Solid tumor Clinical Trials in Orlando, FL
As of August 2026, 29 paid clinical trials are recruiting for Solid tumor in Orlando, Florida. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Related specialties in Orlando
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29 clinical trials for Solid tumor
·Clear filters·Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors
Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
A Study of DB-1310 in Advanced/Metastatic Solid Tumors
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors
JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors
A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.
Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK201 in Participants With Advanced Solid Tumors
A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors
A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Project: Every Child for Younger Patients With Cancer
A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study
A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib
A Phase 1 Study of BHV-1530 in Advanced Solid Tumors
A Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Clinical Activity of Mocertatug Rezetecan for Injection in Participants With Advanced Solid Tumors (BEHOLD-1)
A Phase 1/2 Study of BHV-1510 (Previously PBI-410) in Advanced Solid Tumors
Top Research Study Locations in Orlando
Researchers run research studies in Orlando, FL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| AdventHealth Orlando | Heart Failure, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 58 |
| Nemours Children's Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 37 |
| Arnold Palmer Hospital for Children | Neuroblastoma, B Acute Lymphoblastic Leukemia, Osteosarcoma | 36 |
| Orlando Health | Acute Pancreatitis, Endometrial Cancer, Obesity or Overweight | 32 |
| AdventHealth | Prostate Cancer, Acute Pancreatitis, Cervical Cancer | 31 |
| University of Central Florida | Biospecimen Donation, Breast Cancer, HIV | 29 |
| Orlando Health Cancer Institute | Carcinoma, Non-Small-Cell Lung, Metastatic Melanoma, Metastatic Renal Cell Carcinoma | 28 |
| Advent Health | Colorectal Cancer, Ovarian Cancer, Advanced Malignant Neoplasm | 17 |
| Orlando Clinical Research Center | Healthy, Hepatic Impairment, Hepatic Insufficiency | 14 |
| Charter Research | Alzheimer Disease, Amyloid, Healthy Volunteers | 13 |
| Advent Health Orlando | Acute Kidney Injury, Atrial Fibrillation, Brain Tumor | 11 |
| Florida Cancer Specialists | Breast Cancer, Carcinoma, Non-Small-Cell Lung, Gastroesophageal Junction Adenocarcinoma | 10 |
| Sarah Cannon Research Institute at Florida Cancer Specialists | Advanced Solid Tumor, Mesothelioma, Adenocarcinoma of Esophagus | 9 |
| AdventHealth Cancer Institute | Advanced Solid Tumor, Ovarian Cancer, Platinum-resistant Ovarian Cancer | 8 |
| Charter Research - Orlando | Alcohol Use Disorder, Depressive Disorder, Major, Alzheimer Disease | 8 |
| Clinical Neuroscience Solutions, Inc. | Major Depressive Disorder, Atopic Dermatitis, Attention-Deficit/Hyperactivity Disorder | 8 |
| GSK Investigational Site | HIV Infections, Pulmonary Disease, Chronic Obstructive, Gastrointestinal Neoplasms | 7 |
| AdventHealth Translational Research Institute | Type 2 Diabetes, Diabetes Mellitus, Type 1, Endothelial Dysfunction | 7 |
| Nemours Children's Health | Acute Pain, Bronchiolitis, Bronchodilator Agents | 6 |
| Orlando Health Orlando Regional Medical Center | Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, Advanced Renal Cell Carcinoma | 6 |
| CTR Oakwater, LLC | Focal Segmental Glomerulosclerosis, Kidney Disease, Primary Membranous Nephropathy | 5 |
| Central Florida Pulmonary Group | Cystic Fibrosis (CF), Cardiovascular Diseases, Chronic Pseudomonas Aeruginosa Infection | 5 |
| Digestive and Liver Center of Florida | Obesity or Overweight, Ulcerative Colitis, Crohn's Disease | 5 |
| Orlando Health Digestive Health Institute | Acute Cholecystitis, Biliary Obstruction, Chronic Pancreatitis | 5 |
| Orlando Regional Medical Center | Anastomotic Leaks, Chronic Low-back Pain, Chronic Subdural Hematoma | 5 |
Active & Upcoming Studies in Orlando (2026)
Recruiting trials in Orlando grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (189 active studies)
- Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02) · Phase 3 · Bristol-Myers Squibb
- A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma · Phase 3 · Corbus Pharmaceuticals Inc.
Diabetes & metabolic (48 active studies)
- Continued Access to the Endogenex System for Participants in the ReCET Pivotal Study · Endogenex, Inc.
- A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event · Phase 2 · Eli Lilly and Company
Neurology & pain (42 active studies)
- A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery · Phase 3 · AFT Pharmaceuticals, Ltd.
- A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain · Phase 3 · AFT Pharmaceuticals, Ltd.
Cardiovascular (37 active studies)
- A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event · Phase 2 · Eli Lilly and Company
- Dual-Language B-MORE for Hypertension · Florida State University
Mental health & behavior (16 active studies)
- A Study to Evaluate the Efficacy and Safety of AXS-05 for Smoking Cessation in Adults · Phase 3 · Axsome Therapeutics, Inc.
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) · Phase 2 · Tonix Pharmaceuticals, Inc.
HIV / STI (9 active studies)
- Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral Therapy · Phase 3 · Gilead Sciences
- A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed · Phase 3 · ViiV Healthcare
Eye & vision (7 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
Pediatric (6 active studies)
- Measuring Aided Language Development · University of Central Florida
- Role of Body Composition in Large for Gestational Age Infants (LGA) With Oral Feeding Difficulty · Nemours Children's Clinic
Vaccines (1 active study)
- A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) · Phase 3 · Merck Sharp & Dohme LLC
Common conditions studied in Orlando
- Obesity (16 active studies)
- Breast Cancer (14 active studies)
- Ovarian Cancer (13 active studies)
- Crohn's Disease (12 active studies)
- Heart Failure (12 active studies)
- Ulcerative Colitis (12 active studies)
Leading research sponsors in Orlando
- Eli Lilly and Company
- University of Central Florida
- AstraZeneca
- Children's Oncology Group
- Pfizer
Frequently asked questions
How many paid clinical trials are currently recruiting in Orlando?
There are approximately 708 recruiting clinical trials in Orlando, Florida listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orlando pay participants?
Most recruiting trials in Orlando compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orlando?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orlando?
The most common conditions under active study in Orlando include Obesity (16), Breast Cancer (14), Ovarian Cancer (13), Crohn's Disease (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orlando?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orlando on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orlando?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orlando?
Recruiting research sites in Orlando include AdventHealth Orlando, Nemours Children's Hospital, Arnold Palmer Hospital for Children, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orlando right now?
The largest active categories in Orlando are Cancer & tumors (189), Diabetes & metabolic (48), Neurology & pain (42). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.