A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

Part of paid clinical trials in Huntsville, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT07783802
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Clazakizumab — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event. Participation in the study will last about 9 months.

Key Dates

First listed
Aug 25, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
May 31, 2027
Completion
Oct 31, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Clazakizumab Dose 1
    Participants will receive clazakizumab subcutaneously (SC)
  • Experimental: Clazakizumab Dose 2
    Participants will receive clazakizumab SC
  • Experimental: Clazakizumab Dose 3
    Participants will receive clazakizumab SC
  • Placebo Comparator: Placebo
    Participants will receive placebo SC

Primary Outcome Measure

Percent Change from Baseline in hsCRP [ Time Frame: Baseline, Week 12 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (31)

FacilityCityStateZIPSite coordinators
Heart Center Research, LLCHuntsvilleAlabama35801
2565198472
Walter Haught (PRINCIPAL_INVESTIGATOR)
Eclipse Clinical ResearchTucsonArizona85745
5206479926
Eve Shapiro (PRINCIPAL_INVESTIGATOR)
Pima HeartTucsonArizona85741
7176150659
Ajay Tuli (PRINCIPAL_INVESTIGATOR)
Thrive Clinical Research GroupGlendoraCalifornia91740
626-727-7254
Fahed Bitar (PRINCIPAL_INVESTIGATOR)
Omega Research OrlandoAltamonte SpringsFlorida32714
386-668-4202
Kwabena Ayesu (PRINCIPAL_INVESTIGATOR)
American Research InstituteCutler BayFlorida33157
Manuel Garcia Estrada (PRINCIPAL_INVESTIGATOR)
K2 Medical Research - MaitlandMaitlandFlorida32751
407-810-2790
Neel Patel (PRINCIPAL_INVESTIGATOR)
Florida Institute For Clinical Research, LLCOrlandoFlorida32825
407-658-0966
Humberto Cruz (PRINCIPAL_INVESTIGATOR)
North Georgia Clinical ResearchWoodstockGeorgia30189
6784945735
Bram Wieskopf (PRINCIPAL_INVESTIGATOR)
Accellacare - DuPageLombardIllinois60148
Yoko Momoyama (PRINCIPAL_INVESTIGATOR)
Franciscan Physician Network - Indiana Heart PhysiciansIndianapolisIndiana46237
Anthony Bashall (PRINCIPAL_INVESTIGATOR)
K2 Medical Research - FoxboroughFoxboroughMassachusetts02035
Daniel Sacchetti (PRINCIPAL_INVESTIGATOR)
Revival Research Institute, LLCDearbornMichigan48126
Qaiser Shafiq (PRINCIPAL_INVESTIGATOR)
Olive Branch Family Medical CenterOlive BranchMississippi38654-3514
662-893-8474
Randall Huling (PRINCIPAL_INVESTIGATOR)
Excel Clinical Research, LLCLas VegasNevada89109
7026801500
Robby Quintos (PRINCIPAL_INVESTIGATOR)
Palm Research Center TenayaLas VegasNevada89128
7027365161
Samer Nakhle (PRINCIPAL_INVESTIGATOR)
Rochester Clinical Research - BuffaloBuffaloNew York14217
7164158380
Richard Carlson (PRINCIPAL_INVESTIGATOR)
CHEAR Center LLCThe BronxNew York10455
13472701111
David Bernard (PRINCIPAL_INVESTIGATOR)
Altru Health SystemGrand ForksNorth Dakota58201
Puvanalingam Ayyadurai (PRINCIPAL_INVESTIGATOR)
Velocity Clinical Research, Cincinnati, SpringdaleCincinnatiOhio45246
5136718080
Charles Eger (PRINCIPAL_INVESTIGATOR)
Suburban Research AssociatesWest ChesterPennsylvania19380
Omer Abdullah (PRINCIPAL_INVESTIGATOR)
Cardiology Consultants of Philadelphia YardleyYardleyPennsylvania19067
2153217400
Paul Grena (PRINCIPAL_INVESTIGATOR)
Monroe Biomedical Research - CharlestonNorth CharlestonSouth Carolina29406
8037662680
Gregory Feldman (PRINCIPAL_INVESTIGATOR)
Horizon Clinical Research GroupCypressTexas77429
9494910710
Fadi Alameddine (PRINCIPAL_INVESTIGATOR)
Cardiovascular Specialists of WillowbrookHoustonTexas77070
19494910710
Aditya Samal (PRINCIPAL_INVESTIGATOR)
Texas Cardiology Associates of HoustonKingwoodTexas77339
Robert Salazar (PRINCIPAL_INVESTIGATOR)
Revival Research Institute, LLCMcKinneyTexas75071
Asad Karim (PRINCIPAL_INVESTIGATOR)
Texas Institute of Cardiology, PAMcKinneyTexas75071
214-544-7555
Faisal Wahid (PRINCIPAL_INVESTIGATOR)
Ogden Clinic - Canyon ViewOgdenUtah84404
(385) 271-0684
Stephen Bruce (PRINCIPAL_INVESTIGATOR)
Carient Heart & Vascular - ManassasManassasVirginia20109
7033358750
Hamid Taheri (PRINCIPAL_INVESTIGATOR)
Carient Heart and Vascular LLC-RestonRestonVirginia20190
Adeeb Aghdassi (PRINCIPAL_INVESTIGATOR)

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