Paid Clinical Trials in Silver Spring, MD
As of July 2026, 58 paid clinical trials are recruiting in Silver Spring, Maryland. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Silver Spring offers studies at sites including Holy Cross Hospital for conditions such as Breast Cancer, Endometrial Cancer, Acute Stress Reaction, Carcinoma, Non-Small-Cell Lung. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Silver Spring
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Researchers run research studies in Silver Spring, MD at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Holy Cross Hospital | Carcinoma, Ovarian Epithelial, Endometrial Cancer, Endometrioid Ovarian Cancer | 8 |
| Maryland Oncology Hematology, P.A. | Gastroesophageal Junction Cancer, Advanced Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung | 5 |
| Adventist Healthcare White Oak Medical Center | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, Acute Myocardial Infarction | 3 |
| Maryland Oncology Hematology | Cancer, Chronic Lymphocytic Leukemia (CLL), Metastatic Prostate Cancer | 3 |
| Maryland Oncology Hematology - Silver Spring | Untreated, Unresectable, or Metastatic Colorectal Cancer, Chronic Lymphocytic Leukemia, Multiple Myeloma | 3 |
| Food and Drug Administration | Age-Related Macular Degeneration, Cone Dystrophy, Cone Rod Dystrophy | 2 |
| Jadestone Clinical Research | COVID-19 Infection, COVID-19 SARS-CoV-2 Infection | 2 |
| Maryland Oncology Hematology P A | Carcinoma, Non-Small-Cell Lung, Early Breast Cancer | 2 |
| TSC Alliance | Adult Caregivers of Individuals With TSC, Lymphangioleiomyomatosis, Tuberous Sclerosis | 2 |
| Holy Cross Hospital - Silver Spring | Breast Cancer, Folate Receptor-Alpha Positive, Recurrent Ovarian Cancer | 2 |
| ACCOMPLISH-1 Research Site | Chronic Weight Management, Obesity, Overweight | 1 |
| ACCOMPLISH-2 Research Site | Chronic Weight Management, Obesity, Overweight | 1 |
| Children's National Medical Center, Children's Research Institute | Caregiver Burden, Tracheostomy | 1 |
| Childrens National Hospital | Palliative Care Education | 1 |
| Direct Biologics Investigational Site | ARDS, Acute Respiratory Distress Syndrome | 1 |
| Food and Drug Administration (FDA) | Glaucoma | 1 |
| Jadestone Clinical Research, LLC | Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | 1 |
| Javara | Focal Epilepsy | 1 |
| Javara Inc./Privia Medical Group - Silver Spring, MD - Columbia Pike | Proteinuric Kidney Disease | 1 |
| Local Institution - 0523 | Non-Small Cell Lung Cancer | 1 |
| Maryland Eye Consultants and Surgeons | Ocular Hypertension, Suspect Glaucoma | 1 |
| Maryland Oncology Hematology P.A. | Breast Cancer | 1 |
| Maryland Oncology Hematology, PA | Breast Cancer | 1 |
| Massive Bio SYNERGY-AI site | BRCA Gene Rearrangement, Bladder Cancer, Breast Cancer | 1 |
| Medical Center Orthotics and Prosthetics - Silver Spring | Upper Limb Amputation Above Elbow, Upper Limb Amputation Below Elbow | 1 |
Active & Upcoming Studies in Silver Spring (2026)
Recruiting trials in Silver Spring grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (29 active studies)
- Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02) · Phase 3 · Bristol-Myers Squibb
- Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer · Phase 2, Phase 3 · Pfizer
Eye & vision (4 active studies)
- Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects · Phase 4 · University of Maryland, Baltimore
- Retinal Blood Flow and Autoregulation · Phase 4 · University of Maryland, Baltimore
Vaccines (3 active studies)
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised · Phase 3 · Pfizer
- A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease · Phase 3 · Pfizer
Diabetes & metabolic (3 active studies)
- Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Cardiovascular (3 active studies)
- Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects · Phase 4 · University of Maryland, Baltimore
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention · Phase 4 · Duke University
Neurology & pain (2 active studies)
- Long-term Safety and Tolerability of BHV-7000 · Phase 2 · Biohaven Therapeutics Ltd.
- Acoustic Stimulation During Restricted Sleep After Sleep Deprivation · Walter Reed Army Institute of Research (WRAIR)
Common conditions studied in Silver Spring
- Breast Cancer (4 active studies)
- Endometrial Cancer (4 active studies)
- Acute Stress Reaction (2 active studies)
- Cancer (2 active studies)
- Carcinoma, Non-Small-Cell Lung (2 active studies)
- Chronic Weight Management (2 active studies)
Leading research sponsors in Silver Spring
- Pfizer
- AstraZeneca
- AbbVie
- Merck Sharp & Dohme LLC
- Walter Reed Army Institute of Research (WRAIR)
Frequently asked questions
How many paid clinical trials are currently recruiting in Silver Spring?
There are approximately 58 recruiting clinical trials in Silver Spring, Maryland listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Silver Spring pay participants?
Most recruiting trials in Silver Spring compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Silver Spring?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Silver Spring?
The most common conditions under active study in Silver Spring include Breast Cancer (4), Endometrial Cancer (4), Acute Stress Reaction (2), Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Silver Spring?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Silver Spring on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Silver Spring?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Silver Spring?
Recruiting research sites in Silver Spring include Holy Cross Hospital, Maryland Oncology Hematology, P.A., Adventist Healthcare White Oak Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Silver Spring right now?
The largest active categories in Silver Spring are Cancer & tumors (29), Eye & vision (4), Vaccines (3). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.