Paid Clinical Trials in Orlando, FL
As of June 2026, 753 paid clinical trials are recruiting in Orlando, Florida. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Orlando offers studies at sites including AdventHealth Orlando for conditions such as Breast Cancer, Ovarian Cancer, Endometrial Cancer, Advanced Solid Tumor. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Orlando
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·Clear filters·↓ Download CSVAbout research studies in Orlando
Orlando has approximately 753 recruiting research studies across a wide range of therapeutic areas. Florida hosts major research centers including Mayo Clinic Jacksonville, Moffitt Cancer Center, University of Miami Health System, and Nicklaus Children's Hospital, with strong programs in oncology and cardiovascular research.
Top Research Study Locations in Orlando
Researchers run research studies in Orlando, FL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| AdventHealth Orlando | Heart Failure, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 65 |
| Arnold Palmer Hospital for Children | Neuroblastoma, B Acute Lymphoblastic Leukemia, Osteosarcoma | 39 |
| Nemours Children's Hospital | B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm, Acute Myeloid Leukemia | 36 |
| Orlando Health | Acute Pancreatitis, Endometrial Cancer, Obesity or Overweight | 34 |
| Orlando Health Cancer Institute | Carcinoma, Non-Small-Cell Lung, Metastatic Melanoma, Breast Cancer | 33 |
| University of Central Florida | Biospecimen Donation, HIV, Huntington Disease | 33 |
| AdventHealth | Acute Pancreatitis, Colonic Neoplasms, Heart Failure | 27 |
| Advent Health | Colorectal Cancer, Ovarian Cancer, Advanced Malignant Neoplasm | 17 |
| Orlando Clinical Research Center | Healthy, Hepatic Impairment, Hepatic Insufficiency | 15 |
| Advent Health Orlando | Acute Kidney Injury, Aortic Aneurysm, Aortic Dissection | 12 |
| Florida Cancer Specialists | Breast Cancer, Advanced Cancer, Advanced Solid Tumor | 12 |
| AdventHealth Cancer Institute | Advanced Solid Tumor, Ovarian Cancer, Platinum-resistant Ovarian Cancer | 11 |
| Clinical Neuroscience Solutions, Inc. | Major Depressive Disorder, Atopic Dermatitis, Attention-Deficit/Hyperactivity Disorder | 8 |
| Sarah Cannon Research Institute at Florida Cancer Specialists | Advanced Solid Tumor, Mesothelioma, Adenocarcinoma of Esophagus | 8 |
| Charter Research | Major Depressive Disorder, Mild Cognitive Impairment, Alzheimer Disease | 7 |
| Charter Research - Orlando | Alcohol Use Disorder, Alzheimer Disease, Amyloid | 7 |
| Digestive and Liver Center of Florida | Ulcerative Colitis, Crohn's Disease, Obesity or Overweight | 7 |
| AdventHealth Translational Research Institute | Type 2 Diabetes, Hepatic Steatosis, Insulin Resistance | 6 |
| Nemours Children's Health | Acute Pain, Bronchiolitis, Bronchodilator Agents | 6 |
| GSK Investigational Site | HIV Infections, Gastrointestinal Neoplasms, Neoplasms | 5 |
| Central Florida Pulmonary Group | Cystic Fibrosis (CF), Cardiovascular Diseases, Chronic Pseudomonas Aeruginosa Infection | 5 |
| Florida Cancer Specialists - Lake Nona | Breast Cancer, Endometrial Cancer, Head and Neck Squamous Cell Carcinoma | 5 |
| Orlando Regional Medical Center | Acute Kidney Injury, Anastomotic Leaks, Chronic Subdural Hematoma | 5 |
| AdventHealth East Orlando | Grade 2 Meningioma, Intracranial Meningioma, Metastatic Clear Cell Renal Cell Carcinoma | 4 |
| CTR Oakwater, LLC | Kidney Disease, Primary Membranous Nephropathy, Proteinuric Kidney Disease | 4 |
Active & Upcoming Studies in Orlando (2026)
Recruiting trials in Orlando grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (207 active studies)
- First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer · Phase 1, Phase 2 · AstraZeneca
- Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer · Phase 1 · Generate Biomedicines
Neurology & pain (47 active studies)
- Comparing Yoga Nidra, Yoga, and Control Condition on Pain in Individuals With Chronic Low Back Pain · University of Central Florida
- A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy · Phase 4 · Genentech, Inc.
Diabetes & metabolic (38 active studies)
- Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors · Phase 2 · AdventHealth Translational Research Institute
- Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus · Phase 2 · Hanmi Pharmaceutical Company Limited
Cardiovascular (36 active studies)
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
- Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF) · Medtronic Cardiac Ablation Solutions
Mental health & behavior (19 active studies)
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) · Phase 2 · Tonix Pharmaceuticals, Inc.
- A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
HIV / STI (11 active studies)
- REINItiation of Antiretroviral Therapy Using Oral bicTegravir, emtrIcitAbine and Tenofovir alafenamidE · Phase 4 · CAN Community Health
- Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention · Gilead Sciences
Eye & vision (7 active studies)
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
- Phase 2 Study of ADX-038 in Participants With Geographic Atrophy · Phase 2 · ADARx Pharmaceuticals, Inc.
Pediatric (7 active studies)
- Measuring Aided Language Development · University of Central Florida
- Role of Body Composition in Large for Gestational Age Infants (LGA) With Oral Feeding Difficulty · Nemours Children's Clinic
Vaccines (3 active studies)
- Study of VYD2311 for the Prevention of COVID-19 · Phase 3 · Invivyd, Inc.
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Common conditions studied in Orlando
- Breast Cancer (17 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Ovarian Cancer (14 active studies). Ovarian cancer research examines PARP inhibitors, maintenance therapies, and antibody-drug conjugates for recurrent and platinum-resistant disease.
- Endometrial Cancer (13 active studies). Recruiting Endometrial Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Advanced Solid Tumor (12 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Crohn's Disease (12 active studies). Recruiting Crohn's Disease studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Heart Failure (12 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
Leading research sponsors in Orlando
- University of Central Florida
- Eli Lilly and Company
- AstraZeneca
- Children's Oncology Group
- National Cancer Institute (NCI)
Local regulations and guidelines
Clinical trials in Florida are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Florida research must also comply with the Florida Information Protection Act (FIPA) and additional oversight from the Florida Department of Health.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Orlando. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Orlando
Hipa.ai aggregates every recruiting study in Orlando from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Orlando?
There are approximately 753 recruiting clinical trials in Orlando, Florida listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orlando pay participants?
Most recruiting trials in Orlando compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orlando?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orlando?
The most common conditions under active study in Orlando include Breast Cancer (17), Ovarian Cancer (14), Endometrial Cancer (13), Advanced Solid Tumor (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orlando?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orlando on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orlando?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orlando?
Recruiting research sites in Orlando include AdventHealth Orlando, Arnold Palmer Hospital for Children, Nemours Children's Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orlando right now?
The largest active categories in Orlando are Cancer & tumors (207), Neurology & pain (47), Diabetes & metabolic (38). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.