Oncology Clinical Trials in Silver Spring, MD
As of August 2026, 22 paid clinical trials are recruiting for Oncology in Silver Spring, Maryland. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Silver Spring
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
23 clinical trials for Oncology
·Clear filters·Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
Study of ORIC-944 in Patients With Metastatic Prostate Cancer
Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
BP1001-A in Patients With Advanced or Recurrent Solid Tumors
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
Top Research Study Locations in Silver Spring
Researchers run research studies in Silver Spring, MD at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Holy Cross Hospital | Carcinoma, Ovarian Epithelial, Endometrial Cancer, Endometrioid Ovarian Cancer | 8 |
| Maryland Oncology Hematology, P.A. | Gastroesophageal Junction Cancer, Advanced Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung | 5 |
| Adventist Healthcare White Oak Medical Center | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, Acute Myocardial Infarction | 3 |
| Maryland Oncology Hematology | Cancer, Chronic Lymphocytic Leukemia (CLL), Metastatic Prostate Cancer | 3 |
| Maryland Oncology Hematology - Silver Spring | Untreated, Unresectable, or Metastatic Colorectal Cancer, Chronic Lymphocytic Leukemia, Multiple Myeloma | 3 |
| Food and Drug Administration | Age-Related Macular Degeneration, Cone Dystrophy, Cone Rod Dystrophy | 2 |
| Jadestone Clinical Research | COVID-19 Infection, COVID-19 SARS-CoV-2 Infection | 2 |
| Maryland Oncology Hematology P A | Carcinoma, Non-Small-Cell Lung, Early Breast Cancer | 2 |
| TSC Alliance | Adult Caregivers of Individuals With TSC, Lymphangioleiomyomatosis, Tuberous Sclerosis | 2 |
| ACCOMPLISH-1 Research Site | Chronic Weight Management, Obesity, Overweight | 1 |
| ACCOMPLISH-2 Research Site | Chronic Weight Management, Obesity, Overweight | 1 |
| Children's National Medical Center, Children's Research Institute | Caregiver Burden, Tracheostomy | 1 |
| Childrens National Hospital | Palliative Care Education | 1 |
| Direct Biologics Investigational Site | ARDS, Acute Respiratory Distress Syndrome | 1 |
| Food and Drug Administration (FDA) | Glaucoma | 1 |
| Holy Cross Hospital - Silver Spring | Breast Cancer | 1 |
| Jadestone Clinical Research, LLC | Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | 1 |
| Javara | Focal Epilepsy | 1 |
| Javara Inc./Privia Medical Group - Silver Spring, MD - Columbia Pike | Proteinuric Kidney Disease | 1 |
| Local Institution - 0523 | Non-Small Cell Lung Cancer | 1 |
| Maryland Eye Consultants and Surgeons | Ocular Hypertension, Suspect Glaucoma | 1 |
| Maryland Oncology Hematology P.A. | Breast Cancer | 1 |
| Maryland Oncology Hematology, PA | Breast Cancer | 1 |
| Massive Bio SYNERGY-AI site | BRCA Gene Rearrangement, Bladder Cancer, Breast Cancer | 1 |
| Medical Center Orthotics and Prosthetics - Silver Spring | Upper Limb Amputation Above Elbow, Upper Limb Amputation Below Elbow | 1 |
Active & Upcoming Studies in Silver Spring (2026)
Recruiting trials in Silver Spring grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (29 active studies)
- Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02) · Phase 3 · Bristol-Myers Squibb
- Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer · Phase 2, Phase 3 · Pfizer
Eye & vision (4 active studies)
- Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects · Phase 4 · University of Maryland, Baltimore
- Retinal Blood Flow and Autoregulation · Phase 4 · University of Maryland, Baltimore
Vaccines (3 active studies)
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised · Phase 3 · Pfizer
- A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease · Phase 3 · Pfizer
Diabetes & metabolic (3 active studies)
- A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Cardiovascular (3 active studies)
- Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects · Phase 4 · University of Maryland, Baltimore
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention · Phase 4 · Duke University
Neurology & pain (2 active studies)
- Long-term Safety and Tolerability of BHV-7000 · Phase 2 · Biohaven Therapeutics Ltd.
- Acoustic Stimulation During Restricted Sleep After Sleep Deprivation · Walter Reed Army Institute of Research (WRAIR)
Common conditions studied in Silver Spring
- Endometrial Cancer (5 active studies)
- Breast Cancer (4 active studies)
- Acute Stress Reaction (2 active studies)
- Cancer (2 active studies)
- Carcinoma, Non-Small-Cell Lung (2 active studies)
- Chronic Weight Management (2 active studies)
Leading research sponsors in Silver Spring
- AstraZeneca
- Pfizer
- AbbVie
- Merck Sharp & Dohme LLC
- Walter Reed Army Institute of Research (WRAIR)
Frequently asked questions
How many paid clinical trials are currently recruiting in Silver Spring?
There are approximately 58 recruiting clinical trials in Silver Spring, Maryland listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Silver Spring pay participants?
Most recruiting trials in Silver Spring compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Silver Spring?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Silver Spring?
The most common conditions under active study in Silver Spring include Endometrial Cancer (5), Breast Cancer (4), Acute Stress Reaction (2), Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Silver Spring?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Silver Spring on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Silver Spring?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Silver Spring?
Recruiting research sites in Silver Spring include Holy Cross Hospital, Maryland Oncology Hematology, P.A., Adventist Healthcare White Oak Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Silver Spring right now?
The largest active categories in Silver Spring are Cancer & tumors (29), Eye & vision (4), Vaccines (3). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.