alcohol Use Disorder, Symptomatic Hypertrophic Cardiomyopathy (HCM) | 2 |
| Palmetto Clinical Trial Services, LLC | Actinic Keratosis | 2 |
| Retina Consultants of Carolina | Age-related Macular Degeneration (AMD), Choroidal Melanoma, Geographic Atrophy (GA) | 2 |
| Steadman Hawkins Clinic of the Carolinas | Ankylosing Spondylitis, Fracture, Infections | 2 |
| Tribe Clinical Research LLC | Cardiovascular Diseases, Chronic Spontaneous Urticaria (CSU), Diabetes Mellitus, Type 2 | 2 |
Active & Upcoming Studies in Greenville (2026)
Recruiting trials in Greenville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (102 active studies)
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
- A Phase 1 Study of the Safety and Tolerability of CTX-10726 · Phase 1 · Compass Therapeutics
Neurology & pain (16 active studies)
- Continuous Dual Aspiration Technique With Zoom System for Stroke · Imperative Care, Inc.
- A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis · Phase 3 · Zenas BioPharma (USA), LLC
Diabetes & metabolic (15 active studies)
- A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin · Phase 3 · AstraZeneca
- A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight · Phase 2 · Eli Lilly and Company
Cardiovascular (12 active studies)
- Implementation Facilitation of Exercise is Medicine Greenville · University of South Carolina
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
Mental health & behavior (4 active studies)
- Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine · Prisma Health-Upstate
- STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking · Medical University of South Carolina
Vaccines (3 active studies)
- A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose · Phase 3 · Pfizer
- A Study of BLB-201 RSV Vaccine in Infants and Children · Phase 1, Phase 2 · Blue Lake Biotechnology Inc.
Eye & vision (3 active studies)
- COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio · Phase 2 · Apellis Pharmaceuticals, Inc.
Pediatric (1 active study)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
Common conditions studied in Greenville
- Acute Myeloid Leukemia (9 active studies)
- Breast Cancer (7 active studies)
- Advanced Solid Tumor (5 active studies)
- Cancer (5 active studies)
- Malignant Solid Neoplasm (5 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (4 active studies)
Leading research sponsors in Greenville
- National Cancer Institute (NCI)
- Children's Oncology Group
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Greenville?
There are approximately 265 recruiting clinical trials in Greenville, South Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Greenville pay participants?
Most recruiting trials in Greenville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Greenville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Greenville?
The most common conditions under active study in Greenville include Acute Myeloid Leukemia (9), Breast Cancer (7), Advanced Solid Tumor (5), Cancer (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Greenville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Greenville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Greenville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Greenville?
Recruiting research sites in Greenville include Prisma Health Cancer Institute - Eastside, Prisma Health Cancer Institute - Faris, Prisma Health Cancer Institute - Butternut, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Greenville right now?
The largest active categories in Greenville are Cancer & tumors (102), Neurology & pain (16), Diabetes & metabolic (15). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.