Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in Sioux Falls +47 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
Clinical Trials at Sanford Health
As of August 2026, 14 paid clinical trials are recruiting at Sanford Health, located at 3401 W 49TH ST, SUITE 2, SIOUX FALLS, SD 57106-2322, phone (605) 328-1626 in Sioux Falls, South Dakota. Active studies at this site cover conditions such as Breast Cancer, Ovarian Cancer and Endometrial Cancer. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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14 clinical trials at Sanford Health
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A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma
for Endometrial Adenocarcinoma
Sites in Sioux Falls +41 more locations
Sponsor: Acrivon Therapeutics
Sex: Female·Age: 18+
Code: NCT05548296·Phase 2·Recruiting·Listed Sep 2022
BOOM-IBD2 Pivotal Clinical Trial
for Ulcerative Colitis
Sites in Sioux Falls +16 more locations
Sponsor: Boomerang Medical
Sex: All·Age: 18 - 85
Code: NCT06571669·Recruiting·Listed Aug 2024
Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)
for Overactive Bladder (OAB)
Sites in Sioux Falls +14 more locations
Sponsor: FemPulse Corporation
Sex: Female·Age: 21+
Code: NCT07195656·Recruiting·Listed Sep 2025
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
for Breast Cancer
Sites in Sioux Falls +21 more locations
Sponsor: Celcuity Inc
Sex: All·Age: 18+
Code: NCT06757634·Phase 3·Recruiting·Listed Jan 2025
Ambulatory Long Length URodynamics Evaluation
for Urology
Sites in Sioux Falls +6 more locations
Sponsor: Bright Uro
Sex: All·Age: 22+
Code: NCT07425015·Recruiting·Listed Feb 2026
Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer
for Epithelial Ovarian Cancer
Drug: IMNN-001
Sites in Sioux Falls +7 more locations
Sponsor: Imunon
Sex: Female·Age: 18+
Code: NCT06915025·Phase 3·Recruiting·Listed Apr 2025
VIrtual STudy in Achondroplasia for the US (VISTA)
for Achondroplasia
Sites in Sioux Falls +7 more locations
Sponsor: BioMarin Pharmaceutical
Sex: All·Age: 0 Months - 18
Code: NCT06168201·Recruiting·Listed Dec 2023
Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
for Open tíbia Fracture
Sites in Sioux Falls +26 more locations
Sponsor: University of Maryland, Baltimore
Sex: All·Age: 18+
Code: NCT05615844·Phase 3·Recruiting·Listed Nov 2022
Connect for Cancer Prevention Study (Connect)
for Cancer
Sites in Sioux Falls +8 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 30 - 70·Accepts healthy volunteers
Code: NCT04609072·Recruiting·Listed Oct 2020
Midwest Birth Outcomes and Indigenous American Pregnancy
for Pregnancy
Sites in Sioux Falls +1 more location
Sponsor: Sanford Health
Sex: Female·Age: 18+·Accepts healthy volunteers
Code: NCT06008561·Recruiting·Listed Aug 2023
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
for Rare Disorders
1 location in Sioux Falls
Sponsor: Sanford Health
Sex: All·Age: All ages
Code: NCT01793168·Recruiting·Listed Feb 2013
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
for Heart Failure
Sites in Sioux Falls +11 more locations
Sponsor: University of Kansas Medical Center
Sex: All·Age: 18 - 100
Code: NCT06425848·Recruiting·Listed May 2024
Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Carotid Stenting (SKYWARD Trans-Carotid IDE [Investigational Device Exemption] Study)
for Carotid Artery Calcification
Sites in Sioux Falls +24 more locations
Sponsor: Shockwave Medical, Inc.
Sex: All·Age: 18+
Code: NCT07062471·Recruiting·Listed Jul 2025
Common conditions studied in Sioux Falls
- Breast Cancer (10 active studies)
- Ovarian Cancer (9 active studies)
- Endometrial Cancer (8 active studies)
- Stage IV Lung Cancer AJCC v8 (7 active studies)
- Heart Failure (6 active studies)
- Malignant Solid Neoplasm (5 active studies)
Leading research sponsors in Sioux Falls
- National Cancer Institute (NCI)
- Merck Sharp & Dohme LLC
- Children's Oncology Group
- Alliance for Clinical Trials in Oncology
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Sioux Falls?
There are approximately 247 recruiting clinical trials in Sioux Falls, South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Sioux Falls pay participants?
Most recruiting trials in Sioux Falls compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Sioux Falls?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Sioux Falls?
The most common conditions under active study in Sioux Falls include Breast Cancer (10), Ovarian Cancer (9), Endometrial Cancer (8), Stage IV Lung Cancer AJCC v8 (7), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Sioux Falls?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Sioux Falls on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Sioux Falls?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Sioux Falls?
Recruiting research sites in Sioux Falls include Sanford USD Medical Center - Sioux Falls, Sanford Cancer Center Oncology Clinic, Avera Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Sioux Falls right now?
The largest active categories in Sioux Falls are Cancer & tumors (153), Cardiovascular (12), Eye & vision (8). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Sanford Health?
Sanford Health is located at 3401 W 49TH ST, SUITE 2, SIOUX FALLS, SD 57106-2322. Use the Google Maps link in the intro above to get directions.
How do I contact Sanford Health?
You can reach Sanford Health by phone at (605) 328-1626. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.