Oncology Clinical Trials in Greenville, SC
As of July 2026, 65 paid clinical trials are recruiting for Oncology in Greenville, South Carolina. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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65 clinical trials for Oncology
·Clear filters·↓ Download CSVA Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML
Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
A Phase 1 Study of the Safety and Tolerability of CTX-10726
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors
A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors
First in Human, Dose Escalation Study of AN4005
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Mobile Health for Adherence in Breast Cancer Patients
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
E-Mindfulness Approaches for Living After Breast Cancer
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)
Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
About research studies in Greenville
Greenville has approximately 267 recruiting research studies across a wide range of therapeutic areas. South Carolina hosts a diverse network of universities, academic medical centers, and community hospitals that run clinical trials across oncology, cardiology, neurology, and many other therapeutic areas.
Top Research Study Locations in Greenville
Researchers run research studies in Greenville, SC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Prisma Health Cancer Institute - Eastside | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 49 |
| Prisma Health Cancer Institute - Faris | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 49 |
| Prisma Health Cancer Institute - Butternut | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 43 |
| BI-LO Charities Children's Cancer Center | B Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Down Syndrome | 30 |
| Prisma Health | End Stage Renal Disease, Intracranial Aneurysm, AML | 24 |
| Saint Francis Cancer Center | Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma, Lung Non-Small Cell Carcinoma | 22 |
| Prisma Health Greenville Memorial Hospital | Malignant Solid Neoplasm, Acute Decompensated Heart Failure, Acute Lymphoblastic Leukemia | 21 |
| Saint Francis Hospital | Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma, Lung Non-Small Cell Carcinoma | 20 |
| Prisma Health Cancer Institute | Advanced Melanoma, Advanced Solid Tumor, Amyloid Cardiomyopathy | 8 |
| Prisma Health - Upstate | Acute Myocardial Infarction, Acute Stroke, Chronic Disease | 8 |
| Prisma Health-Upstate | AAA - Abdominal Aortic Aneurysm, AV Block, Advanced Solid Tumor | 7 |
| Tribe Clinical Research, LLC | Obesity, Overweight, Atopic Dermatitis | 6 |
| Prisma Health Upstate | Acute Limb Ischemia, Chronic Graft-versus-host-disease, Diastolic Heart Failure | 5 |
| PCPMG Clinical Research Unit, LLC | Chronic Pain, Chronic Leg Pain, Chronic Low-back Pain | 4 |
| Greenwood Genetic Center - Greenville | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 4 |
| Premier Neurology | Multiple Sclerosis (MS) Primary Progressive, Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis (SPMS) | 4 |
| Prisma Health- Upstate | Articular Fractures, Chronic Renal Disease, End Stage Renal Disease (ESRD) | 3 |
| Gastroenterology Associates | Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis | 2 |
| Gastroenterology Associates - Patewood | Obesity or Overweight, Crohn's Disease, Ulcerative Colitis | 2 |
| Greenville Memorial Hospital | Alcohol Use Disorder, Symptomatic Hypertrophic Cardiomyopathy (HCM) | 2 |
| Palmetto Clinical Trial Services, LLC | Actinic Keratosis | 2 |
| Retina Consultants of Carolina | Age-related Macular Degeneration (AMD), Choroidal Melanoma, Geographic Atrophy (GA) | 2 |
| Steadman Hawkins Clinic of the Carolinas | Ankylosing Spondylitis, Fracture, Infections | 2 |
| Tribe Clinical Research LLC | Cardiovascular Diseases, Chronic Spontaneous Urticaria (CSU), Diabetes Mellitus, Type 2 | 2 |
| Addiction Medicine Center | Sweet Non-cooling EC, Sweet-Cooling EC, Tobacco-flavored EC | 1 |
Active & Upcoming Studies in Greenville (2026)
Recruiting trials in Greenville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (103 active studies)
- A Phase 1 Study of the Safety and Tolerability of CTX-10726 · Phase 1 · Compass Therapeutics
- Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII · Phase 2 · Black Diamond Therapeutics, Inc.
Diabetes & metabolic (17 active studies)
- A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin · Phase 3 · AstraZeneca
- A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight · Phase 2 · Eli Lilly and Company
Neurology & pain (16 active studies)
- Continuous Dual Aspiration Technique With Zoom System for Stroke · Imperative Care, Inc.
- A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis · Phase 3 · Zenas BioPharma (USA), LLC
Cardiovascular (12 active studies)
- Implementation Facilitation of Exercise is Medicine Greenville · University of South Carolina
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
Mental health & behavior (4 active studies)
- Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine · Prisma Health-Upstate
- STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking · Medical University of South Carolina
Vaccines (3 active studies)
- A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose · Phase 3 · Pfizer
- A Study of BLB-201 RSV Vaccine in Infants and Children · Phase 1, Phase 2 · Blue Lake Biotechnology Inc.
Eye & vision (3 active studies)
- COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio · Phase 2 · Apellis Pharmaceuticals, Inc.
Pediatric (1 active study)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
Common conditions studied in Greenville
- Acute Myeloid Leukemia (9 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Breast Cancer (7 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Advanced Solid Tumor (5 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Cancer (5 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Malignant Solid Neoplasm (5 active studies). Recruiting Malignant Solid Neoplasm studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Obesity (5 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
Leading research sponsors in Greenville
- National Cancer Institute (NCI)
- Children's Oncology Group
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- NRG Oncology
Local regulations and guidelines
Clinical trials in South Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. South Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Greenville. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Greenville
Hipa.ai aggregates every recruiting study in Greenville from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Greenville?
There are approximately 267 recruiting clinical trials in Greenville, South Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Greenville pay participants?
Most recruiting trials in Greenville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Greenville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Greenville?
The most common conditions under active study in Greenville include Acute Myeloid Leukemia (9), Breast Cancer (7), Advanced Solid Tumor (5), Cancer (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Greenville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Greenville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Greenville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Greenville?
Recruiting research sites in Greenville include Prisma Health Cancer Institute - Eastside, Prisma Health Cancer Institute - Faris, Prisma Health Cancer Institute - Butternut, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Greenville right now?
The largest active categories in Greenville are Cancer & tumors (103), Diabetes & metabolic (17), Neurology & pain (16). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.