Oncology Clinical Trials in Lexington, KY
As of August 2026, 95 paid clinical trials are recruiting for Oncology in Lexington, Kentucky. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Lexington
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
DAREON®-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers
97 clinical trials for Oncology
·Clear filters·A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy
A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer
Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Lead-212 PSV359 Therapy for Patients With Solid Tumors
A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)
A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
EXoPERT EMERALD Clinical Study
A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
Cs-131LDR Brachytherapy for Organ-Preserving Irradiation for Recurrent Cervical and Endometrial Cancer
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
Top Research Study Locations in Lexington
Researchers run research studies in Lexington, KY at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Kentucky | Cancer, Cardiovascular Diseases, Heart Failure | 130 |
| University of Kentucky/Markey Cancer Center | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Metastatic Malignant Solid Neoplasm | 79 |
| Baptist Health Lexington | Breast Cancer, Coronary Artery Disease, Anatomic Stage II Breast Cancer AJCC v8 | 38 |
| Saint Joseph Radiation Oncology Resource Center | Prostate Adenocarcinoma, Malignant Solid Neoplasm, Plasma Cell Myeloma | 25 |
| CommonSpirit Saint Joseph Medical Center - East Lexington | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Cancer | 21 |
| University of Kentucky Medical Center | Adenocarcinoma, Pancreatic Ductal, Advanced Solid Tumor, Cachexia | 16 |
| CommonSpirit Saint Joseph Hospital - Lexington | Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Adenocarcinoma of the Colon | 13 |
| Saint Joseph Hospital East | Prostate Adenocarcinoma, Stage IVA Prostate Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | 13 |
| Baptist Health Hamburg | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8 | 11 |
| Saint Joseph Hospital | Prostate Adenocarcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 10 |
| University of Kentucky Markey Cancer Center | Lung Cancer Screening, Advanced Solid Tumor, Bladder Cancer | 10 |
| University of Kentucky Chandler Medical Center | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 8 |
| Kentucky Children's Hospital | Cardiac Arrest, Cardiopulmonary Arrest, Child Externalizing Behavior | 7 |
| Markey Cancer Center | BRAF Gene Mutation, Cancer of Lung, Cancer of the Lung | 7 |
| Psychopharmacology of Addiction Laboratory | Methamphetamine Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder | 5 |
| AMR Clinical - Lexington | Acute Migraine, Migraine, Overweight or Obesity | 4 |
| The Research Group of Lexington LLC | Obesity, Cardiovascular Disease, Heart Failure | 4 |
| University of Kentucky Research Foundation | Ankylosing Spondylitis, Autoimmune Diseases, Birdshot Chorioretinitis | 4 |
| AMR Clinical | Cannabis Withdrawal, Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity | 3 |
| AMR Lexington | Diabetic Peripheral Neuropathic Pain, RSV Infection, Type 2 Diabetes | 3 |
| Clinical Trial Site | Generalized Myasthenia Gravis, Heavy Menstrual Bleeding (HMB), High Cardiovascular Risk | 3 |
| Lexington VA Health Care System | Lung Cancer Screening, Lung Cancer, Pulmonary Nodule, Solitary | 3 |
| Research Facility | Carcinoid, Carcinoid Tumor, GEP-NET | 3 |
| University of Kentucky - Markey Cancer Center | Advanced Liver Cancers, B-Cell Non-Hodgkins Lymphoma, Breast Cancer | 3 |
| University of Kentucky College of Medicine | Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC), Adolescent Congenital Heart Disease, Candidemia | 3 |
Active & Upcoming Studies in Lexington (2026)
Recruiting trials in Lexington grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (177 active studies)
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
- Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma · Phase 2 · National Cancer Institute (NCI)
Neurology & pain (32 active studies)
- Repeated CBD Administration and Cannabis Outcomes · EARLY_Phase 1 · Hannah Harris
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Cardiovascular (31 active studies)
Diabetes & metabolic (23 active studies)
Mental health & behavior (11 active studies)
- Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis · EARLY_Phase 1 · Hannah Harris
- Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD · Phase 4 · Dr. Dean Reeves Clinic
Pediatric (8 active studies)
- MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease · Oelisoa Andriankaja
- Gamification Effects on the 6-Minute Walk Test in Children · David Toupin
HIV / STI (4 active studies)
- AI-Powered Hepatitis C Single-Encounter Test-and-Treat · Phase 4 · Patrick Grace
- The PROTECT (PrEP Optimization Through Telehealth Care and Treatment) Trial · Hilary L Surratt, PhD
Vaccines (2 active studies)
- Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults · Phase 1 · Clover Biopharmaceuticals USA, LLC
- REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19 · Duke University
Common conditions studied in Lexington
- Heart Failure (10 active studies)
- Obesity (9 active studies)
- Acute Myeloid Leukemia (8 active studies)
- Breast Cancer (8 active studies)
- Ovarian Cancer (8 active studies)
- Malignant Solid Neoplasm (7 active studies)
Leading research sponsors in Lexington
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- NRG Oncology
- Children's Oncology Group
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Lexington?
There are approximately 461 recruiting clinical trials in Lexington, Kentucky listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Lexington pay participants?
Most recruiting trials in Lexington compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Lexington?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Lexington?
The most common conditions under active study in Lexington include Heart Failure (10), Obesity (9), Acute Myeloid Leukemia (8), Breast Cancer (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Lexington?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Lexington on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Lexington?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Lexington?
Recruiting research sites in Lexington include University of Kentucky, University of Kentucky/Markey Cancer Center, Baptist Health Lexington, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Lexington right now?
The largest active categories in Lexington are Cancer & tumors (177), Neurology & pain (32), Cardiovascular (31). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.