Oncology Clinical Trials in Orlando, FL
As of September 2026, 143 paid clinical trials are recruiting for Oncology in Orlando, Florida. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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143 clinical trials for Oncology
·Clear filters·Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Caris Biorepository Research Protocol
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Top Research Study Locations in Orlando
Researchers run research studies in Orlando, FL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| AdventHealth Orlando | Heart Failure, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 59 |
| Nemours Children's Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 37 |
| Arnold Palmer Hospital for Children | Neuroblastoma, B Acute Lymphoblastic Leukemia, Osteosarcoma | 36 |
| Orlando Health | Acute Pancreatitis, Endometrial Cancer, Obesity or Overweight | 32 |
| AdventHealth | Prostate Cancer, Acute Pancreatitis, Cervical Cancer | 31 |
| Orlando Health Cancer Institute | Carcinoma, Non-Small-Cell Lung, Metastatic Melanoma, Metastatic Renal Cell Carcinoma | 28 |
| University of Central Florida | Biospecimen Donation, Breast Cancer, HIV | 27 |
| Advent Health | Colorectal Cancer, Ovarian Cancer, Advanced Malignant Neoplasm | 17 |
| Orlando Clinical Research Center | Healthy, Hepatic Impairment, Hepatic Insufficiency | 14 |
| Charter Research | Alzheimer Disease, Amyloid, Healthy Volunteers | 13 |
| Advent Health Orlando | Acute Kidney Injury, Atrial Fibrillation, Brain Tumor | 11 |
| Florida Cancer Specialists | Breast Cancer, Carcinoma, Non-Small-Cell Lung, Gastroesophageal Junction Adenocarcinoma | 10 |
| Sarah Cannon Research Institute at Florida Cancer Specialists | Advanced Solid Tumor, Mesothelioma, Adenocarcinoma of Esophagus | 9 |
| AdventHealth Cancer Institute | Advanced Solid Tumor, Ovarian Cancer, Platinum-resistant Ovarian Cancer | 8 |
| Charter Research - Orlando | Alcohol Use Disorder, Depressive Disorder, Major, Alzheimer Disease | 8 |
| Clinical Neuroscience Solutions, Inc. | Major Depressive Disorder, Atopic Dermatitis, Attention-Deficit/Hyperactivity Disorder | 8 |
| GSK Investigational Site | HIV Infections, Pulmonary Disease, Chronic Obstructive, Gastrointestinal Neoplasms | 7 |
| AdventHealth Translational Research Institute | Type 2 Diabetes, Diabetes Mellitus, Type 1, Endothelial Dysfunction | 7 |
| Nemours Children's Health | Acute Pain, Bronchiolitis, Bronchodilator Agents | 6 |
| Orlando Health Orlando Regional Medical Center | Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, Advanced Renal Cell Carcinoma | 6 |
| CTR Oakwater, LLC | Focal Segmental Glomerulosclerosis, Kidney Disease, Primary Membranous Nephropathy | 5 |
| Central Florida Pulmonary Group | Cystic Fibrosis (CF), Cardiovascular Diseases, Chronic Pseudomonas Aeruginosa Infection | 5 |
| Digestive and Liver Center of Florida | Obesity or Overweight, Ulcerative Colitis, Crohn's Disease | 5 |
| Orlando Health Digestive Health Institute | Acute Cholecystitis, Biliary Obstruction, Chronic Pancreatitis | 5 |
| Orlando Regional Medical Center | Anastomotic Leaks, Chronic Low-back Pain, Chronic Subdural Hematoma | 5 |
Active & Upcoming Studies in Orlando (2026)
Recruiting trials in Orlando grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (188 active studies)
- Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02) · Phase 3 · Bristol-Myers Squibb
- A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma · Phase 3 · Corbus Pharmaceuticals Inc.
Diabetes & metabolic (47 active studies)
- Continued Access to the Endogenex System for Participants in the ReCET Pivotal Study · Endogenex, Inc.
- A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event · Phase 2 · Eli Lilly and Company
Neurology & pain (42 active studies)
- A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery · Phase 3 · AFT Pharmaceuticals, Ltd.
- A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain · Phase 3 · AFT Pharmaceuticals, Ltd.
Cardiovascular (37 active studies)
- A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event · Phase 2 · Eli Lilly and Company
- Dual-Language B-MORE for Hypertension · Florida State University
Mental health & behavior (16 active studies)
- A Study to Evaluate the Efficacy and Safety of AXS-05 for Smoking Cessation in Adults · Phase 3 · Axsome Therapeutics, Inc.
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) · Phase 2 · Tonix Pharmaceuticals, Inc.
HIV / STI (9 active studies)
- Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral Therapy · Phase 3 · Gilead Sciences
- A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed · Phase 3 · ViiV Healthcare
Eye & vision (7 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
Pediatric (6 active studies)
- Measuring Aided Language Development · University of Central Florida
- Role of Body Composition in Large for Gestational Age Infants (LGA) With Oral Feeding Difficulty · Nemours Children's Clinic
Vaccines (1 active study)
- A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) · Phase 3 · Merck Sharp & Dohme LLC
Common conditions studied in Orlando
- Obesity (15 active studies)
- Breast Cancer (14 active studies)
- Ovarian Cancer (13 active studies)
- Crohn's Disease (12 active studies)
- Heart Failure (12 active studies)
- Ulcerative Colitis (12 active studies)
Leading research sponsors in Orlando
- Eli Lilly and Company
- University of Central Florida
- AstraZeneca
- Children's Oncology Group
- Pfizer
Frequently asked questions
How many paid clinical trials are currently recruiting in Orlando?
There are approximately 706 recruiting clinical trials in Orlando, Florida listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orlando pay participants?
Most recruiting trials in Orlando compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orlando?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orlando?
The most common conditions under active study in Orlando include Obesity (15), Breast Cancer (14), Ovarian Cancer (13), Crohn's Disease (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orlando?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orlando on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orlando?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orlando?
Recruiting research sites in Orlando include AdventHealth Orlando, Nemours Children's Hospital, Arnold Palmer Hospital for Children, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orlando right now?
The largest active categories in Orlando are Cancer & tumors (188), Diabetes & metabolic (47), Neurology & pain (42). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.