Oncology Clinical Trials in Philadelphia, PA

As of September 2026, 376 paid clinical trials are recruiting for Oncology in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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377 clinical trials for Oncology

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Study of Neoadjuvant Enfortumab Vedotin and Pembrolizumab in Upper Tract Urothelial Cancer

for Urothelial Carcinoma

Sites in Philadelphia +1 more location

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 18+

Code: NCT06356155·Phase 2·Recruiting·Listed Apr 2024

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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

Sites in Philadelphia +9 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting·Listed Mar 2024

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An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

for Ovary Cancer

Drug: Olaparib

Sites in Philadelphia, Pittsburgh +4 more locations

Sponsor: University of Colorado, Denver

Sex: Female·Age: 18 - 100

Code: NCT05887609·Phase 2·Recruiting·Listed Jun 2023

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Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Philadelphia +6 more locations

Sponsor: Joshua Zeidner

Sex: All·Age: 18+

Code: NCT05442216·Phase 2·Recruiting·Listed Jul 2022

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From Screening to Support: A Multi-Method Analysis of HRSN Integration in Cancer Care

for Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07352579·Recruiting·Listed Jan 2026

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CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

for Acute Leukemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 25

Code: NCT03810196·Recruiting·Listed Jan 2019

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A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

Sites in Philadelphia +9 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting·Listed Nov 2023

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Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations

for Head and Neck Cancer

Sites in Philadelphia +4 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18+

Code: NCT06030011·Recruiting·Listed Sep 2023

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Maintenance Combinatorial Myeloid Immunotherapy for Unresectable Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07199764·Phase 2·Recruiting·Listed Sep 2025

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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

Sites in Philadelphia, West Reading +33 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting·Listed May 2017

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Philadelphia +32 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Allergy Delabeling in Antibiotic Stewardship - Intervention

for Beta Lactam Allergy

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07133074·Phase 4·Recruiting·Listed Aug 2025

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

Sites in Philadelphia +8 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting·Listed Mar 2022

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A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

for Prostate Cancer

Sites in Philadelphia +11 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Male·Age: 18+

Code: NCT06457919·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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Y-90 Treatment Response Using Transarterial Radioembolization

for HCC

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07145801·Phase 2·Recruiting·Listed Aug 2025

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Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

for Hematologic Malignancy

Drug: Venetoclax

Sites in Philadelphia +4 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 0 - 38

Code: NCT06131801·Recruiting·Listed Nov 2023

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Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

for Head and Neck Cancer

Sites in Philadelphia +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06837480·Recruiting·Listed Feb 2025

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TERPS Trial for de Novo Oligometastic Prostate Cancer

for Prostate Cancer

Sites in Philadelphia, Pittsburgh +8 more locations

Sponsor: University of Maryland, Baltimore

Sex: Male·Age: 18+

Code: NCT05223803·Phase 2·Recruiting·Listed Feb 2022

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VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for Solid Tumor

Drug: Atezolizumab

Sites in Philadelphia +6 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 6 Months - 30

Code: NCT04796012·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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PopSci CHW4CervixHealth

for Cervical Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 25 - 65·Accepts healthy volunteers

Code: NCT07336134·Recruiting·Listed Jan 2026

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Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

for B-ALL

Sites in Philadelphia +5 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06579469·Recruiting·Listed Aug 2024

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ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

for Diffuse Midline Glioma (DMG)

Sites in Philadelphia +4 more locations

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 2 - 21

Code: NCT04732065·Phase 1·Recruiting·Listed Feb 2021

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[18F]FES PET/.CT in Uterine Cancer

for Uterine Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05916196·Phase 2·Recruiting·Listed Jun 2023

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

Sites in Philadelphia +3 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting·Listed Apr 2020

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Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES

for Lung Cancer

3 locations in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 35 - 89

Code: NCT05968898·Recruiting·Listed Aug 2023

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Philadelphia, Wilkes-Barre +81 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

