MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Rolla, Jefferson City +2341 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Paid Clinical Trials in Rolla, MO
As of July 2026, 43 paid clinical trials are recruiting in Rolla, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Rolla offers studies at sites including Mercy Clinic-Rolla-Cancer and Hematology for conditions such as Malignant Solid Neoplasm, Anatomic Stage IV Breast Cancer AJCC v8, Chronic Lymphocytic Leukemia, Hematopoietic and Lymphatic System Neoplasm. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Rolla
Trials by drug in Rolla
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43 clinical trials
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
for Ampulla of Vater Carcinoma
Sites in Rolla, Sullivan +330 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07283939·Recruiting·Listed Dec 2025
CARE Tool Study Aim 3
for Gynecologic Cancer
Sites in Rolla, St Louis +1 more location
Sponsor: Washington University School of Medicine
Sex: All·Age: 18+
Code: NCT07296887·Recruiting·Listed Dec 2025
Family Communications After Genetic Testing
for Colon Adenocarcinoma
Sites in Rolla, Sullivan +273 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07143487·Recruiting·Listed Aug 2025
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Rolla, Sullivan +1103 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
for Miscellaneous Neoplasm, Nos
Sites in Rolla, Sullivan +277 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07091617·Recruiting·Listed Jul 2025
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
for Chronic Lymphocytic Leukemia
Sites in Rolla, Sullivan +296 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
for Stage III Colon Cancer
Sites in Rolla, Sullivan +920 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
for Head and Neck Squamous Cell Carcinoma
Sites in Rolla, Sullivan +464 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
for Intracranial Meningioma
Sites in Rolla, Sullivan +454 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
for Locally Advanced Cervical Adenocarcinoma
Sites in Rolla, St Louis +294 more locations
Sponsor: National Cancer Institute (NCI)
Sex: Female·Age: 18+
Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
for Advanced Esophageal Adenocarcinoma
Drug: Nivolumab
Sites in Rolla, Sullivan +641 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
for Acute Lymphoblastic Leukemia
Sites in Rolla, Sullivan +629 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 40 - 75·Accepts healthy volunteers
Code: NCT05334069·Recruiting·Listed Apr 2022
Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects
for Malignancy
Sites in Rolla, Sullivan +403 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: All ages
Code: NCT04242095·Recruiting·Listed Jan 2020
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
for Plasma Cell Myeloma
Sites in Rolla, Sullivan +226 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT04566328·Phase 3·Recruiting·Listed Sep 2020
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
for Adenocarcinoma of the Colon
Sites in Rolla, Washington +363 more locations
Sponsor: NRG Oncology
Sex: All·Age: 45 - 70
Code: NCT05080673·Recruiting·Listed Oct 2021
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
for Smoldering Plasma Cell Myeloma
Drug: Daratumumab
Sites in Rolla, Sullivan +486 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT03937635·Phase 3·Recruiting·Listed May 2019
Mobile Health for Adherence in Breast Cancer Patients
for Anatomic Stage IV Breast Cancer AJCC v8
Sites in Rolla, Washington +457 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT06112613·Recruiting·Listed Nov 2023
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
for Hodgkin Lymphoma
Sites in Rolla, Sullivan +403 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT06002828·Recruiting·Listed Aug 2023
Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer
for Resectable Lung Non-Small Cell Carcinoma
Sites in Rolla, Sullivan +306 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06632327·Phase 3·Recruiting·Listed Oct 2024
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
for Advanced Lung Non-Small Cell Carcinoma
Drug: Osimertinib
Sites in Rolla, Sullivan +217 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT03191149·Phase 2·Recruiting·Listed Jun 2017
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
for Plasma Cell Myeloma
Sites in Rolla, Sullivan +387 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: All ages
Code: NCT05561387·Phase 3·Recruiting·Listed Sep 2022
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)
for Malignant Solid Neoplasm
Sites in Rolla, Sullivan +363 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: All ages·Accepts healthy volunteers
Code: NCT06295367·Recruiting·Listed Mar 2024
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
for Biochemically Recurrent Prostate Carcinoma
Drug: Apalutamide
Sites in Rolla, Sullivan +276 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: Male·Age: 18+
Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program
for Cigarette Smoking-Related Carcinoma
Sites in Rolla, Sullivan +204 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05008848·Phase 3·Recruiting·Listed Aug 2021
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
for Hematopoietic and Lymphatic System Neoplasm
Sites in Rolla, Washington +190 more locations
Sponsor: Children's Oncology Group
Sex: Female·Age: Up to 39
Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
for Refractory Differentiated Thyroid Gland Carcinoma
