A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

Conditions

• Atherosclerosis
• Cardiovascular Disease
• Diabetes Mellitus, Type 2
• Hypertension
• Obesity
• Renal Insufficiency, Chronic

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Clazakizumab — DRUG
  Administered SC
• Placebo — DRUG
  Administered SC

Study Details

The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event. Participation in the study will last about 9 months.

Key Dates

First listed

Aug 25, 2026

Start date

Aug 27, 2026

Status verified

Sep 2026

Primary completion

May 31, 2027

Completion

Oct 31, 2027

Study Design

Enrollment

120 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Clazakizumab Dose 1
  Participants will receive clazakizumab subcutaneously (SC)
• Experimental: Clazakizumab Dose 2
  Participants will receive clazakizumab SC
• Experimental: Clazakizumab Dose 3
  Participants will receive clazakizumab SC
• Placebo Comparator: Placebo
  Participants will receive placebo SC

Primary Outcome Measure

Percent Change from Baseline in hsCRP [ Time Frame: Baseline, Week 12 ]

Central Contacts

• Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  317-615-4559
  [email protected]
• Physicians interested in becoming principal investigators please contact
  [email protected]

Locations (30)

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