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Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking

for Lung Carcinoma

1 location in Philadelphia

Sponsor: Ronald Myers

Sex: All·Age: 50 - 77·Accepts healthy volunteers

Code: NCT05679349·Recruiting·Listed Jan 2023

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Epcoritamab-CAR T Cells for Large B-cell Lymphomas

for Lymphoma, Non-Hodgkin

Drug: Epcoritamab

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06458439·Phase 2·Recruiting·Listed Jun 2024

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ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04523857·Phase 2·Recruiting·Listed Aug 2020

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Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

for Lung Cancer

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05800587·Phase 2·Recruiting·Listed Apr 2023

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Philadelphia +14 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Philadelphia, Hershey +74 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

for Prostate Carcinoma

Sites in Philadelphia +6 more locations

Sponsor: University of Washington

Sex: Male·Age: 40+·Accepts healthy volunteers

Code: NCT04472338·Recruiting·Listed Jul 2020

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Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

for Urothelial Carcinoma Bladder

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06586255·Phase 1·Recruiting·Listed Sep 2024

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SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia With FLT3/ITD Mutation

Sites in Philadelphia +3 more locations

Sponsor: Uma Borate

Sex: All·Age: 18+

Code: NCT06222580·Phase 1·Recruiting·Listed Jan 2024

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Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

for Oropharyngeal Squamous Cell Carcinoma (OPSCCA)

1 location in Philadelphia

Sponsor: Ryan Carey

Sex: All·Age: 18+

Code: NCT06747390·Phase 1·Recruiting·Listed Dec 2024

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Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy

for Bladder Cancer

2 locations in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18 - 85

Code: NCT07234968·Recruiting·Listed Nov 2025

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CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer

for Endometrial Cancer

2 locations in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT07278986·EARLY_Phase 1·Recruiting·Listed Dec 2025

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

Sites in Philadelphia +6 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting·Listed Apr 2021

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A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

for Hematopoietic and Lymphoid Cell Neoplasm

Sites in Philadelphia +27 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 2 - 18

Code: NCT05711667·Phase 3·Recruiting·Listed Feb 2023

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Conditions in Oncology (Philadelphia, PA)

Solid tumor· 57 Breast cancer· 44 Non-small cell lung cancer (NSCLC)· 36 Cancer (any)· 36 Colorectal cancer· 27 Ovarian cancer· 26 Prostate cancer· 24 Acute myeloid leukemia (AML)· 24 Pancreatic cancer· 21 Endometrial cancer· 18 Non-Hodgkin lymphoma· 18 Head and neck cancer· 16 Gastric cancer· 15 Bladder cancer· 14 Hematologic malignancy· 13 Glioma· 12 Multiple myeloma· 12 Diffuse large B-cell lymphoma (DLBCL)· 12 Esophageal cancer· 10 Myelodysplastic syndromes (MDS)· 10 Lung cancer· 9 Liver cancer· 9 Metastatic prostate cancer· 9 Kidney cancer· 9 Leukemia (other)· 9 Fallopian tube cancer· 8 Melanoma· 8 Neuroblastoma· 8 Pediatric cancer· 8 Cervical cancer· 7 Chronic lymphocytic leukemia (CLL)· 7 Neuroendocrine tumors· 7 Metastatic breast cancer· 6 Triple-negative breast cancer· 6 Biliary tract cancer· 6 Glioblastoma· 6 Hodgkin lymphoma· 6 Ewing sarcoma· 6 Osteosarcoma· 5 Gastroesophageal junction cancer· 4 Acute lymphoblastic leukemia· 4 Myelofibrosis· 4 Small lymphocytic lymphoma· 4 HER2-positive breast cancer· 3 HER2-negative breast cancer· 3 Small cell lung cancer· 3 Myeloproliferative neoplasm· 3 Follicular lymphoma· 3 Burkitt lymphoma· 3 Thyroid cancer· 3 Rhabdomyosarcoma· 3 Gastrointestinal cancer· 2 Uterine cancer· 2 Brain cancer· 2 Mantle cell lymphoma· 2 Marginal zone lymphoma· 2 Soft tissue sarcoma· 2 Metastatic colorectal cancer· 1 Chronic myelomonocytic leukemia· 1 Skin cancer· 1 Sarcoma· 1 Mesothelioma· 1