Sites in Rolla, Washington +286 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT06475989·Phase 3·Recruiting·Listed Jun 2024
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
for Prostate Adenocarcinoma
Sites in Rolla, Creve Coeur +397 more locations
Sponsor: NRG Oncology
Sex: Male·Age: 18+
Code: NCT05946213·Phase 3·Recruiting·Listed Jul 2023
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
for Malignant Solid Neoplasm
Sites in Rolla, Sullivan +586 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT04871542·Recruiting·Listed May 2021
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
for Muscle Invasive Bladder Urothelial Carcinoma
Sites in Rolla, Sullivan +206 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT07097142·Phase 3·Recruiting·Listed Jul 2025
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
for Stage I Breast Cancer
Sites in Rolla, Sullivan +705 more locations
Sponsor: NRG Oncology
Sex: All·Age: 50 - 70
Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
for Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7
Sites in Rolla, Ballwin +117 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT03493425·Phase 2·Recruiting·Listed Apr 2018
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
for Anatomic Stage IV Breast Cancer AJCC v8
Sites in Rolla, Sullivan +584 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT03723928·Recruiting·Listed Oct 2018
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
for Fallopian Tube Endometrioid Adenocarcinoma
Drug: Bevacizumab
Sites in Rolla, Sullivan +643 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
for Colorectal Cancer Stage II
Sites in Rolla, Sullivan +373 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07018869·Phase 3·Recruiting·Listed Jun 2025
Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
for Non Small Cell Lung Cancer
Drug: Osimertinib
Sites in Rolla, St Louis +144 more locations
Sponsor: PrECOG, LLC.
Sex: All·Age: 18+
Code: NCT06538038·Recruiting·Listed Aug 2024
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
for Metastatic Malignant Neoplasm in the Liver
Sites in Rolla, Washington +378 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
for Anatomic Stage I Breast Cancer AJCC v8
Sites in Rolla, Sullivan +913 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
for Acral Lentiginous Melanoma
Drug: Ipilimumab
Sites in Rolla, Sullivan +301 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT04511013·Phase 2·Recruiting·Listed Aug 2020
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial
for Metastatic Clear Cell Renal Cell Carcinoma
Sites in Rolla, Sullivan +338 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020
Top Research Study Locations in Rolla
Researchers run research studies in Rolla, MO at 6 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mercy Clinic-Rolla-Cancer and Hematology | Malignant Solid Neoplasm, Anatomic Stage IV Breast Cancer AJCC v8, Plasma Cell Myeloma | 36 |
| Phelps Health Delbert Day Cancer Institute | Malignant Solid Neoplasm, Chronic Lymphocytic Leukemia, Prostate Adenocarcinoma | 32 |
| Delbert Day Cancer Institute at PCRMC | Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8, Castration Levels of Testosterone | 8 |
| Delbert Day Cancer Institute at Phelps Health | Colorectal Cancer, Gynecologic Cancer, Lung Cancer | 1 |
| Mercy Clinic Cancer and Hematology | Epidermal Growth Factor Receptor Gene Mutation, Non Small Cell Lung Cancer, Stage III Lung Cancer | 1 |
| Phelps County Regional Medical Center | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Rolla (2026)
Recruiting trials in Rolla grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (33 active studies)
- CARE Tool Study Aim 3 · Washington University School of Medicine
- Family Communications After Genetic Testing · Alliance for Clinical Trials in Oncology
Mental health & behavior (1 active study)
- Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program · Phase 3 · Alliance for Clinical Trials in Oncology
Common conditions studied in Rolla
- Malignant Solid Neoplasm (5 active studies)
- Anatomic Stage IV Breast Cancer AJCC v8 (2 active studies)
- Chronic Lymphocytic Leukemia (2 active studies)
- Hematopoietic and Lymphatic System Neoplasm (2 active studies)
- Plasma Cell Myeloma (2 active studies)
- Prostate Adenocarcinoma (2 active studies)
Leading research sponsors in Rolla
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- ECOG-ACRIN Cancer Research Group
- NRG Oncology
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Rolla?
There are approximately 43 recruiting clinical trials in Rolla, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Rolla pay participants?
Most recruiting trials in Rolla compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Rolla?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Rolla?
The most common conditions under active study in Rolla include Malignant Solid Neoplasm (5), Anatomic Stage IV Breast Cancer AJCC v8 (2), Chronic Lymphocytic Leukemia (2), Hematopoietic and Lymphatic System Neoplasm (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Rolla?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rolla on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Rolla?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Rolla?
Recruiting research sites in Rolla include Mercy Clinic-Rolla-Cancer and Hematology, Phelps Health Delbert Day Cancer Institute, Delbert Day Cancer Institute at PCRMC, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Rolla right now?
The largest active categories in Rolla are Cancer & tumors (33), Mental health & behavior (1). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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